FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2103977809> ?p ?o ?g. }

• W2103977809 endingPage "881" @default.
• W2103977809 startingPage "870" @default.
• W2103977809 abstract "H(2)O(2) induces apoptosis in variety of cells; however, the sensitivities of testicular germ cells to H(2)O(2) are not known. In the present study, H(2)O(2), at concentrations in the range 1-10 microM, was found to induce apoptosis in testicular germ cells in vitro. Following 1 h of treatment with 10 microM H(2)O(2), a 10-fold rise in the percentage of apoptotic cells was observed. Induction of germ cell apoptosis was directly associated with a significant (P < 0.01) increase in lipid peroxidation and a concomitant decrease in superoxide dismutase and catalase activity. Examination of apoptotic signalling pathways revealed an increased expression of extrinsic (Fas, FasL and caspase-8) and intrinsic (Bid, Bak, Bad, Bax and caspase-9) markers, as well as p53, along with a simultaneous decrease in the Bcl-2 protein at the highest concentration of H(2)O(2) exposure. Both, c-jun N-terminal kinase and p38 phosphorylated forms were found to be up-regulated. Interestingly, up-regulation of the nuclear transcription factor kappa B was also observed. The respective transcripts for many of the above proteins followed an identical trend. Caspase-3 activity was also estimated to be 30-fold higher. Taken together, the above data indicate that testicular germ cells are prone to apoptosis at very low concentrations of H(2)O(2), the mechanism of which involves extrinsic and intrinsic as well other regulatory pathways." @default.
• W2103977809 created "2016-06-24" @default.
• W2103977809 creator A5021869528 @default.
• W2103977809 creator A5027289068 @default.
• W2103977809 creator A5040605283 @default.
• W2103977809 creator A5062426257 @default.
• W2103977809 creator A5091643482 @default.
• W2103977809 date "2009-01-07" @default.
• W2103977809 modified "2023-09-27" @default.
• W2103977809 title "Pathways involved in testicular germ cell apoptosis induced by H2O2in vitro" @default.
• W2103977809 cites W1535454769 @default.
• W2103977809 cites W1581414347 @default.
• W2103977809 cites W1745634660 @default.
• W2103977809 cites W191793640 @default.
• W2103977809 cites W1964597297 @default.
• W2103977809 cites W1964815632 @default.
• W2103977809 cites W1983310681 @default.
• W2103977809 cites W1987195618 @default.
• W2103977809 cites W1989693531 @default.
• W2103977809 cites W1993735204 @default.
• W2103977809 cites W1994388349 @default.
• W2103977809 cites W1995777493 @default.
• W2103977809 cites W1997208169 @default.
• W2103977809 cites W2003579383 @default.
• W2103977809 cites W2004062071 @default.
• W2103977809 cites W2011342890 @default.
• W2103977809 cites W2022127636 @default.
• W2103977809 cites W2022615484 @default.
• W2103977809 cites W2023568379 @default.
• W2103977809 cites W2024468216 @default.
• W2103977809 cites W2027704751 @default.
• W2103977809 cites W2028284622 @default.
• W2103977809 cites W2041466047 @default.
• W2103977809 cites W2043854655 @default.
• W2103977809 cites W2053076131 @default.
• W2103977809 cites W2067549655 @default.
• W2103977809 cites W2074212982 @default.
• W2103977809 cites W2076832038 @default.
• W2103977809 cites W2082237426 @default.
• W2103977809 cites W2087877138 @default.
• W2103977809 cites W2089521856 @default.
• W2103977809 cites W2100125917 @default.
• W2103977809 cites W2108465682 @default.
• W2103977809 cites W2111228147 @default.
• W2103977809 cites W2120145505 @default.
• W2103977809 cites W2125369238 @default.
• W2103977809 cites W2126327941 @default.
• W2103977809 cites W2130087376 @default.
• W2103977809 cites W2130614519 @default.
• W2103977809 cites W2144586856 @default.
• W2103977809 cites W2170597525 @default.
• W2103977809 cites W2314469790 @default.
• W2103977809 cites W4234963138 @default.
• W2103977809 cites W4238724219 @default.
• W2103977809 doi "https://doi.org/10.1111/j.1742-4658.2008.06831.x" @default.
• W2103977809 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/19143845" @default.
• W2103977809 hasPublicationYear "2009" @default.
• W2103977809 type Work @default.
• W2103977809 sameAs 2103977809 @default.
• W2103977809 citedByCount "93" @default.
• W2103977809 countsByYear W21039778092012 @default.
• W2103977809 countsByYear W21039778092013 @default.
• W2103977809 countsByYear W21039778092014 @default.
• W2103977809 countsByYear W21039778092015 @default.
• W2103977809 countsByYear W21039778092016 @default.
• W2103977809 countsByYear W21039778092017 @default.
• W2103977809 countsByYear W21039778092018 @default.
• W2103977809 countsByYear W21039778092019 @default.
• W2103977809 countsByYear W21039778092020 @default.
• W2103977809 countsByYear W21039778092021 @default.
• W2103977809 countsByYear W21039778092022 @default.
• W2103977809 countsByYear W21039778092023 @default.
• W2103977809 crossrefType "journal-article" @default.
• W2103977809 hasAuthorship W2103977809A5021869528 @default.
• W2103977809 hasAuthorship W2103977809A5027289068 @default.
• W2103977809 hasAuthorship W2103977809A5040605283 @default.
• W2103977809 hasAuthorship W2103977809A5062426257 @default.
• W2103977809 hasAuthorship W2103977809A5091643482 @default.
• W2103977809 hasConcept C104317684 @default.
• W2103977809 hasConcept C12519072 @default.
• W2103977809 hasConcept C153911025 @default.
• W2103977809 hasConcept C184235292 @default.
• W2103977809 hasConcept C185592680 @default.
• W2103977809 hasConcept C190283241 @default.
• W2103977809 hasConcept C202751555 @default.
• W2103977809 hasConcept C2775838275 @default.
• W2103977809 hasConcept C2776151105 @default.
• W2103977809 hasConcept C2779122487 @default.
• W2103977809 hasConcept C31573885 @default.
• W2103977809 hasConcept C51551487 @default.
• W2103977809 hasConcept C55493867 @default.
• W2103977809 hasConcept C66008609 @default.
• W2103977809 hasConcept C86803240 @default.
• W2103977809 hasConcept C95444343 @default.
• W2103977809 hasConcept C97029542 @default.
• W2103977809 hasConceptScore W2103977809C104317684 @default.
• W2103977809 hasConceptScore W2103977809C12519072 @default.
• W2103977809 hasConceptScore W2103977809C153911025 @default.

• next