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- W2103815008 abstract "The AAA (ATPase associated with various cellular activities) ATPase, p97, is a hexameric protein of chaperone-like function, which has been reported to interact with a number of proteins of seemingly unrelated functions. For the first time, we report a classification of these proteins and aim to elucidate any common structural or functional features they may share. The interactors are grouped into those containing ubiquitin regulatory X domains, which presumably bind to p97 in the same way as the p47 adaptor, and into non-ubiquitin regulatory X domain proteins of different functional subgroups that may employ a different mode of interaction (assuming they also bind directly to p97 and are not experimental artifacts). Future studies will show whether interacting proteins direct p97 to different cellular pathways or a common one and structural elucidation of these interactions will be crucial in understanding these underlying functions." @default.
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- W2103815008 date "2004-10-26" @default.
- W2103815008 modified "2023-10-14" @default.
- W2103815008 title "p97 and close encounters of every kind: a brief review" @default.
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- W2103815008 doi "https://doi.org/10.1042/bst0320715" @default.
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