FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2103764243> ?p ?o ?g. }

• W2103764243 endingPage "679" @default.
• W2103764243 startingPage "674" @default.
• W2103764243 abstract "Objectives Caffeic acid phenethyl ester (CAPE) has been subjected to considerable investigations that have revealed its antioxidant and anti-inflammatory activities in different conditions. But there is not a previous investigation about its effect on cholestatic liver injury. The aim of this study was to investigate the effect of CAPE in rat liver against cholestatic liver injury induced by bile duct ligation. Methods Swiss-albino rats were recruited in the study as follows; Group 1 rats subjected to simple laparotomy known as the sham group; Group 2 rats subjected to bile duct ligation (BDL); Group 3 bile duct ligated rats treated with CAPE. The third group received CAPE (10 μmol/kg) intraperitoneally daily throughout 14 d. Results Data showed a decrease in γ glutamyl transferase (GGT), aspartate aminotransferase (AST), and alanine aminotransferase levels (ALT) of the CAPE treated rats, compared with BDL group (P < 0.001, P < 0.01, and P < 0.02, respectively). In the CAPE treated rats, tissue levels of malondialdehyde (MDA) and myeloperoxidase (MPO) were significantly lower than that of the BDL group (P < 0.001). The levels of glutathione (GSH) in CAPE treated rats were significantly higher than that of BDL group (P < 0.001). In CAPE treated group, the levels of interleukin-1alpha (IL-1α) and interleukin-6 (IL-6) were significantly lower than that of BDL group (P < 0.03, P < 0.02, respectively). Administration of CAPE in the rats with biliary obstruction resulted in inhibition of necro-inflammation. Conclusion These results suggest that treatment of CAPE maintains antioxidant defenses, reduces oxidative liver injury, cytokine damage, and necro-inflammation in bile duct ligated rats. Thus, CAPE seems to be a promising agent for the attenuation of cholestatic liver injury. Caffeic acid phenethyl ester (CAPE) has been subjected to considerable investigations that have revealed its antioxidant and anti-inflammatory activities in different conditions. But there is not a previous investigation about its effect on cholestatic liver injury. The aim of this study was to investigate the effect of CAPE in rat liver against cholestatic liver injury induced by bile duct ligation. Swiss-albino rats were recruited in the study as follows; Group 1 rats subjected to simple laparotomy known as the sham group; Group 2 rats subjected to bile duct ligation (BDL); Group 3 bile duct ligated rats treated with CAPE. The third group received CAPE (10 μmol/kg) intraperitoneally daily throughout 14 d. Data showed a decrease in γ glutamyl transferase (GGT), aspartate aminotransferase (AST), and alanine aminotransferase levels (ALT) of the CAPE treated rats, compared with BDL group (P < 0.001, P < 0.01, and P < 0.02, respectively). In the CAPE treated rats, tissue levels of malondialdehyde (MDA) and myeloperoxidase (MPO) were significantly lower than that of the BDL group (P < 0.001). The levels of glutathione (GSH) in CAPE treated rats were significantly higher than that of BDL group (P < 0.001). In CAPE treated group, the levels of interleukin-1alpha (IL-1α) and interleukin-6 (IL-6) were significantly lower than that of BDL group (P < 0.03, P < 0.02, respectively). Administration of CAPE in the rats with biliary obstruction resulted in inhibition of necro-inflammation. These results suggest that treatment of CAPE maintains antioxidant defenses, reduces oxidative liver injury, cytokine damage, and necro-inflammation in bile duct ligated rats. Thus, CAPE seems to be a promising agent for the attenuation of cholestatic liver injury." @default.
• W2103764243 created "2016-06-24" @default.
• W2103764243 creator A5005888201 @default.
• W2103764243 creator A5008373808 @default.
• W2103764243 creator A5015957161 @default.
• W2103764243 creator A5067526691 @default.
• W2103764243 creator A5068921408 @default.
• W2103764243 creator A5076098328 @default.
• W2103764243 creator A5081694535 @default.
• W2103764243 creator A5090656535 @default.
• W2103764243 date "2010-04-01" @default.
• W2103764243 modified "2023-09-23" @default.
• W2103764243 title "The Effect of Caffeic Acid Phenethyl Ester (CAPE) Against Cholestatic Liver Injury in Rats" @default.
• W2103764243 cites W133733527 @default.
• W2103764243 cites W139528081 @default.
• W2103764243 cites W1500173618 @default.
