FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2103833483> ?p ?o ?g. }

• W2103833483 endingPage "2537" @default.
• W2103833483 startingPage "2531" @default.
• W2103833483 abstract "β-Adrenergic receptor (AR) blockers provide substantial clinical benefits, including improving overall survival and left ventricular (LV) function following myocardial infarction (MI), though the mechanisms remain incompletely defined. The transverse-tubule (T-tubule) system of ventricular myocytes is an important determinant of cardiac excitation-contraction function. T-tubule remodeling occurs early during LV failure. We hypothesized that β-AR blockers prevent T-tubule remodeling and thereby provide therapeutic benefits. A murine model of MI was utilized to examine the effect of β-AR blockers on T-tubule remodeling following LV MI. We applied the in situ imaging of T-tubule structure from Langendorff-perfused intact hearts with laser scanning confocal microscopy. We found that MI caused remarkable T-tubule remodeling near the infarction border zone and moderate LV remodeling remote from the MI. Metoprolol and carvedilol administered 6 d after MI for 4 wk each increased the T-tubule integrity at the remote and border zones. At the molecular level, both β-AR blockers restored border and remote zone expression of junctophilin-2 (JP-2), which is involved in T-tubule organization and formation of the T-tubule/sarcoplasmic reticulum junctions. In contrast, β-AR blockers had no significant effects on caveolin-3 expression. In summary, our data show that β-AR antagonists can protect against T-tubule remodeling after MI, suggesting a novel therapeutic mechanism of action for this drug class. Preservation of JP-2 expression may contribute to the beneficial effects of metoprolol and carvedilol on T-tubule remodeling.— Chen, B., Li, Y., Jiang, S., Xie, Y.-P., Guo, A., Kutschke, W., Zimmerman, K., Weiss, R. M., Miller, F. J., Anderson, M. E., Song, L.-S. β-Adrenergic receptor antagonists ameliorate myocyte T-tubule remodeling following myocardial infarction. FASEB J. 26, 2531-2537 (2012). www.fasebj.org" @default.
• W2103833483 created "2016-06-24" @default.
• W2103833483 creator A5004910231 @default.
• W2103833483 creator A5019036513 @default.
• W2103833483 creator A5020712868 @default.
• W2103833483 creator A5033821392 @default.
• W2103833483 creator A5039833068 @default.
• W2103833483 creator A5044367029 @default.
• W2103833483 creator A5046562663 @default.
• W2103833483 creator A5060464452 @default.
• W2103833483 creator A5076195800 @default.
• W2103833483 creator A5078483111 @default.
• W2103833483 creator A5083311495 @default.
• W2103833483 date "2012-02-28" @default.
• W2103833483 modified "2023-10-16" @default.
• W2103833483 title "β‐Adrenergic receptor antagonists ameliorate myocyte T‐tubule remodeling following myocardial infarction" @default.
• W2103833483 cites W1513594647 @default.
• W2103833483 cites W1524057507 @default.
• W2103833483 cites W1605990605 @default.
• W2103833483 cites W1654241318 @default.
• W2103833483 cites W1899532222 @default.
• W2103833483 cites W1963623014 @default.
• W2103833483 cites W1980862725 @default.
• W2103833483 cites W1992540995 @default.
• W2103833483 cites W1994316999 @default.
• W2103833483 cites W2001261561 @default.
• W2103833483 cites W2017596484 @default.
• W2103833483 cites W2020587550 @default.
• W2103833483 cites W2021693681 @default.
• W2103833483 cites W2022607662 @default.
• W2103833483 cites W2022901757 @default.
• W2103833483 cites W2023884139 @default.
• W2103833483 cites W2024629940 @default.
• W2103833483 cites W2053584873 @default.
• W2103833483 cites W2056982707 @default.
• W2103833483 cites W2059315994 @default.
• W2103833483 cites W2065866662 @default.
• W2103833483 cites W2080975798 @default.
• W2103833483 cites W2088940841 @default.
• W2103833483 cites W2091583229 @default.
• W2103833483 cites W2093015794 @default.
• W2103833483 cites W2093109507 @default.
• W2103833483 cites W2104367313 @default.
• W2103833483 cites W2106972592 @default.
• W2103833483 cites W2109665703 @default.
• W2103833483 cites W2125089577 @default.
• W2103833483 cites W2125738242 @default.
• W2103833483 cites W2132323819 @default.
• W2103833483 cites W2140368058 @default.
• W2103833483 cites W2143034673 @default.
• W2103833483 cites W2145582089 @default.
• W2103833483 cites W2146567904 @default.
• W2103833483 cites W2147445745 @default.
• W2103833483 cites W2155271904 @default.
• W2103833483 cites W2157288569 @default.
• W2103833483 cites W2161214266 @default.
• W2103833483 cites W2170853736 @default.
• W2103833483 cites W2172025889 @default.
• W2103833483 cites W3023522280 @default.
• W2103833483 cites W4235408016 @default.
• W2103833483 doi "https://doi.org/10.1096/fj.11-199505" @default.
• W2103833483 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/3360148" @default.
• W2103833483 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/22375019" @default.
• W2103833483 hasPublicationYear "2012" @default.
• W2103833483 type Work @default.
• W2103833483 sameAs 2103833483 @default.
• W2103833483 citedByCount "58" @default.
• W2103833483 countsByYear W21038334832012 @default.
• W2103833483 countsByYear W21038334832013 @default.
• W2103833483 countsByYear W21038334832014 @default.
• W2103833483 countsByYear W21038334832015 @default.
• W2103833483 countsByYear W21038334832016 @default.
• W2103833483 countsByYear W21038334832017 @default.
• W2103833483 countsByYear W21038334832018 @default.
• W2103833483 countsByYear W21038334832019 @default.
• W2103833483 countsByYear W21038334832020 @default.
• W2103833483 countsByYear W21038334832021 @default.
• W2103833483 countsByYear W21038334832022 @default.
• W2103833483 countsByYear W21038334832023 @default.
• W2103833483 crossrefType "journal-article" @default.
• W2103833483 hasAuthorship W2103833483A5004910231 @default.
• W2103833483 hasAuthorship W2103833483A5019036513 @default.
• W2103833483 hasAuthorship W2103833483A5020712868 @default.
• W2103833483 hasAuthorship W2103833483A5033821392 @default.
• W2103833483 hasAuthorship W2103833483A5039833068 @default.
• W2103833483 hasAuthorship W2103833483A5044367029 @default.
• W2103833483 hasAuthorship W2103833483A5046562663 @default.
• W2103833483 hasAuthorship W2103833483A5060464452 @default.
• W2103833483 hasAuthorship W2103833483A5076195800 @default.
• W2103833483 hasAuthorship W2103833483A5078483111 @default.
• W2103833483 hasAuthorship W2103833483A5083311495 @default.
• W2103833483 hasBestOaLocation W21038334831 @default.
• W2103833483 hasConcept C126322002 @default.
• W2103833483 hasConcept C134018914 @default.
• W2103833483 hasConcept C164705383 @default.
• W2103833483 hasConcept C185592680 @default.
• W2103833483 hasConcept C207200792 @default.
• W2103833483 hasConcept C2778198053 @default.

• next