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• W2103923504 abstract "Abstract: The effects of serum, α-1 acid glycoprotein (AAG), serum lipoproteins (SLP) and human serum albumin (HSA) on 3H-(-)-dihydroalprenolol (3H-(-)-DHA) binding and (-)-isoproterenol ((-)-IPR) induced cyclic AMP (cAMP) elevation in human peripheral blood mononuclear leucocytes (MNL) were investigated. The saturable binding of 3H-(-)-DHA was decomposed into two classes of binding sites with maximum binding capacity of approximately 1400 and 30000 sites/cell and with dissociation constants (Kd) of approximately 0.7 and 65 nM. Stimulation of the MNL β-adrenoceptors by (-)-IPR caused a concentration dependent cAMP accumulation (EC50 ∼0.2 μM) with maximum level approximately 250% above basal. For all single leucocyte preparations, 30–35 min. exposure to serum, AAG and SLP increased the number of β-adrenoceptors with 100–200% and the maximal responsiveness to (-)-IPR with 30–90%. The presence of proteins did not change the Kd or the EC50. (-)-Alprenolol inhibited concentration dependently the serum induced increment in (-)-IPR-responsiveness. Serum, AAG and SLP did also increase the number of low affinity binding sites with 25–40% without effect on the Kd. HSA had no consistent effect on β-adrenergic binding or stimulation. The present study shows that serum, AAG and SLP influence the number and function of MNL β-adrenoceptors in vitro." @default.
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• W2103923504 date "2009-03-13" @default.
• W2103923504 modified "2023-09-26" @default.
• W2103923504 title "Effect of Serum, α-1 Acid Glycoprotein, Lipoproteins and Albumin on Human Mononuclear Leucocyte β-Adrenoceptors" @default.
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• W2103923504 doi "https://doi.org/10.1111/j.1600-0773.1986.tb00094.x" @default.
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