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- W2103804905 abstract "By employing a new competitive proteinbindingassay described in the previous paper, serum levels of the somatomedin designated as nonsuppressible insulin-like activity (NSILA) have been measured in normal individuals and patients with disorders of GH secretion, both under basal and altered conditions of carbohydrate metabolism. In addition, serum NSILA levels have been determined in several species of laboratory animals (mouse, rat, rabbit, dog, and sheep). Evidence that serum NSILA is GH-dependent is provided by the finding that the mean (± SEM) level in 11 acromegalics (1136 ± 60/μU/ml) is significantly higher (P < 0.001) and the mean level in 8 hypopituitary patients (408 ± 30 μU/ml) is significantly lower (P < 0.001) than that in 14 normal subjects (836 ± 21 μU/ml).Also, after the administration of human GH to three hypopituitary patients, the mean NSILA level rose from a baseline of 409 ± 108 /μU/ml to 628 ± 48 μU/ml. Serum NSILA levels were not significantly changed either by insulin-induced hypogly..." @default.
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- W2103804905 date "1978-04-01" @default.
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- W2103804905 title "Nonsuppressible Insulin-Like Activity (NSILA).II. Regulation of Serum Concentrations by Growth Hormone and Insulin*" @default.
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- W2103804905 doi "https://doi.org/10.1210/jcem-46-4-672" @default.
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