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• W2103971830 endingPage "576" @default.
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• W2103971830 abstract "Appropriate differentiation and development of higherorganisms require precisely regulated expression of multiple genes. The primary control for most genes is exertedat the level of transcription. This involves the combinatorial action of tissue-specific and ubiquitous transcriptionfactors acting at regulatory sequences that are proximal(promoters) or distal (enhancers, insulators, silencers,and locus control regions [LCRs]) to a gene. The existence of functionally distinct cis-acting elements indicates that the high degree of regulation involved in coordinated gene expression within a complex organismrequires more intricate circuitry than a simple promotercan provide to turn genes on and off. A critical aspect ofthis circuitry and coordination is the regulation imposedupon genes within a complex nuclear environment..." @default.
• W2103971830 created "2016-06-24" @default.
• W2103971830 creator A5048532228 @default.
• W2103971830 creator A5074080321 @default.
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• W2103971830 date "1998-01-01" @default.
• W2103971830 modified "2023-09-27" @default.
• W2103971830 title "Role of Chromatin Structure and Distal Enhancers in Tissue-specific Transcriptional Regulation In Vitro" @default.
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• W2103971830 doi "https://doi.org/10.1101/sqb.1998.63.569" @default.
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