Matches in SemOpenAlex for { <https://semopenalex.org/work/W2103799963> ?p ?o ?g. }
- W2103799963 endingPage "4973" @default.
- W2103799963 startingPage "4964" @default.
- W2103799963 abstract "Abstract Purpose: As an approach to evaluate the expression pattern and status of activation of signaling pathways in clinical specimens from head and neck squamous cell carcinoma (HNSCC) patients, we established the Head and Neck Cancer Tissue Array Initiative, an international consortium aimed at developing a high-density HNSCC tissue microarray, with a high representation of oral squamous cell carcinoma. Experimental Design: These tissue arrays were constructed by acquiring cylindrical biopsies from multiple individual tumor tissues and transferring them into tissue microarray blocks. From a total of 1,300 cases, 547 cores, including controls, were selected and used to build the array. Results: Emerging information by the use of phosphospecific antibodies detecting the activated state of signaling molecules indicates that the Akt-mammalian target of rapamycin (mTOR) pathway is frequently activated in HNSCC, but independently from the activation of epidermal growth factor receptor or the detection of mutant p53. Indeed, we identified a large group of tissue samples displaying active Akt and mTOR in the absence of epidermal growth factor receptor activation. Furthermore, we have also identified a small subgroup of patients in which the mTOR pathway is activated but not Akt, suggesting the existence of an Akt-independent signaling route stimulating mTOR. Conclusions: These findings provide important information about the nature of the dysregulated signaling networks in HNSCC and may also provide the rationale for the future development of novel mechanism-based therapies for HNSCC patients." @default.
- W2103799963 created "2016-06-24" @default.
- W2103799963 creator A5003240871 @default.
- W2103799963 creator A5004650215 @default.
- W2103799963 creator A5005145715 @default.
- W2103799963 creator A5009328221 @default.
- W2103799963 creator A5011055578 @default.
- W2103799963 creator A5016565717 @default.
- W2103799963 creator A5020442027 @default.
- W2103799963 creator A5021506059 @default.
- W2103799963 creator A5038753309 @default.
- W2103799963 creator A5039639408 @default.
- W2103799963 creator A5041486680 @default.
- W2103799963 creator A5044436091 @default.
- W2103799963 creator A5044625569 @default.
- W2103799963 creator A5047912678 @default.
- W2103799963 creator A5049579503 @default.
- W2103799963 creator A5059135827 @default.
- W2103799963 creator A5059504870 @default.
- W2103799963 creator A5066463949 @default.
- W2103799963 creator A5068893773 @default.
- W2103799963 creator A5085754827 @default.
- W2103799963 creator A5087543035 @default.
- W2103799963 creator A5089840478 @default.
- W2103799963 date "2007-09-01" @default.
- W2103799963 modified "2023-10-16" @default.
- W2103799963 title "Dissecting the Akt/Mammalian Target of Rapamycin Signaling Network: Emerging Results from the Head and Neck Cancer Tissue Array Initiative" @default.
- W2103799963 cites W1480254704 @default.
- W2103799963 cites W1668086213 @default.
- W2103799963 cites W1788218796 @default.
- W2103799963 cites W1964099867 @default.
- W2103799963 cites W1970179765 @default.
- W2103799963 cites W1972301619 @default.
- W2103799963 cites W1979171324 @default.
- W2103799963 cites W1984493254 @default.
- W2103799963 cites W1988184140 @default.
- W2103799963 cites W1996460785 @default.
- W2103799963 cites W2000639509 @default.
- W2103799963 cites W2011104583 @default.
- W2103799963 cites W2016116775 @default.
- W2103799963 cites W2016503230 @default.
- W2103799963 cites W2025383700 @default.
- W2103799963 cites W2026037248 @default.
- W2103799963 cites W2027450812 @default.
- W2103799963 cites W2029523063 @default.
- W2103799963 cites W2035849572 @default.
- W2103799963 cites W2036254130 @default.
- W2103799963 cites W2036941567 @default.
- W2103799963 cites W2040863351 @default.
- W2103799963 cites W2047057570 @default.
- W2103799963 cites W2050980183 @default.
- W2103799963 cites W2056891806 @default.
- W2103799963 cites W2058183377 @default.
- W2103799963 cites W2064810566 @default.
- W2103799963 cites W2072566577 @default.
- W2103799963 cites W2081184407 @default.
- W2103799963 cites W2083158752 @default.
- W2103799963 cites W2084951542 @default.
- W2103799963 cites W2087810003 @default.
- W2103799963 cites W2089195710 @default.
- W2103799963 cites W2089663915 @default.
- W2103799963 cites W2090060692 @default.
- W2103799963 cites W2090861745 @default.
- W2103799963 cites W2098895289 @default.
- W2103799963 cites W2106660927 @default.
- W2103799963 cites W2109983355 @default.
- W2103799963 cites W2111726305 @default.
- W2103799963 cites W2115100370 @default.
- W2103799963 cites W2117263216 @default.
- W2103799963 cites W2120138780 @default.
- W2103799963 cites W2120259492 @default.
- W2103799963 cites W2122185071 @default.
- W2103799963 cites W2125237084 @default.
- W2103799963 cites W2129585918 @default.
- W2103799963 cites W2138010881 @default.
- W2103799963 cites W2145211249 @default.
- W2103799963 cites W2146950496 @default.
- W2103799963 cites W2147191052 @default.
- W2103799963 cites W2151172155 @default.
- W2103799963 cites W2154376727 @default.
- W2103799963 cites W2160082612 @default.
- W2103799963 cites W2162724777 @default.
- W2103799963 cites W2165264849 @default.
- W2103799963 cites W2167010784 @default.
- W2103799963 cites W2167500143 @default.
- W2103799963 cites W2169490414 @default.
- W2103799963 cites W2312732552 @default.
- W2103799963 cites W2383259826 @default.
- W2103799963 cites W344384229 @default.
- W2103799963 cites W4251326994 @default.
- W2103799963 cites W4297094029 @default.
- W2103799963 cites W4376453790 @default.
- W2103799963 doi "https://doi.org/10.1158/1078-0432.ccr-07-1041" @default.
- W2103799963 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/17785546" @default.
- W2103799963 hasPublicationYear "2007" @default.
- W2103799963 type Work @default.
- W2103799963 sameAs 2103799963 @default.
- W2103799963 citedByCount "211" @default.