• W2103764243 cites W1503403486 @default.
• W2103764243 cites W1964716875 @default.
• W2103764243 cites W1969794217 @default.
• W2103764243 cites W1978155252 @default.
• W2103764243 cites W1978877941 @default.
• W2103764243 cites W1981743729 @default.
• W2103764243 cites W1981900811 @default.
• W2103764243 cites W1994231705 @default.
• W2103764243 cites W2000368894 @default.
• W2103764243 cites W2010730772 @default.
• W2103764243 cites W2017025371 @default.
• W2103764243 cites W2026933757 @default.
• W2103764243 cites W2035088045 @default.
• W2103764243 cites W2035425626 @default.
• W2103764243 cites W2042300796 @default.
• W2103764243 cites W2044600153 @default.
• W2103764243 cites W2052712793 @default.
• W2103764243 cites W2053054955 @default.
• W2103764243 cites W2064691836 @default.
• W2103764243 cites W2066696233 @default.
• W2103764243 cites W2067428778 @default.
• W2103764243 cites W2074712784 @default.
• W2103764243 cites W2077710302 @default.
• W2103764243 cites W2078244175 @default.
• W2103764243 cites W2081093925 @default.
• W2103764243 cites W2081120437 @default.
• W2103764243 cites W2081977719 @default.
• W2103764243 cites W2083771515 @default.
• W2103764243 cites W2087794733 @default.
• W2103764243 cites W2093134964 @default.
• W2103764243 cites W2095222956 @default.
• W2103764243 cites W2103517120 @default.
• W2103764243 cites W2111232772 @default.
• W2103764243 cites W2115956200 @default.
• W2103764243 cites W2142714198 @default.
• W2103764243 cites W2142731081 @default.
• W2103764243 cites W2157488207 @default.
• W2103764243 cites W2287664140 @default.
• W2103764243 cites W3145945047 @default.
• W2103764243 doi "https://doi.org/10.1016/j.jss.2008.10.023" @default.
• W2103764243 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/19535096" @default.
• W2103764243 hasPublicationYear "2010" @default.
• W2103764243 type Work @default.
• W2103764243 sameAs 2103764243 @default.
• W2103764243 citedByCount "18" @default.
• W2103764243 countsByYear W21037642432012 @default.
• W2103764243 countsByYear W21037642432013 @default.
• W2103764243 countsByYear W21037642432015 @default.
• W2103764243 countsByYear W21037642432016 @default.
• W2103764243 countsByYear W21037642432017 @default.
• W2103764243 countsByYear W21037642432019 @default.
• W2103764243 crossrefType "journal-article" @default.
• W2103764243 hasAuthorship W2103764243A5005888201 @default.
• W2103764243 hasAuthorship W2103764243A5008373808 @default.
• W2103764243 hasAuthorship W2103764243A5015957161 @default.
• W2103764243 hasAuthorship W2103764243A5067526691 @default.
• W2103764243 hasAuthorship W2103764243A5068921408 @default.
• W2103764243 hasAuthorship W2103764243A5076098328 @default.
• W2103764243 hasAuthorship W2103764243A5081694535 @default.
• W2103764243 hasAuthorship W2103764243A5090656535 @default.
• W2103764243 hasConcept C126322002 @default.
• W2103764243 hasConcept C134018914 @default.
• W2103764243 hasConcept C181199279 @default.
• W2103764243 hasConcept C185592680 @default.
• W2103764243 hasConcept C203565725 @default.
• W2103764243 hasConcept C2776151105 @default.
• W2103764243 hasConcept C2776637226 @default.
• W2103764243 hasConcept C2776914184 @default.
• W2103764243 hasConcept C2776992468 @default.
• W2103764243 hasConcept C2778004101 @default.
• W2103764243 hasConcept C2778224086 @default.
• W2103764243 hasConcept C2778401633 @default.
• W2103764243 hasConcept C2779777945 @default.
• W2103764243 hasConcept C538909803 @default.
• W2103764243 hasConcept C55493867 @default.
• W2103764243 hasConcept C71924100 @default.
• W2103764243 hasConcept C90924648 @default.
• W2103764243 hasConcept C98274493 @default.
• W2103764243 hasConceptScore W2103764243C126322002 @default.
• W2103764243 hasConceptScore W2103764243C134018914 @default.
• W2103764243 hasConceptScore W2103764243C181199279 @default.
• W2103764243 hasConceptScore W2103764243C185592680 @default.

• next