Matches in SemOpenAlex for { <https://semopenalex.org/work/W2103764114> ?p ?o ?g. }
- W2103764114 abstract "This review focuses on the mechanisms of stress response in the synovial tissue of rheumatoid arthritis. The major stress factors, such as heat stress, shear stress, proinflammatory cytokines and oxidative stress, are discussed and reviewed, focusing on their potential to induce a stress response in the synovial tissue. Several pathways of stress signalling molecules are found to be activated in the synovial membrane of rheumatoid arthritis; of these the most important examples are heat shock proteins, mitogen-activated protein kinases, stress-activated protein kinases and molecules involved in the oxidative stress pathways. The expression of these pathways in vitro and in vivo as well as the consequences of stress signalling in the rheumatoid synovium are discussed. Stress signalling is part of a cellular response to potentially harmful stimuli and thus is essentially involved in the process of synovitis. Stress signalling pathways are therefore new and promising targets of future anti-rheumatic therapies." @default.
- W2103764114 created "2016-06-24" @default.
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- W2103764114 date "2001-01-01" @default.
- W2103764114 modified "2023-10-04" @default.
- W2103764114 title "The stressed synovium" @default.
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- W2103764114 doi "https://doi.org/10.1186/ar144" @default.
- W2103764114 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/128883" @default.
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