FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2103806952> ?p ?o ?g. }

• W2103806952 endingPage "3104" @default.
• W2103806952 startingPage "3095" @default.
• W2103806952 abstract "Abstract High impulsivity, mediated through ventral striatal dopamine signalling, represents an established risk factor for substance abuse, and may likewise confer vulnerability to pathological overeating. Mechanistically, the assumption is that trait impulsivity facilitates the initiation of maladaptive eating styles or choices. However, whether consumption of appetitive macronutrients themselves causes deficits in impulse control and striatal signalling, thereby contributing to cognitive changes permissive of overeating behaviour, has yet to be considered. We examined the effects of chronic maintenance on restricted equicaloric, but high‐fat or high‐sugar, diets (48 kcal/day; 60 kcal% fat or sucrose) on rats’ performance in the five‐choice serial reaction time task, indexing impulsivity and attention. Markers of dopamine signalling in the dorsal and ventral striatum, and plasma insulin and leptin levels, were also assessed. Rats maintained on the high‐fat diet ( HFD ) were more impulsive, whereas the high‐sugar diet ( HSD ) did not alter task performance. Importantly, body weight and hormone levels were similar between groups when behavioural changes were observed. Maintenance on HFD , but not on HSD , reduced the levels of dopamine D 2 receptor (D 2 R), cAMP response element‐binding protein ( CREB ) and phosphophorylated CREB (Ser133) proteins in the ventral, but not dorsal, striatum. D 2 R expression in the ventral striatum also negatively correlated with impulsive responding, independently of diet. These data indicate that chronic exposure to even limited amounts of high‐fat foods may weaken impulse control and alter neural signalling in a manner associated with vulnerability to addictions – findings that have serious implications for the propagation of uncontrolled eating behaviour in obesity and binge‐eating disorder." @default.
• W2103806952 created "2016-06-24" @default.
• W2103806952 creator A5001597821 @default.
• W2103806952 creator A5032695877 @default.
• W2103806952 creator A5035201080 @default.
• W2103806952 creator A5036263560 @default.
• W2103806952 creator A5037815249 @default.
• W2103806952 creator A5077442988 @default.
• W2103806952 date "2015-12-01" @default.
• W2103806952 modified "2023-10-11" @default.
• W2103806952 title "Long‐term, calorie‐restricted intake of a high‐fat diet in rats reduces impulse control and ventral striatal D₂ receptor signalling – two markers of addiction vulnerability" @default.
• W2103806952 cites W117137915 @default.
• W2103806952 cites W1510812756 @default.
• W2103806952 cites W1785939209 @default.
• W2103806952 cites W1823012060 @default.
• W2103806952 cites W1890680756 @default.
• W2103806952 cites W1963874618 @default.
• W2103806952 cites W1966148872 @default.
• W2103806952 cites W1968417706 @default.
• W2103806952 cites W1971190603 @default.
• W2103806952 cites W1972649416 @default.
• W2103806952 cites W1973621674 @default.
• W2103806952 cites W1980557031 @default.
• W2103806952 cites W1980800464 @default.
• W2103806952 cites W1983332126 @default.
• W2103806952 cites W1985107350 @default.
• W2103806952 cites W1985334763 @default.
• W2103806952 cites W1985570109 @default.
• W2103806952 cites W1988386723 @default.
• W2103806952 cites W1989014835 @default.
• W2103806952 cites W1992615559 @default.
• W2103806952 cites W1993518191 @default.
• W2103806952 cites W1994043330 @default.
• W2103806952 cites W1994383563 @default.
• W2103806952 cites W1998763917 @default.
• W2103806952 cites W2000780784 @default.
• W2103806952 cites W2001203903 @default.
• W2103806952 cites W2004470044 @default.
• W2103806952 cites W2008233347 @default.
• W2103806952 cites W2009115510 @default.
• W2103806952 cites W2012775787 @default.
• W2103806952 cites W2015575539 @default.
• W2103806952 cites W2016677234 @default.
• W2103806952 cites W2017712441 @default.
• W2103806952 cites W2027496959 @default.
• W2103806952 cites W2028127185 @default.
• W2103806952 cites W2029087047 @default.
• W2103806952 cites W2035001090 @default.
• W2103806952 cites W2036620114 @default.
• W2103806952 cites W2040376657 @default.
• W2103806952 cites W2042963919 @default.
• W2103806952 cites W2044991544 @default.
• W2103806952 cites W2045326150 @default.
• W2103806952 cites W2045451128 @default.
• W2103806952 cites W2045572233 @default.
• W2103806952 cites W2051681662 @default.
• W2103806952 cites W2053544091 @default.
• W2103806952 cites W2054111217 @default.
• W2103806952 cites W2055391686 @default.
• W2103806952 cites W2056448740 @default.
• W2103806952 cites W2060356116 @default.
• W2103806952 cites W2062879497 @default.
• W2103806952 cites W2064936475 @default.
• W2103806952 cites W2069303582 @default.
• W2103806952 cites W2070780907 @default.
• W2103806952 cites W2072021328 @default.
• W2103806952 cites W2073752229 @default.
• W2103806952 cites W2073832840 @default.
• W2103806952 cites W2073999182 @default.
• W2103806952 cites W2075171259 @default.
• W2103806952 cites W2079671995 @default.
• W2103806952 cites W2080796480 @default.
• W2103806952 cites W2082078342 @default.
• W2103806952 cites W2082758383 @default.
• W2103806952 cites W2088113970 @default.
• W2103806952 cites W2092703117 @default.
• W2103806952 cites W2093110870 @default.
• W2103806952 cites W2093453410 @default.
• W2103806952 cites W2097744565 @default.
• W2103806952 cites W2099440512 @default.
• W2103806952 cites W2107440671 @default.
• W2103806952 cites W2109386189 @default.
• W2103806952 cites W2121614675 @default.
• W2103806952 cites W2121889285 @default.
• W2103806952 cites W2132751606 @default.
• W2103806952 cites W2139885605 @default.
• W2103806952 cites W2149823377 @default.
• W2103806952 cites W2154458038 @default.
• W2103806952 cites W2167512478 @default.
• W2103806952 cites W2173939482 @default.
• W2103806952 cites W4319293047 @default.
• W2103806952 doi "https://doi.org/10.1111/ejn.13117" @default.
• W2103806952 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/26527415" @default.
• W2103806952 hasPublicationYear "2015" @default.
• W2103806952 type Work @default.
• W2103806952 sameAs 2103806952 @default.
• W2103806952 citedByCount "68" @default.
• W2103806952 countsByYear W21038069522016 @default.

• next