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• W2103857504 abstract "Quantitative properties of the neural system mediating the rewarding and priming effects of medial forebrain bundle (MFB) stimulation in the rat have been determined by experiments that trade one parameter of the electrical stimulus against another. The first-order neurons in this substrate are for the most part long, thin, myelinated axons, coursing in the MFB and ventral tegmentum, with absolute refractory periods in the range .5-1.2 msec and conduction velocities of 2-8 m/sec. Local potentials in these axons decay with a time constant of about .1 msec. A supernormal period follows the recovery from refractoriness. These axons integrate current over exceptionally long intervals, accommodate slowly, and fire on the break of prolonged anodal pulses. These properties rule out the hypothesis that catecholamine pathways constitute the first-order axons. The second-order (postsynaptic) part of the substrate shows surprisingly simple spatial and temporal integrating characteristics. We examine the logic that permits conclusions of this sort to be derived from behavioral data and the role of these derivations in establishing neurobehavioral linkage hypotheses. In this article we describe properties of the neural tissue whose excitation eventuates in the reinforcing and motivating effects of electrical stimulation of the medial forebrain bundle (MFB) in the rat. The goal of the research is to identify these systems by anatomical and electrophysiological methods, thus providing physiological psychology with a model for studying the neurophysiological bases of learning and motivation in a higher vertebrate. The properties of the substrate for selfstimulation described in this article have been inferred from behavioral trade-off experiments—experiments that determine the The authors are listed in alphabetical order. They gratefully acknowledge the following grant support: National Science Foundation Grant BMS-16339 to C. Gallistel; National Institute of Health Grant NS-14935 to C. Gallistel, P. Hand, & M. Reivich; National Institute of Health Training Grant MH15092 (A. Epstein & C. Gallistel, codirectors); Natural Science and Engineering Research Council (NSERC) of Canada Grant A0308 and Quebec Formation des Chercheurs et les Actions Concert6es (FCAC) Grant EQ-09 to P. Shizgal; and NSERC of Canada Grant A7077 to J. Yeomans. Requests for reprints should be sent to C. R. Gallistel," @default.
• W2103857504 created "2016-06-24" @default.
• W2103857504 creator A5020070948 @default.
• W2103857504 creator A5070537984 @default.
• W2103857504 creator A5087434888 @default.
• W2103857504 date "1981-01-01" @default.
• W2103857504 modified "2023-10-17" @default.
• W2103857504 title "A portrait of the substrate for self-stimulation." @default.
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• W2103857504 doi "https://doi.org/10.1037/0033-295x.88.3.228" @default.
• W2103857504 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/6264530" @default.
• W2103857504 hasPublicationYear "1981" @default.
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