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• W2103833136 abstract "The particle size characteristics and encapsulation efficiency of microparticles prepared using triglyceride materials and loaded with two model water-soluble drugs were evaluated. Two emulsification procedures based on o/w and w/o/w methodologies were compared to a novel spray congealing procedure. After extensive modification of both emulsification methods, encapsulation efficiencies of 13.04% tetracycline HCl and 11.27% lidocaine HCl were achievable in a Witepsol-based microparticle. This compares to much improved encapsulation efficiencies close to 100% for the spray congealing method, which was shown to produce spherical particles of approximately 58 microm. Drug release studies from a Witepsol formulation loaded with lidocaine HCl showed a temperature-dependent release mechanism, which displayed diffusion-controlled kinetics at temperatures approximately 25 degrees C, but exhibited almost immediate release when triggered using temperatures close to that of skin. Therefore, such a system may find application in topical semi-solid formulations, where a temperature-induced burst release is preferred." @default.
• W2103833136 created "2016-06-24" @default.
• W2103833136 creator A5035668087 @default.
• W2103833136 creator A5086012798 @default.
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• W2103833136 date "2008-01-01" @default.
• W2103833136 modified "2023-10-16" @default.
• W2103833136 title "Comparison of a novel spray congealing procedure with emulsion-based methods for the micro-encapsulation of water-soluble drugs in low melting point triglycerides" @default.
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• W2103833136 doi "https://doi.org/10.1080/02652040802000656" @default.
• W2103833136 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/18465298" @default.
• W2103833136 hasPublicationYear "2008" @default.
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