FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2103906403> ?p ?o ?g. }

• W2103906403 endingPage "184" @default.
• W2103906403 startingPage "176" @default.
• W2103906403 abstract "Grape seed extracts (GSE) are very potent antioxidant and exhibit numerous interesting pharmacologic activities, including an antioxidant property, and has been suggested to be of use in treatment of several diseases. The present study has been undertaken to investigate the protective and therapeutic effect of GSE against lead-induced neuro and hepatotoxicity in rat. Male albino rats were divided into six groups: the 1st group, rats were injected daily with saline vehicle and served as negative control, the 2nd group (positive control group), the rats were injected (i.p.) with subacute dose (100 mg/kg b·w/day) of lead acetate (LA). The 3rd group (protective group), the rats were injected (i.p.) with LA (100 mg/kg b·w/day) for 7 days after treatment with GSE (100 mg/kg b·w/day) for 3 weeks. The 4th, 5th and 6th groups (therapeutics groups), rats were injected (i.p.) with subacut dose (100 mg/kg b·w/day) of lead acetate for 7 days, then treated with GSE (100 mg/kg b·w/day) for one, two and three weeks, respectively. The level of norepinephrine (NE), dopamine (DA), serotonin (5-HT) and 5-hydroxyindol acetic acid (5-HIAA) were evaluated in brain regions (cerebellum, brainstem, striatum, cerebral cortex, hypothalamus and hippocampus). The result indicated that the administration of subacute dose of LA (100 mg/kg/day, i.p.) induce a significant decrease in NE, DA, 5-HT and 5-HIAA content in all tested brain regions. Also the obtained data showed significant increase in liver enzymes: serum glutamate oxaloacetate transaminase (GOT), serum glutamate pyruvate transaminase (GPT) and Lactate dehydrogenase (LDH) level in group 2 (positive control). There is an improvement in neurotransmitters content. Also the obtained data showed significant in- crease in liver enzymes of protective (G3) and therapeutics groups (G4, G5 and G6) which received GSE compared with animal group that received lead acetate (G2). This is may be the presence of proanthocyanidins and procyanidins which have antioxidant and free radical scavenging activities. The result suggests that grape seed extract may prevent lead-induced neurotoxicity and hepatotoxicity." @default.
• W2103906403 created "2016-06-24" @default.
• W2103906403 creator A5085649353 @default.
• W2103906403 date "2012-01-01" @default.
• W2103906403 modified "2023-09-30" @default.
• W2103906403 title "Grape Seed Extract (&lt;i&gt;Vitisvinifera&lt;/i&gt;) Alleviate Neurotoxicity and Hepatotoxicity Induced by Lead Acetate in Male Albino Rats" @default.
• W2103906403 cites W1554374902 @default.
• W2103906403 cites W1609018198 @default.
• W2103906403 cites W1684853394 @default.
• W2103906403 cites W1909383564 @default.
• W2103906403 cites W1966438431 @default.
• W2103906403 cites W1972097754 @default.
• W2103906403 cites W1975582550 @default.
• W2103906403 cites W1991039998 @default.
• W2103906403 cites W1993208880 @default.
• W2103906403 cites W1995897250 @default.
• W2103906403 cites W1996669090 @default.
• W2103906403 cites W2007876572 @default.
• W2103906403 cites W2008920058 @default.
• W2103906403 cites W2009670021 @default.
• W2103906403 cites W2013836023 @default.
• W2103906403 cites W2018796723 @default.
• W2103906403 cites W2021025567 @default.
• W2103906403 cites W2027871116 @default.
• W2103906403 cites W2030671355 @default.
• W2103906403 cites W2031565323 @default.
• W2103906403 cites W2033074087 @default.
• W2103906403 cites W2036509452 @default.
• W2103906403 cites W2038021394 @default.
• W2103906403 cites W2038205497 @default.
• W2103906403 cites W2038304850 @default.
• W2103906403 cites W2038464638 @default.
• W2103906403 cites W2047814923 @default.
• W2103906403 cites W2052031543 @default.
• W2103906403 cites W2055031115 @default.
• W2103906403 cites W2065005507 @default.
• W2103906403 cites W2073413777 @default.
• W2103906403 cites W2076092597 @default.
• W2103906403 cites W2082136439 @default.
• W2103906403 cites W2082724832 @default.
• W2103906403 cites W2083107122 @default.
• W2103906403 cites W2092971063 @default.
• W2103906403 cites W2095215507 @default.
• W2103906403 cites W2098275836 @default.
• W2103906403 cites W2105681555 @default.
• W2103906403 cites W2108079568 @default.
• W2103906403 cites W2120876065 @default.
• W2103906403 cites W2142767767 @default.
• W2103906403 cites W2148575198 @default.
• W2103906403 cites W2152288875 @default.
• W2103906403 cites W2152879693 @default.
• W2103906403 cites W2158456700 @default.
• W2103906403 cites W2166511953 @default.
• W2103906403 cites W2170251226 @default.
• W2103906403 cites W4247565892 @default.
• W2103906403 doi "https://doi.org/10.4236/jbbs.2012.22021" @default.
• W2103906403 hasPublicationYear "2012" @default.
• W2103906403 type Work @default.
• W2103906403 sameAs 2103906403 @default.
• W2103906403 citedByCount "18" @default.
• W2103906403 countsByYear W21039064032013 @default.
• W2103906403 countsByYear W21039064032015 @default.
• W2103906403 countsByYear W21039064032016 @default.
• W2103906403 countsByYear W21039064032017 @default.
• W2103906403 countsByYear W21039064032018 @default.
• W2103906403 countsByYear W21039064032019 @default.
• W2103906403 countsByYear W21039064032020 @default.
• W2103906403 countsByYear W21039064032021 @default.
• W2103906403 countsByYear W21039064032022 @default.
• W2103906403 crossrefType "journal-article" @default.
• W2103906403 hasAuthorship W2103906403A5085649353 @default.
• W2103906403 hasBestOaLocation W21039064031 @default.
• W2103906403 hasConcept C126322002 @default.
• W2103906403 hasConcept C134018914 @default.
• W2103906403 hasConcept C170493617 @default.
• W2103906403 hasConcept C185592680 @default.
• W2103906403 hasConcept C187714386 @default.
• W2103906403 hasConcept C2775864247 @default.
• W2103906403 hasConcept C2777397205 @default.
• W2103906403 hasConcept C2778004101 @default.
• W2103906403 hasConcept C2779224224 @default.
• W2103906403 hasConcept C2779491297 @default.
• W2103906403 hasConcept C2780062018 @default.
• W2103906403 hasConcept C2781161787 @default.
• W2103906403 hasConcept C29730261 @default.
• W2103906403 hasConcept C513476851 @default.
• W2103906403 hasConcept C55493867 @default.
• W2103906403 hasConcept C71924100 @default.
• W2103906403 hasConcept C98274493 @default.
• W2103906403 hasConceptScore W2103906403C126322002 @default.
• W2103906403 hasConceptScore W2103906403C134018914 @default.
• W2103906403 hasConceptScore W2103906403C170493617 @default.
• W2103906403 hasConceptScore W2103906403C185592680 @default.
• W2103906403 hasConceptScore W2103906403C187714386 @default.
• W2103906403 hasConceptScore W2103906403C2775864247 @default.
• W2103906403 hasConceptScore W2103906403C2777397205 @default.
• W2103906403 hasConceptScore W2103906403C2778004101 @default.
• W2103906403 hasConceptScore W2103906403C2779224224 @default.

• next