FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2103820120> ?p ?o ?g. }

• W2103820120 endingPage "18" @default.
• W2103820120 startingPage "18" @default.
• W2103820120 abstract "Tau protein exists as six different isoforms that differ by the inclusion or exclusion of exons 2, 3 and 10. Exon 10 encodes a microtubule binding repeat, thereby resulting in three isoforms with three microtubule binding repeats (3R) and three isoforms that have four microtubule binding repeats (4R). In normal adult brain, the relative amounts of 3R tau and 4R tau are approximately equal. These relative protein levels are preserved in Alzheimer's disease, although in other neurodegenerative tauopathies such as progressive supranuclear palsy, corticobasal degeneration and Pick's disease, the ratio of 3R:4R is frequently altered. Because tau isoforms are not equally involved in these diseases, it is possible that they either have inherently unique characteristics owing to their primary structures or that post-translational modification, such as phosphorylation, differentially affects their properties. We have determined the effects of phosphorylation by a kinase widely believed to be involved in neurodegenerative processes, glycogen synthase kinase-3β (GSK-3β), on the microtubule binding and inducer-initiated polymerization of these isoforms in vitro. We have found that each isoform has a unique microtubule binding and polymerization profile that is altered by GSK-3β. GSK-3β phosphorylation had differential effects on the isoforms although there were similarities between isoforms and the effects were generally mild. These results indicate that tau phosphorylation by a single kinase can have isoform specific outcomes. The mild nature of these changes, however, makes it unlikely that differential effects of GSK-3β phosphorylation on the isoforms are causative in neurodegenerative disease. Instead, the inherent differences in the isoform interactions themselves and local conditions in the diseased cells are likely the major determinant of isoform involvement in various neurodegenerative disorders." @default.
• W2103820120 created "2016-06-24" @default.
• W2103820120 creator A5013043957 @default.
• W2103820120 creator A5057847965 @default.
• W2103820120 date "2009-01-01" @default.
• W2103820120 modified "2023-10-17" @default.
• W2103820120 title "GSK-3β phosphorylation of functionally distinct tau isoforms has differential, but mild effects" @default.
• W2103820120 cites W1481130297 @default.
• W2103820120 cites W1501075116 @default.
• W2103820120 cites W1532265037 @default.
• W2103820120 cites W1927347955 @default.
• W2103820120 cites W1970049032 @default.
• W2103820120 cites W1971775491 @default.
• W2103820120 cites W1974322112 @default.
• W2103820120 cites W1975700794 @default.
• W2103820120 cites W1983769449 @default.
• W2103820120 cites W1984770038 @default.
• W2103820120 cites W1985002125 @default.
• W2103820120 cites W1985215040 @default.
• W2103820120 cites W1995895492 @default.
• W2103820120 cites W1996103311 @default.
• W2103820120 cites W1997942761 @default.
• W2103820120 cites W1998440070 @default.
• W2103820120 cites W2006051211 @default.
• W2103820120 cites W2013013393 @default.
• W2103820120 cites W2021415958 @default.
• W2103820120 cites W2021914048 @default.
• W2103820120 cites W2041655987 @default.
• W2103820120 cites W2065961022 @default.
• W2103820120 cites W2079100944 @default.
• W2103820120 cites W2081451333 @default.
• W2103820120 cites W2084816054 @default.
• W2103820120 cites W2087745495 @default.
• W2103820120 cites W2092502645 @default.
• W2103820120 cites W2103913931 @default.
• W2103820120 cites W2114358785 @default.
• W2103820120 cites W2114415876 @default.
• W2103820120 cites W2139553041 @default.
• W2103820120 cites W2157972442 @default.
• W2103820120 cites W2159643400 @default.
• W2103820120 cites W2165988981 @default.
• W2103820120 doi "https://doi.org/10.1186/1750-1326-4-18" @default.
• W2103820120 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/2683827" @default.
• W2103820120 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/19409104" @default.
• W2103820120 hasPublicationYear "2009" @default.
• W2103820120 type Work @default.
• W2103820120 sameAs 2103820120 @default.
• W2103820120 citedByCount "26" @default.
• W2103820120 countsByYear W21038201202012 @default.
• W2103820120 countsByYear W21038201202013 @default.
• W2103820120 countsByYear W21038201202015 @default.
• W2103820120 countsByYear W21038201202016 @default.
• W2103820120 countsByYear W21038201202020 @default.
• W2103820120 countsByYear W21038201202022 @default.
• W2103820120 countsByYear W21038201202023 @default.
• W2103820120 crossrefType "journal-article" @default.
• W2103820120 hasAuthorship W2103820120A5013043957 @default.
• W2103820120 hasAuthorship W2103820120A5057847965 @default.
• W2103820120 hasBestOaLocation W21038201201 @default.
• W2103820120 hasConcept C104317684 @default.
• W2103820120 hasConcept C11960822 @default.
• W2103820120 hasConcept C121738310 @default.
• W2103820120 hasConcept C126322002 @default.
• W2103820120 hasConcept C182996813 @default.
• W2103820120 hasConcept C184235292 @default.
• W2103820120 hasConcept C185592680 @default.
• W2103820120 hasConcept C194583182 @default.
• W2103820120 hasConcept C20418707 @default.
• W2103820120 hasConcept C2776477761 @default.
• W2103820120 hasConcept C2776925932 @default.
• W2103820120 hasConcept C2778670691 @default.
• W2103820120 hasConcept C2779134260 @default.
• W2103820120 hasConcept C2781172350 @default.
• W2103820120 hasConcept C36823959 @default.
• W2103820120 hasConcept C502032728 @default.
• W2103820120 hasConcept C53345823 @default.
• W2103820120 hasConcept C54355233 @default.
• W2103820120 hasConcept C55493867 @default.
• W2103820120 hasConcept C71924100 @default.
• W2103820120 hasConcept C82495950 @default.
• W2103820120 hasConcept C86803240 @default.
• W2103820120 hasConcept C95444343 @default.
• W2103820120 hasConcept C97029542 @default.
• W2103820120 hasConceptScore W2103820120C104317684 @default.
• W2103820120 hasConceptScore W2103820120C11960822 @default.
• W2103820120 hasConceptScore W2103820120C121738310 @default.
• W2103820120 hasConceptScore W2103820120C126322002 @default.
• W2103820120 hasConceptScore W2103820120C182996813 @default.
• W2103820120 hasConceptScore W2103820120C184235292 @default.
• W2103820120 hasConceptScore W2103820120C185592680 @default.
• W2103820120 hasConceptScore W2103820120C194583182 @default.
• W2103820120 hasConceptScore W2103820120C20418707 @default.
• W2103820120 hasConceptScore W2103820120C2776477761 @default.
• W2103820120 hasConceptScore W2103820120C2776925932 @default.
• W2103820120 hasConceptScore W2103820120C2778670691 @default.
• W2103820120 hasConceptScore W2103820120C2779134260 @default.
• W2103820120 hasConceptScore W2103820120C2781172350 @default.
• W2103820120 hasConceptScore W2103820120C36823959 @default.

• next