FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2103809436> ?p ?o ?g. }

• W2103809436 abstract "ABSTRACT We carried out multilocus sequence typing (MLST) on 148 pneumococcal carriage isolates collected from children <24 months old in the Upper River Division, the Gambia. MLST revealed a diverse population. Seventy-six different sequence types (STs) were found, the most common of which were 802 and 919, associated with 23F and 6A serotypes, respectively. Comparison with the MLST database showed that only 11 of the STs found in the present sample had been reported outside Africa. Six STs showed evidence of capsular switching (172, 802, 847, 1730, 1736, and 1737). Serotype switches were confirmed by microarrays that detected capsule genes. Of isolates analyzed by using microarrays, 40/69 (58%) harbored the tetM resistance determinant. A statistical genetic analysis to detect recombination found that 49/144 (34%) isolates showed significant ( P < 0.05) evidence of admixture, which is greater than that observed in similar samples from the United Kingdom (5%) and Finland (2%). We hypothesize that large amounts of admixture could reflect the high prevalence of multiple carriage in this region, leading to more opportunities for homologous recombination between strains. This could have consequences for the population response to conjugate vaccination. IMPORTANCE The population structure of the pneumococcus in sub-Saharan Africa has barely been studied despite the high levels of morbidity and mortality due to pneumococcal disease in this region. We report the largest sample to date from carriage in sub-Saharan Africa to be typed by sequencing (multilocus sequence typing [MLST]) and microarray analysis. The results clearly show that the population is highly distinct and divergent from others studied in the United States and Europe. Moreover, in contrast with samples from developed countries, the population contains a high proportion of isolates showing a history of homologous recombination, which shuffles genetic information into new combinations and can generate drug-resistant and vaccine escape strains. This is likely to have important consequences for the evolutionary response of the pneumococcal population to conjugate vaccination targeting a subset of pneumococcal serotypes, which is under way in the Gambia and other countries." @default.
• W2103809436 created "2016-06-24" @default.
• W2103809436 creator A5002658344 @default.
• W2103809436 creator A5004694078 @default.
• W2103809436 creator A5012921982 @default.
• W2103809436 creator A5023116254 @default.
• W2103809436 creator A5026129407 @default.
• W2103809436 creator A5040018261 @default.
• W2103809436 creator A5090401686 @default.
• W2103809436 date "2011-07-01" @default.
• W2103809436 modified "2023-09-29" @default.
• W2103809436 title "High Levels of Recombination among Streptococcus pneumoniae Isolates from the Gambia" @default.
• W2103809436 cites W1886810706 @default.
• W2103809436 cites W1975277416 @default.
• W2103809436 cites W1976695860 @default.
• W2103809436 cites W1985690296 @default.
• W2103809436 cites W1995788221 @default.
• W2103809436 cites W2014974296 @default.
• W2103809436 cites W2037409969 @default.
• W2103809436 cites W2039902501 @default.
• W2103809436 cites W2044812603 @default.
• W2103809436 cites W2046044972 @default.
• W2103809436 cites W2049956598 @default.
• W2103809436 cites W2055782637 @default.
• W2103809436 cites W2061292121 @default.
• W2103809436 cites W2068383131 @default.
• W2103809436 cites W2082475697 @default.
• W2103809436 cites W2098332275 @default.
• W2103809436 cites W2101218683 @default.
• W2103809436 cites W2105008621 @default.
• W2103809436 cites W2106353408 @default.
• W2103809436 cites W2109126905 @default.
• W2103809436 cites W2111716378 @default.
• W2103809436 cites W2121369371 @default.
• W2103809436 cites W2121861720 @default.
• W2103809436 cites W2125121305 @default.
• W2103809436 cites W2132000476 @default.
• W2103809436 cites W2134606926 @default.
• W2103809436 cites W2138663192 @default.
• W2103809436 cites W2142012650 @default.
• W2103809436 cites W2149652290 @default.
• W2103809436 cites W2154300732 @default.
• W2103809436 cites W2156956165 @default.
• W2103809436 cites W2158569411 @default.
• W2103809436 cites W2160667747 @default.
• W2103809436 cites W2166597151 @default.
• W2103809436 doi "https://doi.org/10.1128/mbio.00040-11" @default.
• W2103809436 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/3119534" @default.
• W2103809436 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/21693638" @default.
• W2103809436 hasPublicationYear "2011" @default.
• W2103809436 type Work @default.
• W2103809436 sameAs 2103809436 @default.
• W2103809436 citedByCount "27" @default.
• W2103809436 countsByYear W21038094362012 @default.
• W2103809436 countsByYear W21038094362013 @default.
• W2103809436 countsByYear W21038094362014 @default.
• W2103809436 countsByYear W21038094362015 @default.
• W2103809436 countsByYear W21038094362016 @default.
• W2103809436 countsByYear W21038094362017 @default.
• W2103809436 countsByYear W21038094362018 @default.
• W2103809436 countsByYear W21038094362019 @default.
• W2103809436 countsByYear W21038094362021 @default.
• W2103809436 countsByYear W21038094362022 @default.
• W2103809436 countsByYear W21038094362023 @default.
• W2103809436 crossrefType "journal-article" @default.
• W2103809436 hasAuthorship W2103809436A5002658344 @default.
• W2103809436 hasAuthorship W2103809436A5004694078 @default.
• W2103809436 hasAuthorship W2103809436A5012921982 @default.
• W2103809436 hasAuthorship W2103809436A5023116254 @default.
• W2103809436 hasAuthorship W2103809436A5026129407 @default.
• W2103809436 hasAuthorship W2103809436A5040018261 @default.
• W2103809436 hasAuthorship W2103809436A5090401686 @default.
• W2103809436 hasBestOaLocation W21038094363 @default.
• W2103809436 hasConcept C10389963 @default.
• W2103809436 hasConcept C104317684 @default.
• W2103809436 hasConcept C135763542 @default.
• W2103809436 hasConcept C142724271 @default.
• W2103809436 hasConcept C2778866548 @default.
• W2103809436 hasConcept C2781209916 @default.
• W2103809436 hasConcept C2781253189 @default.
• W2103809436 hasConcept C2908647359 @default.
• W2103809436 hasConcept C32762888 @default.
• W2103809436 hasConcept C523546767 @default.
• W2103809436 hasConcept C54355233 @default.
• W2103809436 hasConcept C71924100 @default.
• W2103809436 hasConcept C77434933 @default.
• W2103809436 hasConcept C86803240 @default.
• W2103809436 hasConcept C89423630 @default.
• W2103809436 hasConcept C99454951 @default.
• W2103809436 hasConceptScore W2103809436C10389963 @default.
• W2103809436 hasConceptScore W2103809436C104317684 @default.
• W2103809436 hasConceptScore W2103809436C135763542 @default.
• W2103809436 hasConceptScore W2103809436C142724271 @default.
• W2103809436 hasConceptScore W2103809436C2778866548 @default.
• W2103809436 hasConceptScore W2103809436C2781209916 @default.
• W2103809436 hasConceptScore W2103809436C2781253189 @default.
• W2103809436 hasConceptScore W2103809436C2908647359 @default.
• W2103809436 hasConceptScore W2103809436C32762888 @default.
• W2103809436 hasConceptScore W2103809436C523546767 @default.
• W2103809436 hasConceptScore W2103809436C54355233 @default.

• next