FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2103976992> ?p ?o ?g. }

• W2103976992 endingPage "2104" @default.
• W2103976992 startingPage "2091" @default.
• W2103976992 abstract "The preferential recognition of certain amino acid sequences from foreign protein antigens by T cells is referred to as T cell epitope immunodominance. To determine the mechanisms underlying this phenomenon, we have studied the correlation between the interaction of a series of synthetic peptides encompassing the entire hen egg-white lysozyme (HEL) sequence with class II molecules of the H-2k haplotype, and T cell responsiveness to these peptides. After HEL priming, three immunodominant T cell epitopes were found: two, included in the HEL sequences 51-61 and 112-129, were recognized in association with I-Ak molecules, and one, included in sequence 1-18, in association with I-Ek molecules. Accordingly, these peptides bound to the appropriate class II molecule, as demonstrated by competition for antigen presentation. Several other HEL peptides, although capable of associating with class II molecules, were not immunodominant. The absence of immunodominance has been shown to arise by three different mechanisms: (a) competition by an immunodominant peptide for presentation in vivo, (b) failure to generate the peptide during antigen processing, and (c) an inherently poor capacity of the T cell repertoire to respond to a particular peptide-MHC complex." @default.
• W2103976992 created "2016-06-24" @default.
• W2103976992 creator A5021850748 @default.
• W2103976992 creator A5036354240 @default.
• W2103976992 creator A5042486585 @default.
• W2103976992 creator A5058458204 @default.
• W2103976992 date "1988-12-01" @default.
• W2103976992 modified "2023-09-24" @default.
• W2103976992 title "Mechanisms influencing the immunodominance of T cell determinants." @default.
• W2103976992 cites W1501936064 @default.
• W2103976992 cites W1650026319 @default.
• W2103976992 cites W1917992476 @default.
• W2103976992 cites W1970930845 @default.
• W2103976992 cites W1974061274 @default.
• W2103976992 cites W1982034991 @default.
• W2103976992 cites W1983733943 @default.
• W2103976992 cites W2005016180 @default.
• W2103976992 cites W2031764905 @default.
• W2103976992 cites W2033583315 @default.
• W2103976992 cites W2036463478 @default.
• W2103976992 cites W2044063726 @default.
• W2103976992 cites W2051189682 @default.
• W2103976992 cites W2063579015 @default.
• W2103976992 cites W2074072194 @default.
• W2103976992 cites W2080757497 @default.
• W2103976992 cites W2082108597 @default.
• W2103976992 cites W2091585240 @default.
• W2103976992 cites W2111441225 @default.
• W2103976992 cites W2125745098 @default.
• W2103976992 cites W2137893932 @default.
• W2103976992 cites W2142414226 @default.
• W2103976992 cites W2149117794 @default.
• W2103976992 cites W2156877588 @default.
• W2103976992 cites W2162097082 @default.
• W2103976992 cites W2267207490 @default.
• W2103976992 cites W2394807882 @default.
• W2103976992 doi "https://doi.org/10.1084/jem.168.6.2091" @default.
• W2103976992 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/2189152" @default.
• W2103976992 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/2462005" @default.
• W2103976992 hasPublicationYear "1988" @default.
• W2103976992 type Work @default.
• W2103976992 sameAs 2103976992 @default.
• W2103976992 citedByCount "225" @default.
• W2103976992 countsByYear W21039769922012 @default.
• W2103976992 countsByYear W21039769922013 @default.
• W2103976992 countsByYear W21039769922015 @default.
• W2103976992 countsByYear W21039769922016 @default.
• W2103976992 countsByYear W21039769922018 @default.
• W2103976992 countsByYear W21039769922019 @default.
• W2103976992 countsByYear W21039769922020 @default.
• W2103976992 countsByYear W21039769922021 @default.
• W2103976992 countsByYear W21039769922023 @default.
• W2103976992 crossrefType "journal-article" @default.
• W2103976992 hasAuthorship W2103976992A5021850748 @default.
• W2103976992 hasAuthorship W2103976992A5036354240 @default.
• W2103976992 hasAuthorship W2103976992A5042486585 @default.
• W2103976992 hasAuthorship W2103976992A5058458204 @default.
• W2103976992 hasBestOaLocation W21039769921 @default.
• W2103976992 hasConcept C100701293 @default.
• W2103976992 hasConcept C104317684 @default.
• W2103976992 hasConcept C108249834 @default.
• W2103976992 hasConcept C147483822 @default.
• W2103976992 hasConcept C167625842 @default.
• W2103976992 hasConcept C170627219 @default.
• W2103976992 hasConcept C195616568 @default.
• W2103976992 hasConcept C203014093 @default.
• W2103976992 hasConcept C207936829 @default.
• W2103976992 hasConcept C2776090121 @default.
• W2103976992 hasConcept C2776525413 @default.
• W2103976992 hasConcept C2778814158 @default.
• W2103976992 hasConcept C2779281246 @default.
• W2103976992 hasConcept C54355233 @default.
• W2103976992 hasConcept C55493867 @default.
• W2103976992 hasConcept C59822182 @default.
• W2103976992 hasConcept C81444415 @default.
• W2103976992 hasConcept C83464605 @default.
• W2103976992 hasConcept C86803240 @default.
• W2103976992 hasConcept C8891405 @default.
• W2103976992 hasConceptScore W2103976992C100701293 @default.
• W2103976992 hasConceptScore W2103976992C104317684 @default.
• W2103976992 hasConceptScore W2103976992C108249834 @default.
• W2103976992 hasConceptScore W2103976992C147483822 @default.
• W2103976992 hasConceptScore W2103976992C167625842 @default.
• W2103976992 hasConceptScore W2103976992C170627219 @default.
• W2103976992 hasConceptScore W2103976992C195616568 @default.
• W2103976992 hasConceptScore W2103976992C203014093 @default.
• W2103976992 hasConceptScore W2103976992C207936829 @default.
• W2103976992 hasConceptScore W2103976992C2776090121 @default.
• W2103976992 hasConceptScore W2103976992C2776525413 @default.
• W2103976992 hasConceptScore W2103976992C2778814158 @default.
• W2103976992 hasConceptScore W2103976992C2779281246 @default.
• W2103976992 hasConceptScore W2103976992C54355233 @default.
• W2103976992 hasConceptScore W2103976992C55493867 @default.
• W2103976992 hasConceptScore W2103976992C59822182 @default.
• W2103976992 hasConceptScore W2103976992C81444415 @default.
• W2103976992 hasConceptScore W2103976992C83464605 @default.
• W2103976992 hasConceptScore W2103976992C86803240 @default.
• W2103976992 hasConceptScore W2103976992C8891405 @default.

• next