Matches in SemOpenAlex for { <https://semopenalex.org/work/W2103886186> ?p ?o ?g. }
- W2103886186 endingPage "21677" @default.
- W2103886186 startingPage "21667" @default.
- W2103886186 abstract "During the early development of the nervous system, γ-aminobutyric acid (GABA) type A receptor (GABA(A)R)-mediated signaling parallels the neurotrophin/tropomyosin-related kinase (Trk)-dependent signaling in controlling a number of processes from cell proliferation and migration, via dendritic and axonal outgrowth, to synapse formation and plasticity. Here we present the first evidence that these two signaling systems regulate each other through a complex positive feedback mechanism. We first demonstrate that GABA(A)R activation leads to an increase in the cell surface expression of these receptors in cultured embryonic cerebrocortical neurons, specifically at the stage when this activity causes depolarization of the plasma membrane and Ca(2+) influx through L-type voltage-gated Ca(2+) channels. We further demonstrate that GABA(A)R activity triggers release of the brain-derived neurotrophic factor (BDNF), which, in turn by activating TrkB receptors, mediates the observed increase in cell surface expression of GABA(A)Rs. This BDNF/TrkB-dependent increase in surface levels of GABA(A)Rs requires the activity of phosphoinositide 3-kinase (PI3K) and protein kinase C (PKC) and does not involve the extracellular signal-regulated kinase (ERK) 1/2 activity. The increase in GABA(A)R surface levels occurs due to an inhibition of the receptor endocytosis by BDNF, whereas the receptor reinsertion into the plasma membrane remains unaltered. Thus, GABA(A)R activity is a potent regulator of the BDNF release during neuronal development, and at the same time, it is strongly enhanced by the activity of the BDNF/TrkB/PI3K/PKC signaling pathway." @default.
- W2103886186 created "2016-06-24" @default.
- W2103886186 creator A5019302200 @default.
- W2103886186 creator A5020338130 @default.
- W2103886186 creator A5023532701 @default.
- W2103886186 creator A5031762065 @default.
- W2103886186 creator A5063244611 @default.
- W2103886186 creator A5073839692 @default.
- W2103886186 creator A5085667675 @default.
- W2103886186 creator A5087099394 @default.
- W2103886186 date "2011-06-01" @default.
- W2103886186 modified "2023-09-26" @default.
- W2103886186 title "Positive Feedback Regulation between γ-Aminobutyric Acid Type A (GABAA) Receptor Signaling and Brain-derived Neurotrophic Factor (BDNF) Release in Developing Neurons" @default.
- W2103886186 cites W1494574304 @default.
- W2103886186 cites W1510360284 @default.
- W2103886186 cites W1529126637 @default.
- W2103886186 cites W1539985358 @default.
- W2103886186 cites W1551663317 @default.
- W2103886186 cites W1575167357 @default.
- W2103886186 cites W1602136552 @default.
- W2103886186 cites W1661938295 @default.
- W2103886186 cites W1705218924 @default.
- W2103886186 cites W1725524769 @default.
- W2103886186 cites W1790244735 @default.
- W2103886186 cites W1814388656 @default.
- W2103886186 cites W1856380311 @default.
- W2103886186 cites W1911923088 @default.
- W2103886186 cites W1912895564 @default.
- W2103886186 cites W1950026089 @default.
- W2103886186 cites W1965770443 @default.
- W2103886186 cites W1970263679 @default.
- W2103886186 cites W1973631822 @default.
- W2103886186 cites W1976495250 @default.
- W2103886186 cites W1979306444 @default.
- W2103886186 cites W1983721130 @default.
- W2103886186 cites W1988533863 @default.
- W2103886186 cites W1989979738 @default.
- W2103886186 cites W1990567359 @default.
- W2103886186 cites W1991545156 @default.
- W2103886186 cites W2000757833 @default.
- W2103886186 cites W2002095654 @default.
- W2103886186 cites W2003313303 @default.
- W2103886186 cites W2004054097 @default.
- W2103886186 cites W2006374396 @default.
- W2103886186 cites W2008492335 @default.
- W2103886186 cites W2010816636 @default.
- W2103886186 cites W2011524968 @default.
- W2103886186 cites W2012423618 @default.
- W2103886186 cites W2017940437 @default.
- W2103886186 cites W2019220811 @default.
- W2103886186 cites W2021228443 @default.
- W2103886186 cites W2024642025 @default.
- W2103886186 cites W2027436298 @default.
- W2103886186 cites W2033045687 @default.
- W2103886186 cites W2035289053 @default.
- W2103886186 cites W2035688483 @default.
- W2103886186 cites W2037335353 @default.
- W2103886186 cites W2037389143 @default.
- W2103886186 cites W2041171950 @default.
- W2103886186 cites W2057531476 @default.
- W2103886186 cites W2060978653 @default.
- W2103886186 cites W2064363302 @default.
- W2103886186 cites W2065171944 @default.
- W2103886186 cites W2065588791 @default.
- W2103886186 cites W2069527370 @default.
- W2103886186 cites W2075208677 @default.
- W2103886186 cites W2085298903 @default.
- W2103886186 cites W2085487753 @default.
- W2103886186 cites W2085602532 @default.
- W2103886186 cites W2087550491 @default.
- W2103886186 cites W2094569799 @default.
- W2103886186 cites W2095802030 @default.
- W2103886186 cites W2099762599 @default.
- W2103886186 cites W2101235918 @default.
- W2103886186 cites W2102329408 @default.
- W2103886186 cites W2106452927 @default.
- W2103886186 cites W2108286207 @default.
- W2103886186 cites W2110722854 @default.
- W2103886186 cites W2112444339 @default.
- W2103886186 cites W2112642058 @default.
- W2103886186 cites W2113971423 @default.
- W2103886186 cites W2117329255 @default.
- W2103886186 cites W2126541199 @default.
- W2103886186 cites W2131993013 @default.
- W2103886186 cites W2133458388 @default.
- W2103886186 cites W2136115516 @default.
- W2103886186 cites W2139582126 @default.
- W2103886186 cites W2145564483 @default.
- W2103886186 cites W2147827183 @default.
- W2103886186 cites W2149858533 @default.
- W2103886186 cites W2153979078 @default.
- W2103886186 cites W2154727263 @default.
- W2103886186 cites W2160205444 @default.
- W2103886186 cites W2160585801 @default.
- W2103886186 cites W2171145595 @default.
- W2103886186 cites W2178107169 @default.
- W2103886186 cites W2924856415 @default.
- W2103886186 doi "https://doi.org/10.1074/jbc.m110.201582" @default.