FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2103807764> ?p ?o ?g. }

• W2103807764 endingPage "741" @default.
• W2103807764 startingPage "732" @default.
• W2103807764 abstract "Ussing chambers are commonly utilized for in vitro investigations into gastrointestinal permeability. However, their sensitivity and applicability to the small intestine have not been well characterized.In order to investigate the effects of experimentally induced damage and the relative contribution of the mucosa and muscularis externa layers to transmural permeability in the small intestine, stomach and colon, normal rat intestinal tissues were mounted in Ussing chambers with or without removal of the muscularis externa or mucosal layers. Gastric tissues were damaged in vivo by exposure to indomethacin (100 mg kg(-1)), while ileal tissues were damaged in vitro by 0.4 M NaCl. Tissue damage was assessed histologically, while permeability parameters included conductance (G), potential difference (PD) and mucosal to serosal flux of horseradish peroxidase (HRP).Damage localized to the tissue edges (edge damage) accounted for 25%-50% of the exposed epithelial length in the ileum, while less than 20% of stomach and colon epithelium was affected by edge damage. In the damaged stomach, a 20% reduction in epithelialization was accompanied by increases in G (P < 0.001) and HRP (P < 0.01) flux. Removal of the muscularis externa did not affect mucosal viability in the undamaged ileum or colon although HRP flux in the colon, but not ileum, was increased (P < 0.01). Removal of the ileal mucosa produced increases in G and HRP flux, while PD was maintained.We conclude that the Ussing chamber technique is suitable for application to studies of gastric and colonic permeability in rats. However, owing to the prevalence and extent of edge damage in the small intestine, we would caution against the use of this technique for permeability studies in this region of the gastrointestinal tract in the rat." @default.
• W2103807764 created "2016-06-24" @default.
• W2103807764 creator A5056331522 @default.
• W2103807764 creator A5070940983 @default.
• W2103807764 creator A5071400581 @default.
• W2103807764 creator A5074220590 @default.
• W2103807764 creator A5074512491 @default.
• W2103807764 date "2003-01-01" @default.
• W2103807764 modified "2023-09-27" @default.
• W2103807764 title "Applicability of the Ussing Chamber Technique to Permeability Determinations in Functionally Distinct Regions of the Gastrointestinal Tract in the Rat" @default.
• W2103807764 cites W151789264 @default.
• W2103807764 cites W1870487270 @default.
• W2103807764 cites W1965563675 @default.
• W2103807764 cites W1972525652 @default.
• W2103807764 cites W1982332941 @default.
• W2103807764 cites W2000029278 @default.
• W2103807764 cites W2021580001 @default.
• W2103807764 cites W2030136078 @default.
• W2103807764 cites W2041051298 @default.
• W2103807764 cites W2046650434 @default.
• W2103807764 cites W2049267500 @default.
• W2103807764 cites W2061017694 @default.
• W2103807764 cites W2067092097 @default.
• W2103807764 cites W2078579326 @default.
• W2103807764 cites W2089624109 @default.
• W2103807764 cites W2095147460 @default.
• W2103807764 cites W2119129945 @default.
• W2103807764 cites W2119318194 @default.
• W2103807764 cites W2120662329 @default.
• W2103807764 cites W2144247614 @default.
• W2103807764 cites W2156865162 @default.
• W2103807764 cites W2159640265 @default.
• W2103807764 cites W2165003157 @default.
• W2103807764 cites W2172273019 @default.
• W2103807764 cites W2178596618 @default.
• W2103807764 cites W2276836401 @default.
• W2103807764 cites W2396561639 @default.
• W2103807764 cites W2416219064 @default.
• W2103807764 cites W2435304172 @default.
• W2103807764 cites W2466255648 @default.
• W2103807764 cites W2015319691 @default.
• W2103807764 doi "https://doi.org/10.1080/00365520310003101" @default.
• W2103807764 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/12889559" @default.
• W2103807764 hasPublicationYear "2003" @default.
• W2103807764 type Work @default.
• W2103807764 sameAs 2103807764 @default.
• W2103807764 citedByCount "30" @default.
• W2103807764 countsByYear W21038077642012 @default.
• W2103807764 countsByYear W21038077642013 @default.
• W2103807764 countsByYear W21038077642015 @default.
• W2103807764 countsByYear W21038077642016 @default.
• W2103807764 countsByYear W21038077642018 @default.
• W2103807764 countsByYear W21038077642019 @default.
• W2103807764 countsByYear W21038077642021 @default.
• W2103807764 crossrefType "journal-article" @default.
• W2103807764 hasAuthorship W2103807764A5056331522 @default.
• W2103807764 hasAuthorship W2103807764A5070940983 @default.
• W2103807764 hasAuthorship W2103807764A5071400581 @default.
• W2103807764 hasAuthorship W2103807764A5074220590 @default.
• W2103807764 hasAuthorship W2103807764A5074512491 @default.
• W2103807764 hasConcept C105702510 @default.
• W2103807764 hasConcept C120882062 @default.
• W2103807764 hasConcept C126322002 @default.
• W2103807764 hasConcept C134018914 @default.
• W2103807764 hasConcept C142724271 @default.
• W2103807764 hasConcept C181199279 @default.
• W2103807764 hasConcept C185592680 @default.
• W2103807764 hasConcept C2776280935 @default.
• W2103807764 hasConcept C2777226302 @default.
• W2103807764 hasConcept C2777676563 @default.
• W2103807764 hasConcept C2777882243 @default.
• W2103807764 hasConcept C2777960253 @default.
• W2103807764 hasConcept C2779422922 @default.
• W2103807764 hasConcept C2779932011 @default.
• W2103807764 hasConcept C2780512811 @default.
• W2103807764 hasConcept C2781071285 @default.
• W2103807764 hasConcept C41625074 @default.
• W2103807764 hasConcept C529295009 @default.
• W2103807764 hasConcept C55493867 @default.
• W2103807764 hasConcept C71924100 @default.
• W2103807764 hasConcept C86803240 @default.
• W2103807764 hasConceptScore W2103807764C105702510 @default.
• W2103807764 hasConceptScore W2103807764C120882062 @default.
• W2103807764 hasConceptScore W2103807764C126322002 @default.
• W2103807764 hasConceptScore W2103807764C134018914 @default.
• W2103807764 hasConceptScore W2103807764C142724271 @default.
• W2103807764 hasConceptScore W2103807764C181199279 @default.
• W2103807764 hasConceptScore W2103807764C185592680 @default.
• W2103807764 hasConceptScore W2103807764C2776280935 @default.
• W2103807764 hasConceptScore W2103807764C2777226302 @default.
• W2103807764 hasConceptScore W2103807764C2777676563 @default.
• W2103807764 hasConceptScore W2103807764C2777882243 @default.
• W2103807764 hasConceptScore W2103807764C2777960253 @default.
• W2103807764 hasConceptScore W2103807764C2779422922 @default.
• W2103807764 hasConceptScore W2103807764C2779932011 @default.
• W2103807764 hasConceptScore W2103807764C2780512811 @default.
• W2103807764 hasConceptScore W2103807764C2781071285 @default.
• W2103807764 hasConceptScore W2103807764C41625074 @default.

• next