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- W2103770333 abstract "Homology-directed repair of DNA damage has recently emerged as a major mechanism for the maintenance of genomic integrity in mammalian cells. The highly conserved strand transferase, Rad51, is expected to be critical for this process. XRCC3 possesses a limited sequence similarity to Rad51 and interacts with it. Using a novel fluorescence-based assay, we demonstrate here that error-free homology-directed repair of DNA double-strand breaks is decreased 25-fold in an XRCC3-deficient hamster cell line and can be restored to wild-type levels through XRCC3 expression. These results establish that XRCC3-mediated homologous recombination can reverse DNA damage that would otherwise be mutagenic or lethal." @default.
- W2103770333 created "2016-06-24" @default.
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- W2103770333 date "1999-10-15" @default.
- W2103770333 modified "2023-10-09" @default.
- W2103770333 title "XRCC3 promotes homology-directed repair of DNA damage in mammalian cells" @default.
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- W2103770333 doi "https://doi.org/10.1101/gad.13.20.2633" @default.
- W2103770333 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/317094" @default.
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