FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2103793224> ?p ?o ?g. }

• W2103793224 abstract "Background: EphA2 is a receptor tyrosine kinase of the Eph family, which regulates angiogenesis, cell growth, survival and migration. EphA2 targeting has been proposed as a novel therapeutic strategy for neoplasms that overexpress this protein, particularly in case of resistance to VEGF-targeted therapy. This work raised the question whether EphA2 expression would be a predictive factor in patients with metastatic renal cell carcinoma (RCC) treated with VEGF inhibitors. Methods: We analyzed the levels of EphA2 protein expression by immunohistochemistry in specimens of 23 patients with metastatic RCC, which were postsurgically treated with Anti-VEGF-therapy. The quantification of EphA2 protein expression was performed by automated digital image analysis using the open source software ImageJ. Statistical analysis using Cox proportional hazard modeling, Bayesian information criterion (BIC) statistic and Kendall’s tau ( τ ) correlation was done using the program R. Results: The expression of EphA2 correlated significantly with the histological grading (correlation coefficient Kendall’s τ =0.52; p <0.05 for grades II and III). High levels of EphA2 expression levels by the adjacent kidney tissue of RCC tumors had a positive predictive value for overall survival, suggesting a tumor suppressive effect of EphA2 expressed in the tumor surrounding tissue. We also found a negative correlation between the EphA2 expression level in the primary tumor and the matching metastasis. These findings implicate different dominating signaling pathways in the primary tumor and its metastasis, with consequently a need for a complex therapeutic approach. Conclusions: Our study suggests an association between EphA2 receptor expression and RCC carcinogenesis and metastasis. The differential effects of EphA2 signaling, from a tumor suppressive to a tumor promoting role, are greatly dependent upon its precise localization: In addition to its previously described tumor promoting role in EphA2 overexpressing tumors we observed an association between high levels of EphA2 in the adjacent normal kidney tissue and survival, suggesting a tumor suppressive role. An improved understanding of the different tasks of EphA2 signaling in the primary tumors, their surrounding tissues and metastases may be of benefit for a better targeting of metastatic RCC." @default.
• W2103793224 created "2016-06-24" @default.
• W2103793224 creator A5045808892 @default.
• W2103793224 creator A5047705108 @default.
• W2103793224 creator A5072299016 @default.
• W2103793224 date "2013-03-26" @default.
• W2103793224 modified "2023-10-03" @default.
• W2103793224 title "EphA2 protein expression in metastatic renal cell carcinoma treated with VEGF-inhibitors is predictive of patient survival" @default.
• W2103793224 cites W1524233852 @default.
• W2103793224 cites W1595998158 @default.
• W2103793224 cites W1967113969 @default.
• W2103793224 cites W1989847300 @default.
• W2103793224 cites W1996131261 @default.
• W2103793224 cites W2000027123 @default.
• W2103793224 cites W2000151901 @default.
• W2103793224 cites W2023826034 @default.
• W2103793224 cites W2030694827 @default.
• W2103793224 cites W2034993026 @default.
• W2103793224 cites W2035609206 @default.
• W2103793224 cites W2036519126 @default.
• W2103793224 cites W2045105439 @default.
• W2103793224 cites W2073599411 @default.
• W2103793224 cites W2083185728 @default.
• W2103793224 cites W2083458091 @default.
• W2103793224 cites W2083927895 @default.
• W2103793224 cites W2092311035 @default.
• W2103793224 cites W2094637061 @default.
• W2103793224 cites W2094663537 @default.
• W2103793224 cites W2099752220 @default.
• W2103793224 cites W2104662981 @default.
• W2103793224 cites W2105772211 @default.
• W2103793224 cites W2109167795 @default.
• W2103793224 cites W2112875738 @default.
• W2103793224 cites W2115155004 @default.
• W2103793224 cites W2123467604 @default.
• W2103793224 cites W2127190481 @default.
• W2103793224 cites W2130828569 @default.
• W2103793224 cites W2132464112 @default.
• W2103793224 cites W2136472366 @default.
• W2103793224 cites W2137525036 @default.
• W2103793224 cites W2139429540 @default.
• W2103793224 cites W2141444851 @default.
• W2103793224 cites W2145365512 @default.
• W2103793224 cites W2152055261 @default.
• W2103793224 cites W2163314408 @default.
• W2103793224 cites W2170665989 @default.
• W2103793224 cites W2171573054 @default.
• W2103793224 cites W2171974712 @default.
• W2103793224 cites W2770637926 @default.
• W2103793224 doi "https://doi.org/10.5430/jst.v3n3p12" @default.
• W2103793224 hasPublicationYear "2013" @default.
• W2103793224 type Work @default.
• W2103793224 sameAs 2103793224 @default.
• W2103793224 citedByCount "0" @default.
• W2103793224 crossrefType "journal-article" @default.
• W2103793224 hasAuthorship W2103793224A5045808892 @default.
• W2103793224 hasAuthorship W2103793224A5047705108 @default.
• W2103793224 hasAuthorship W2103793224A5072299016 @default.
• W2103793224 hasBestOaLocation W21037932241 @default.
• W2103793224 hasConcept C101544691 @default.
• W2103793224 hasConcept C121608353 @default.
• W2103793224 hasConcept C126322002 @default.
• W2103793224 hasConcept C142724271 @default.
• W2103793224 hasConcept C143998085 @default.
• W2103793224 hasConcept C150582083 @default.
• W2103793224 hasConcept C170493617 @default.
• W2103793224 hasConcept C193270364 @default.
• W2103793224 hasConcept C204232928 @default.
• W2103793224 hasConcept C2777472916 @default.
• W2103793224 hasConcept C2779013556 @default.
• W2103793224 hasConcept C2780394083 @default.
• W2103793224 hasConcept C502942594 @default.
• W2103793224 hasConcept C71924100 @default.
• W2103793224 hasConceptScore W2103793224C101544691 @default.
• W2103793224 hasConceptScore W2103793224C121608353 @default.
• W2103793224 hasConceptScore W2103793224C126322002 @default.
• W2103793224 hasConceptScore W2103793224C142724271 @default.
• W2103793224 hasConceptScore W2103793224C143998085 @default.
• W2103793224 hasConceptScore W2103793224C150582083 @default.
• W2103793224 hasConceptScore W2103793224C170493617 @default.
• W2103793224 hasConceptScore W2103793224C193270364 @default.
• W2103793224 hasConceptScore W2103793224C204232928 @default.
• W2103793224 hasConceptScore W2103793224C2777472916 @default.
• W2103793224 hasConceptScore W2103793224C2779013556 @default.
• W2103793224 hasConceptScore W2103793224C2780394083 @default.
• W2103793224 hasConceptScore W2103793224C502942594 @default.
• W2103793224 hasConceptScore W2103793224C71924100 @default.
• W2103793224 hasIssue "3" @default.
• W2103793224 hasLocation W21037932241 @default.
• W2103793224 hasOpenAccess W2103793224 @default.
• W2103793224 hasPrimaryLocation W21037932241 @default.
• W2103793224 hasRelatedWork W1966290213 @default.
• W2103793224 hasRelatedWork W2116227441 @default.
• W2103793224 hasRelatedWork W2358565899 @default.
• W2103793224 hasRelatedWork W2791088259 @default.
• W2103793224 hasRelatedWork W2996521565 @default.
• W2103793224 hasRelatedWork W3082611839 @default.
• W2103793224 hasRelatedWork W3114532332 @default.
• W2103793224 hasRelatedWork W3175984978 @default.
• W2103793224 hasRelatedWork W4311669536 @default.

• next