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• W2103759718 abstract "The efficacy of Formalin-inactivated Venezuelan equine encephalitis (VEE) vaccine has been reported to be low for man. Although a live VEE vaccine has been shown to be highly effective for the protection of laboratory workers, local and systemic reactions have occurred in approximately 20% of inoculated individuals. Therefore, studies were initiated in an attempt to produce an inactivated vaccine of high potency with low toxicity. Inactivated VEE vaccines were prepared by exposing virus suspensions to 8 � 10 6 or 10 � 10 6 r of gamma radiation. Irradiated VEE vaccines prepared from virus suspensions produced in Maitland-type chick embryo (MTCE) cell cultures and in monolayer cultures of human diploid strain WI-38 cells were highly immunogenic for mice and guinea pigs. Guinea pigs vaccinated with a series of three inoculations of vaccine (MTCE) survived challenge with at least 10 8�4 mouse intracerebral 50% lethal doses of VEE virus. Irradiated vaccines induced high levels of serum-neutralizing and hemagglutinin-inhibiting antibodies in guinea pigs and rabbits. These findings suggest that ionizing radiation may be effective in the preparation of an inactivated VEE vaccine." @default.
• W2103759718 created "2016-06-24" @default.
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• W2103759718 date "1970-05-01" @default.
• W2103759718 modified "2023-10-16" @default.
• W2103759718 title "Gamma-Irradiated Venezuelan Equine Encephalitis Vaccines" @default.
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• W2103759718 doi "https://doi.org/10.1128/am.19.5.763-767.1970" @default.
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