FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2103979596> ?p ?o ?g. }

• W2103979596 endingPage "707" @default.
• W2103979596 startingPage "696" @default.
• W2103979596 abstract "The structure of the SigB-dependent general stress regulon of Bacillus subtilis has previously been characterized by proteomics approaches as well as DNA array-based expression studies. However, comparing the SigB targets published in three previous major transcriptional profiling studies it is obvious that although each of them identified well above 100 target genes, only 67 were identified in all three studies. These substantial differences can likely be attributed to the different strains, growth conditions, microarray platforms and experimental setups used in the studies. In order to gain a better understanding of the structure of this important regulon, a targeted DNA microarray analysis covering most of the known SigB-inducing conditions was performed, and the changes in expression kinetics of 252 potential members of the SigB regulon and appropriate control genes were recorded. Transcriptional data for the B. subtilis wild-type strain 168 and its isogenic sigB mutant BSM29 were analysed using random forest, a machine learning algorithm, by incorporating the knowledge from previous studies. This analysis revealed a strictly SigB-dependent expression pattern for 166 genes following ethanol, butanol, osmotic and oxidative stress, low-temperature growth and heat shock, as well as limitation of oxygen or glucose. Kinetic analysis of the data for the wild-type strain identified 30 additional members of the SigB regulon, which were also subject to control by additional transcriptional regulators, thus displaying atypical SigB-independent induction patterns in the mutant strain under some of the conditions tested. For 19 of these 30 SigB regulon members, published reports support control by secondary regulators along with SigB. Thus, this microarray-based study assigns a total of 196 genes to the SigB-dependent general stress regulon of B. subtilis." @default.
• W2103979596 created "2016-06-24" @default.
• W2103979596 creator A5015476234 @default.
• W2103979596 creator A5020912770 @default.
• W2103979596 creator A5022720360 @default.
• W2103979596 creator A5024324359 @default.
• W2103979596 creator A5049855503 @default.
• W2103979596 creator A5076037735 @default.
• W2103979596 creator A5082748007 @default.
• W2103979596 creator A5085667735 @default.
• W2103979596 date "2012-03-01" @default.
• W2103979596 modified "2023-10-12" @default.
• W2103979596 title "Defining the structure of the general stress regulon of Bacillus subtilis using targeted microarray analysis and random forest classification" @default.
• W2103979596 cites W1480690554 @default.
• W2103979596 cites W1488068148 @default.
• W2103979596 cites W1494526651 @default.
• W2103979596 cites W1500152947 @default.
• W2103979596 cites W1504371068 @default.
• W2103979596 cites W1536724064 @default.
• W2103979596 cites W1549068883 @default.
• W2103979596 cites W1584053032 @default.
• W2103979596 cites W1606738601 @default.
• W2103979596 cites W1823383792 @default.
• W2103979596 cites W1838792009 @default.
• W2103979596 cites W1875061881 @default.
• W2103979596 cites W1922727446 @default.
• W2103979596 cites W1966717858 @default.
• W2103979596 cites W1972452577 @default.
• W2103979596 cites W1975339453 @default.
• W2103979596 cites W1979431512 @default.
• W2103979596 cites W1981473578 @default.
• W2103979596 cites W1982327567 @default.
• W2103979596 cites W1985653246 @default.
• W2103979596 cites W1999240063 @default.
• W2103979596 cites W2007839457 @default.
• W2103979596 cites W2021381880 @default.
• W2103979596 cites W2029480898 @default.
• W2103979596 cites W2034411310 @default.
• W2103979596 cites W2035564383 @default.
• W2103979596 cites W2047679564 @default.
• W2103979596 cites W2050003572 @default.
• W2103979596 cites W2050951379 @default.
• W2103979596 cites W2058415888 @default.
• W2103979596 cites W205951511 @default.
• W2103979596 cites W2070856482 @default.
• W2103979596 cites W2076779583 @default.
• W2103979596 cites W2085319055 @default.
• W2103979596 cites W2096072638 @default.
• W2103979596 cites W2096859475 @default.
• W2103979596 cites W2099083388 @default.
• W2103979596 cites W2099428890 @default.
• W2103979596 cites W2100882223 @default.
• W2103979596 cites W2100975834 @default.
• W2103979596 cites W2101292724 @default.
• W2103979596 cites W2102624858 @default.
• W2103979596 cites W2109835041 @default.
• W2103979596 cites W2110169409 @default.
• W2103979596 cites W2110946298 @default.
• W2103979596 cites W2114755250 @default.
• W2103979596 cites W2124181495 @default.
• W2103979596 cites W2129606026 @default.
• W2103979596 cites W2130412668 @default.
• W2103979596 cites W2134331533 @default.
• W2103979596 cites W2136911633 @default.
• W2103979596 cites W2139578793 @default.
• W2103979596 cites W2142363993 @default.
• W2103979596 cites W2144190655 @default.
• W2103979596 cites W2144760185 @default.
• W2103979596 cites W2147571606 @default.
• W2103979596 cites W2166807076 @default.
• W2103979596 cites W2167468292 @default.
• W2103979596 cites W2168225803 @default.
• W2103979596 cites W2171100383 @default.
• W2103979596 cites W2911964244 @default.
• W2103979596 cites W382652726 @default.
• W2103979596 cites W4253110992 @default.
• W2103979596 doi "https://doi.org/10.1099/mic.0.055434-0" @default.
• W2103979596 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/22174379" @default.
• W2103979596 hasPublicationYear "2012" @default.
• W2103979596 type Work @default.
• W2103979596 sameAs 2103979596 @default.
• W2103979596 citedByCount "59" @default.
• W2103979596 countsByYear W21039795962012 @default.
• W2103979596 countsByYear W21039795962013 @default.
• W2103979596 countsByYear W21039795962014 @default.
• W2103979596 countsByYear W21039795962015 @default.
• W2103979596 countsByYear W21039795962016 @default.
• W2103979596 countsByYear W21039795962017 @default.
• W2103979596 countsByYear W21039795962018 @default.
• W2103979596 countsByYear W21039795962019 @default.
• W2103979596 countsByYear W21039795962020 @default.
• W2103979596 countsByYear W21039795962021 @default.
• W2103979596 countsByYear W21039795962022 @default.
• W2103979596 countsByYear W21039795962023 @default.
• W2103979596 crossrefType "journal-article" @default.
• W2103979596 hasAuthorship W2103979596A5015476234 @default.
• W2103979596 hasAuthorship W2103979596A5020912770 @default.
• W2103979596 hasAuthorship W2103979596A5022720360 @default.

• next