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- W2103887016 abstract "The life and death of T cells is controlled to a large extent by the relative amounts of Bcl-2-related proteins they contain. The antiapoptotic protein Bcl-2 and the proapoptotic protein Bim are particularly important in this process with the amount of Bcl-2 per cell dropping by about one-half when T cells prepare to die. In this study we show that Bcl-2 and Bim each control the expression of the other. Absence of Bim leads to a drop in the amount of intracellular Bcl-2 protein, while having no effect on the amounts of mRNA for Bcl-2. Conversely, high amounts of Bcl-2 per cell allow high amounts of Bim, although in this case the effect involves increases in Bim mRNA. These mutual effects occur even if Bcl-2 is induced acutely. Thus these two proteins control the expression of the other, at either the protein or mRNA level." @default.
- W2103887016 created "2016-06-24" @default.
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- W2103887016 date "2007-09-15" @default.
- W2103887016 modified "2023-10-16" @default.
- W2103887016 title "Bim and Bcl-2 Mutually Affect the Expression of the Other in T Cells" @default.
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- W2103887016 doi "https://doi.org/10.4049/jimmunol.179.6.3417" @default.
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