FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2103850139> ?p ?o ?g. }

• W2103850139 endingPage "691" @default.
• W2103850139 startingPage "684" @default.
• W2103850139 abstract "The present study examined the role of tissue inhibitors of metalloproteinases ITIMPs) in tissue remodeling that occurs during luteal development and regression throughout pseudopregnancy in the rat. Pseudopregnancy was induced in immature female rats by eCG/ hCG priming. Animals (n = 4 per time point) were killed on Days 1, 2, 4, 8, 12, 14, and 16 of pseudopregnancy (post hCG administration), and ovaries were removed and analyzed for metalloproteinase inhibitor activity or TIMP-1, TIMP-2, and TIMP-3 mRNA expression. Inhibitory activity was highest in Day-1 samples (41.35 ± 6.50 inhibitory units), and inhibitor activity significantly decreased ( p < 0.05) thereafter to minimal values at Day 12 (8.14 ± 2.71 inhibitory units). Methylamine hydrochloride treatment, which inactivates macroglobulin-type inhibitors, revealed that the majority of the inhibitor activity in the Day-1 samples (82.6%) and the Day-16 samples (77.3%) could be attributed to TIMPs. To further distinguish the contribution of each TIMP to this activity, Northern analysis for TIMP-1, −2, and −3 was performed. Analysis of TIMP mRNA expression revealed that TIMP-1 transcript expression was highest (p = 0.00009) at Day 1, decreased approximately 3- to 20-fold from Days 2 to 12, respectively, and again increased at Days 14–16. However, TIMP-2 expression did not change (p > 0.05) over any of the time points studied. In contrast to TIMP-1 and TIMP-2 expression, TIMP-3 mRNA expression was lowest during Days 1 and 2 of pseudopregnancy, increased approximately 4-fold at Day 4, peaked at Day 8, and remained elevated throughout the remainder of pseudopregnancy. We conclude from these studies that TIMPs play a role in the regulation of connective tissue remodeling associated with luteal development and regression. Furthermore, the distinct pattern of expression of the three TIMPs suggests that each may regulate either the site and extent of proteolytic action or specific matrix metalloproteinases at different periods of the luteal life span." @default.
• W2103850139 created "2016-06-24" @default.
• W2103850139 creator A5060562558 @default.
• W2103850139 creator A5064828553 @default.
• W2103850139 creator A5067003073 @default.
• W2103850139 creator A5081445796 @default.
• W2103850139 date "1995-09-01" @default.
• W2103850139 modified "2023-10-15" @default.
• W2103850139 title "Expression and Activity of Ovarian Tissue Inhibitors of Metalloproteinases during Pseudopregnancy in the Rat1" @default.
• W2103850139 cites W1530138845 @default.
• W2103850139 cites W1545168990 @default.
• W2103850139 cites W1561618900 @default.
• W2103850139 cites W1564770156 @default.
• W2103850139 cites W1602981281 @default.
• W2103850139 cites W1664158328 @default.
• W2103850139 cites W1669342624 @default.
• W2103850139 cites W1894541755 @default.
• W2103850139 cites W190777749 @default.
• W2103850139 cites W1963499944 @default.
• W2103850139 cites W1978126375 @default.
• W2103850139 cites W1979702523 @default.
• W2103850139 cites W1980186261 @default.
• W2103850139 cites W2000903132 @default.
• W2103850139 cites W2004101410 @default.
• W2103850139 cites W2026749013 @default.
• W2103850139 cites W2032693302 @default.
• W2103850139 cites W2051991758 @default.
• W2103850139 cites W2060333964 @default.
• W2103850139 cites W2079959059 @default.
• W2103850139 cites W2084236205 @default.
• W2103850139 cites W2086964897 @default.
• W2103850139 cites W2093796745 @default.
• W2103850139 cites W2109658199 @default.
• W2103850139 cites W2119050264 @default.
• W2103850139 cites W2128635872 @default.
• W2103850139 cites W2130111495 @default.
• W2103850139 cites W2145154418 @default.
• W2103850139 cites W2146396871 @default.
• W2103850139 cites W2163424852 @default.
• W2103850139 doi "https://doi.org/10.1095/biolreprod53.3.684" @default.
• W2103850139 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/7578694" @default.
• W2103850139 hasPublicationYear "1995" @default.
• W2103850139 type Work @default.
• W2103850139 sameAs 2103850139 @default.
• W2103850139 citedByCount "51" @default.
• W2103850139 countsByYear W21038501392018 @default.
• W2103850139 countsByYear W21038501392022 @default.
• W2103850139 crossrefType "journal-article" @default.
• W2103850139 hasAuthorship W2103850139A5060562558 @default.
• W2103850139 hasAuthorship W2103850139A5064828553 @default.
• W2103850139 hasAuthorship W2103850139A5067003073 @default.
• W2103850139 hasAuthorship W2103850139A5081445796 @default.
• W2103850139 hasBestOaLocation W21038501391 @default.
• W2103850139 hasConcept C104317684 @default.
• W2103850139 hasConcept C105580179 @default.
• W2103850139 hasConcept C109523444 @default.
• W2103850139 hasConcept C126322002 @default.
• W2103850139 hasConcept C134018914 @default.
• W2103850139 hasConcept C16685009 @default.
• W2103850139 hasConcept C2775965246 @default.
• W2103850139 hasConcept C55493867 @default.
• W2103850139 hasConcept C71924100 @default.
• W2103850139 hasConcept C86803240 @default.
• W2103850139 hasConceptScore W2103850139C104317684 @default.
• W2103850139 hasConceptScore W2103850139C105580179 @default.
• W2103850139 hasConceptScore W2103850139C109523444 @default.
• W2103850139 hasConceptScore W2103850139C126322002 @default.
• W2103850139 hasConceptScore W2103850139C134018914 @default.
• W2103850139 hasConceptScore W2103850139C16685009 @default.
• W2103850139 hasConceptScore W2103850139C2775965246 @default.
• W2103850139 hasConceptScore W2103850139C55493867 @default.
• W2103850139 hasConceptScore W2103850139C71924100 @default.
• W2103850139 hasConceptScore W2103850139C86803240 @default.
• W2103850139 hasIssue "3" @default.
• W2103850139 hasLocation W21038501391 @default.
• W2103850139 hasLocation W21038501392 @default.
• W2103850139 hasOpenAccess W2103850139 @default.
• W2103850139 hasPrimaryLocation W21038501391 @default.
• W2103850139 hasRelatedWork W2049658025 @default.
• W2103850139 hasRelatedWork W2088172329 @default.
• W2103850139 hasRelatedWork W2091009027 @default.
• W2103850139 hasRelatedWork W2128503400 @default.
• W2103850139 hasRelatedWork W2141291571 @default.
• W2103850139 hasRelatedWork W2166997892 @default.
• W2103850139 hasRelatedWork W2253165092 @default.
• W2103850139 hasRelatedWork W2384966232 @default.
• W2103850139 hasRelatedWork W2589589 @default.
• W2103850139 hasRelatedWork W2173801710 @default.
• W2103850139 hasVolume "53" @default.
• W2103850139 isParatext "false" @default.
• W2103850139 isRetracted "false" @default.
• W2103850139 magId "2103850139" @default.
• W2103850139 workType "article" @default.