FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2103791567> ?p ?o ?g. }

• W2103791567 endingPage "3939" @default.
• W2103791567 startingPage "3933" @default.
• W2103791567 abstract "Previous investigations, in vitro, have demonstrated that progestins can induce the transcription of the cell cycle regulator, cyclin D1, thereby suggesting that cyclin D1 may mediate, at the molecular level, the proposed mitogenic effects of progesterone during mammary epithelial cell proliferation. To extend these initial studies into an in vivo context, comparative cyclin D1 Northern and immunohistochemical analyses were performed on mammary gland tissue isolated from wild type (WT) females as well as from the recently reported progesterone receptor knockout (PRKO) mouse model. Northern analysis revealed that estrogen induced cyclin D1 expression, 5- to 7-fold over control levels, both in the WT and PRKO female. Immunohistochemistry demonstrated that, for both test groups, the number of mammary epithelial cells expressing cyclin D1 increased significantly as compared with control values, in response to estrogen. In the case of estrogen plus progesterone treatment, Northern analysis revealed that, in the WT gland, cyclin D1 transcription increased approximately 3-fold over estrogen induced levels, an increase that was paralleled by an equivalent increase in the number of mammary epithelial cells expressing cyclin D1. Conversely, under the same hormone regimen, the PRKO mammary gland did not exhibit a further increase in cyclin D1 induction over estrogen only levels. Finally, these studies not only demonstrate that in the mammary epithelial cell, both estrogen and progesterone can induce the expression of cyclin D1 but also show that this induction correlates with mammary gland proliferation in the mouse." @default.
• W2103791567 created "2016-06-24" @default.
• W2103791567 creator A5005545965 @default.
• W2103791567 creator A5029537735 @default.
• W2103791567 creator A5035110273 @default.
• W2103791567 creator A5057978718 @default.
• W2103791567 creator A5064070422 @default.
• W2103791567 date "1997-09-01" @default.
• W2103791567 modified "2023-10-17" @default.
• W2103791567 title "Progesterone, in Addition to Estrogen, Induces Cyclin D1 Expression in the Murine Mammary Epithelial Cell, in Vivo*" @default.
• W2103791567 cites W1981325896 @default.
• W2103791567 cites W2004391147 @default.
• W2103791567 cites W2019663821 @default.
• W2103791567 cites W2034290334 @default.
• W2103791567 cites W2054097897 @default.
• W2103791567 cites W2056357500 @default.
• W2103791567 cites W2057559331 @default.
• W2103791567 cites W2058705034 @default.
• W2103791567 cites W2068482620 @default.
• W2103791567 cites W2072794518 @default.
• W2103791567 cites W2078596153 @default.
• W2103791567 cites W2082559087 @default.
• W2103791567 cites W2088782232 @default.
• W2103791567 cites W2088938008 @default.
• W2103791567 cites W2095565562 @default.
• W2103791567 cites W2099134569 @default.
• W2103791567 cites W2121664015 @default.
• W2103791567 cites W2401522950 @default.
• W2103791567 doi "https://doi.org/10.1210/endo.138.9.5436" @default.
• W2103791567 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/9275084" @default.
• W2103791567 hasPublicationYear "1997" @default.
• W2103791567 type Work @default.
• W2103791567 sameAs 2103791567 @default.
• W2103791567 citedByCount "83" @default.
• W2103791567 countsByYear W21037915672012 @default.
• W2103791567 countsByYear W21037915672013 @default.
• W2103791567 countsByYear W21037915672014 @default.
• W2103791567 countsByYear W21037915672015 @default.
• W2103791567 countsByYear W21037915672016 @default.
• W2103791567 countsByYear W21037915672017 @default.
• W2103791567 countsByYear W21037915672018 @default.
• W2103791567 countsByYear W21037915672019 @default.
• W2103791567 countsByYear W21037915672020 @default.
• W2103791567 countsByYear W21037915672021 @default.
• W2103791567 countsByYear W21037915672022 @default.
• W2103791567 crossrefType "journal-article" @default.
• W2103791567 hasAuthorship W2103791567A5005545965 @default.
• W2103791567 hasAuthorship W2103791567A5029537735 @default.
• W2103791567 hasAuthorship W2103791567A5035110273 @default.
• W2103791567 hasAuthorship W2103791567A5057978718 @default.
• W2103791567 hasAuthorship W2103791567A5064070422 @default.
• W2103791567 hasBestOaLocation W21037915671 @default.
• W2103791567 hasConcept C11882975 @default.
• W2103791567 hasConcept C120089663 @default.
• W2103791567 hasConcept C121608353 @default.
• W2103791567 hasConcept C126322002 @default.
• W2103791567 hasConcept C134018914 @default.
• W2103791567 hasConcept C16438837 @default.
• W2103791567 hasConcept C199835354 @default.
• W2103791567 hasConcept C2777164284 @default.
• W2103791567 hasConcept C2778001805 @default.
• W2103791567 hasConcept C29537977 @default.
• W2103791567 hasConcept C530470458 @default.
• W2103791567 hasConcept C54355233 @default.
• W2103791567 hasConcept C62112901 @default.
• W2103791567 hasConcept C71924100 @default.
• W2103791567 hasConcept C84606932 @default.
• W2103791567 hasConcept C86803240 @default.
• W2103791567 hasConcept C94561458 @default.
• W2103791567 hasConcept C9743823 @default.
• W2103791567 hasConcept C98717036 @default.
• W2103791567 hasConceptScore W2103791567C11882975 @default.
• W2103791567 hasConceptScore W2103791567C120089663 @default.
• W2103791567 hasConceptScore W2103791567C121608353 @default.
• W2103791567 hasConceptScore W2103791567C126322002 @default.
• W2103791567 hasConceptScore W2103791567C134018914 @default.
• W2103791567 hasConceptScore W2103791567C16438837 @default.
• W2103791567 hasConceptScore W2103791567C199835354 @default.
• W2103791567 hasConceptScore W2103791567C2777164284 @default.
• W2103791567 hasConceptScore W2103791567C2778001805 @default.
• W2103791567 hasConceptScore W2103791567C29537977 @default.
• W2103791567 hasConceptScore W2103791567C530470458 @default.
• W2103791567 hasConceptScore W2103791567C54355233 @default.
• W2103791567 hasConceptScore W2103791567C62112901 @default.
• W2103791567 hasConceptScore W2103791567C71924100 @default.
• W2103791567 hasConceptScore W2103791567C84606932 @default.
• W2103791567 hasConceptScore W2103791567C86803240 @default.
• W2103791567 hasConceptScore W2103791567C94561458 @default.
• W2103791567 hasConceptScore W2103791567C9743823 @default.
• W2103791567 hasConceptScore W2103791567C98717036 @default.
• W2103791567 hasIssue "9" @default.
• W2103791567 hasLocation W21037915671 @default.
• W2103791567 hasLocation W21037915672 @default.
• W2103791567 hasOpenAccess W2103791567 @default.
• W2103791567 hasPrimaryLocation W21037915671 @default.
• W2103791567 hasRelatedWork W1493334928 @default.
• W2103791567 hasRelatedWork W1621533677 @default.
• W2103791567 hasRelatedWork W1971698113 @default.

• next