Matches in SemOpenAlex for { <https://semopenalex.org/work/W2103803923> ?p ?o ?g. }
- W2103803923 endingPage "19309" @default.
- W2103803923 startingPage "19291" @default.
- W2103803923 abstract "Compound K (CK), a highly active and bioavailable derivative obtained from protopanaxadiol ginsenosides, displays a wide variety of pharmacological properties, especially antitumor activity. However, the inadequacy of natural sources limits its application in the pharmaceutical industry. In this study, we firstly discovered that Cordyceps sinensis was a potent biocatalyst for the biotransformation of ginsenoside Rb1 into CK. After a series of investigations on the biotransformation parameters, an optimal composition of the biotransformation culture was found to be lactose, soybean powder and MgSO₄ without controlling the pH. Also, an optimum temperature of 30 °C for the biotransformation process was suggested in a range of 25 °C-50 °C. Then, a biotransformation pathway of Rb1→Rd→F2→CK was established using high performance liquid chromatography/quadrupole time-of-flight mass spectrometry (HPLC-Q-TOF-MS). Our results demonstrated that the molar bioconversion rate of Rb1 to CK was more than 82% and the purity of CK produced by C. sinensis under the optimized conditions was more than 91%. In conclusion, the combination of C. sinensis and the optimized conditions is applicable for the industrial preparation of CK for medicinal purposes." @default.
- W2103803923 created "2016-06-24" @default.
- W2103803923 creator A5001407510 @default.
- W2103803923 creator A5013337466 @default.
- W2103803923 creator A5028052734 @default.
- W2103803923 creator A5052540993 @default.
- W2103803923 creator A5070986142 @default.
- W2103803923 creator A5073795706 @default.
- W2103803923 date "2015-10-23" @default.
- W2103803923 modified "2023-09-26" @default.
- W2103803923 title "Highly Selective Bioconversion of Ginsenoside Rb1 to Compound K by the Mycelium of Cordyceps sinensis under Optimized Conditions" @default.
- W2103803923 cites W1563892911 @default.
- W2103803923 cites W1584098091 @default.
- W2103803923 cites W1942403353 @default.
- W2103803923 cites W1951109489 @default.
- W2103803923 cites W1967093089 @default.
- W2103803923 cites W1967735445 @default.
- W2103803923 cites W1975714310 @default.
- W2103803923 cites W1979333413 @default.
- W2103803923 cites W1986812607 @default.
- W2103803923 cites W1990119075 @default.
- W2103803923 cites W1991483657 @default.
- W2103803923 cites W1991941639 @default.
- W2103803923 cites W1997786059 @default.
- W2103803923 cites W1999656664 @default.
- W2103803923 cites W2005502138 @default.
- W2103803923 cites W2008349620 @default.
- W2103803923 cites W2010448370 @default.
- W2103803923 cites W2029235307 @default.
- W2103803923 cites W2032412826 @default.
- W2103803923 cites W2035847667 @default.
- W2103803923 cites W2039452757 @default.
- W2103803923 cites W2039763289 @default.
- W2103803923 cites W2040303856 @default.
- W2103803923 cites W2042828837 @default.
- W2103803923 cites W2046401757 @default.
- W2103803923 cites W2048848534 @default.
- W2103803923 cites W2053656819 @default.
- W2103803923 cites W2054407742 @default.
- W2103803923 cites W2060293792 @default.
- W2103803923 cites W2061704018 @default.
- W2103803923 cites W2062284967 @default.
- W2103803923 cites W2063534194 @default.
- W2103803923 cites W2070742194 @default.
- W2103803923 cites W2075541841 @default.
- W2103803923 cites W2080402431 @default.
- W2103803923 cites W2092330826 @default.
- W2103803923 cites W2095307857 @default.
- W2103803923 cites W2130246697 @default.
- W2103803923 cites W2134595618 @default.
- W2103803923 cites W2136511491 @default.
- W2103803923 cites W2147157289 @default.
- W2103803923 cites W2315943908 @default.
- W2103803923 cites W2324845973 @default.
- W2103803923 cites W2400697989 @default.
- W2103803923 cites W2461300149 @default.
- W2103803923 doi "https://doi.org/10.3390/molecules201019291" @default.
- W2103803923 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/6332142" @default.
- W2103803923 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/26512632" @default.
- W2103803923 hasPublicationYear "2015" @default.
- W2103803923 type Work @default.
- W2103803923 sameAs 2103803923 @default.
- W2103803923 citedByCount "14" @default.
- W2103803923 countsByYear W21038039232016 @default.
- W2103803923 countsByYear W21038039232017 @default.
- W2103803923 countsByYear W21038039232018 @default.
- W2103803923 countsByYear W21038039232019 @default.
- W2103803923 countsByYear W21038039232020 @default.
- W2103803923 countsByYear W21038039232021 @default.
- W2103803923 countsByYear W21038039232022 @default.
- W2103803923 crossrefType "journal-article" @default.
- W2103803923 hasAuthorship W2103803923A5001407510 @default.
- W2103803923 hasAuthorship W2103803923A5013337466 @default.
- W2103803923 hasAuthorship W2103803923A5028052734 @default.
- W2103803923 hasAuthorship W2103803923A5052540993 @default.
- W2103803923 hasAuthorship W2103803923A5070986142 @default.
- W2103803923 hasAuthorship W2103803923A5073795706 @default.
- W2103803923 hasBestOaLocation W21038039231 @default.
- W2103803923 hasConcept C100544194 @default.
- W2103803923 hasConcept C133479454 @default.
- W2103803923 hasConcept C142724271 @default.
- W2103803923 hasConcept C181199279 @default.
- W2103803923 hasConcept C185592680 @default.
- W2103803923 hasConcept C204787440 @default.
- W2103803923 hasConcept C2776539398 @default.
- W2103803923 hasConcept C2777032962 @default.
- W2103803923 hasConcept C2779085617 @default.
- W2103803923 hasConcept C2779232237 @default.
- W2103803923 hasConcept C2780074830 @default.
- W2103803923 hasConcept C27881333 @default.
- W2103803923 hasConcept C31903555 @default.
- W2103803923 hasConcept C43617362 @default.
- W2103803923 hasConcept C55493867 @default.
- W2103803923 hasConcept C59822182 @default.
- W2103803923 hasConcept C71924100 @default.
- W2103803923 hasConcept C86803240 @default.
- W2103803923 hasConceptScore W2103803923C100544194 @default.
- W2103803923 hasConceptScore W2103803923C133479454 @default.