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• W2103843657 abstract "Background: Nitrous oxide rapidly inflates gas‐filled spaces such as the intestines; but whether the resulting bowel distension is clinically important remains unclear. We therefore tested the hypothesis that nitrous oxide produces clinically important bowel distension. Methods: Patients scheduled for colon resection were anesthetized with isoflurane and 35% oxygen and randomly assigned to 65% nitrous oxide ( n = 175) or 65% nitrogen in air ( n = 169). At the end of surgery, blinded surgeons rated the degree of bowel distension as none, mild, moderate, or severe. Patients reported pain, and nausea and vomiting (PONV) 2 h after surgery. Data are reported as means (SD). P < 0.05 was statistically significant. Results: Morphometric and demographic data were similar in the groups. The duration of surgery was 3.0 (1.2) h in the nitrous oxide group and 3.4 (1.5) h in the air group ( P = 0.017). Postoperative self‐reported pain scores (visual analog scale, 0–100 mm) were greater in the nitrous oxide group (43 [30] mm) than in the air group (35 [31] mm, P = 0.018). Although the incidence of PONV was similar in the groups, VAS scores for nausea were significantly greater in the nitrous oxide group ( P = 0.040). Moderate‐to‐severe bowel distension was observed in 23% of nitrous oxide patients, but in only 9% of patients in the air group ( P < 0.001). The number‐needed‐to‐harm for moderate or severe bowel distension from nitrous oxide was thus seven. Conclusions: Our results suggest that avoiding nitrous oxide administration during prolonged bowel operations will minimize bowel distension and possibly reduce postoperative pain related to it." @default.
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• W2103843657 date "2004-07-09" @default.
• W2103843657 modified "2023-10-15" @default.
• W2103843657 title "Nitrous oxide increases the incidence of bowel distension in patients undergoing elective colon resection" @default.
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• W2103843657 doi "https://doi.org/10.1111/j.0001-5172.2004.00427.x" @default.
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