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- W2103990022 abstract "Using the pulse radiolysis technique, we have demonstrated that bleomycin-Fe(III) is stoichiometrically reduced by CO2- to bleomycin-Fe(II) with a rate of (1.9 +/- 0.2) x 10(8) M-1s-1. In the presence of calf thymus DNA, the reduction proceeds through free bleomycin-Fe(III) and the binding constant of bleomycin-Fe(III) to DNA has been determined to be (3.8 +/- 0.5) x 10(4) M-1. It has also been demonstrated that in the absence of DNA O2- reacts with bleomycin-Fe(III) to yield bleomycin-Fe(II)O2, which is in rapid equilibrium with molecular oxygen, and decomposes at room temperature with a rate of (700 +/- 200) s-1. The resulting product of the decomposition reaction is Fe(III) which is bound to a modified bleomycin molecule. We have demonstrated that during the reaction of bleomycin-Fe(II) with O2, modification or self-destruction of the drug occurs, while in the presence of DNA no destruction occurs, possibly because the reaction causes degradation of DNA." @default.
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- W2103990022 date "1987-01-01" @default.
- W2103990022 modified "2023-09-25" @default.
- W2103990022 title "Oxidation-Reduction Reactions of Iron Bleomycin in the Absence and Presence of DNA" @default.
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- W2103990022 doi "https://doi.org/10.3109/10715768709065290" @default.
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