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• W2103756995 abstract "L-DOPA remains the mainstay of therapy for Parkinson’s disease (PD). However, the side-effects associated with its chronic use have fuelled the search for novel strategies as an alternative to simply supplementing dopamine deficiency. In reviewing the advances made over the last five years, focus has been given to dopamine agonists, as well as to new MAO inhibitors that appear more effective than the currently used compound, selegiline. A number of new molecules acting at sites of the neuronal circuit distal from lesioned dopaminergic neurones have also been considered, including NMDA antagonists, adenosine antagonists and anticholinergic agents, this latter group representing the pioneering approach to PD treatment. In addition, new concepts of ‘neuroprotection’ have led to the exploitation of various agents, especially anti-oxidants, directed toward slowing or halting disease progression. An entirely new perspective has been provided by methods that apply the techniques of molecular biology to PD therap..." @default.
• W2103756995 created "2016-06-24" @default.
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• W2103756995 date "1998-10-01" @default.
• W2103756995 modified "2023-09-25" @default.
• W2103756995 title "New directions in Parkinson’s research and treatment" @default.
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• W2103756995 doi "https://doi.org/10.1517/13543776.8.10.1251" @default.
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