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• W2103937369 abstract "Transplantation of vascular endothelial growth factor (VEGF) gene-manipulated mesenchymal stem cells (MSCs) has been proposed as a promising therapy strategy for cardiac repair after myocardium infarction. However, the gene delivery system, including targeted VEGF gene and delivery vehicle, still needs to be optimized. In this study, a novel, hyperbranched poly(amidoamine) (hPAMAM), polymer-based, hypoxia-regulated VEGF 165 plasmid (pHRE-VEGF 165 ) delivery system was constructed for effective, biocompatible and controllable gene expression. The hPAMAM demonstrated high transfection efficiency (38.98 ± 1.95%) with minor cytotoxicity (cell viability = 92.38 ± 1.09%) in primary MSCs under optimal conditions. Under hypoxia, hPAMAM-pHRE-hVEGF 165 -transfected MSCs could over-express hVEGF 165 stably for 14 days, with a peak expression at day 2, which promoted endothelial cell proliferation in vitro. The transplantation of hPAMAM-pHRE-hVEGF 165 gene delivery system-manipulated MSCs could enhance ischemic myocardium VEGF concentration obviously, which improved the graft MSC survival, increased neovascularization, and ultimately preserved cardiac function to a significantly greater degree than untreated MSC transplantation. This work demonstrated that hPAMAM-based pHRE-hVEGF 165 gene delivery combined with MSC transplantation is an economical, feasible and biocompatible strategy for cardiac repair." @default.
• W2103937369 created "2016-06-24" @default.
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• W2103937369 date "2012-06-01" @default.
• W2103937369 modified "2023-09-26" @default.
• W2103937369 title "Novel vascular endothelial growth factor gene delivery system-manipulated mesenchymal stem cells repair infarcted myocardium" @default.
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• W2103937369 doi "https://doi.org/10.1258/ebm.2012.011430" @default.
• W2103937369 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/22728704" @default.
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