FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2103990238> ?p ?o ?g. }

• W2103990238 endingPage "1917" @default.
• W2103990238 startingPage "1907" @default.
• W2103990238 abstract "Small noncoding RNAs (sRNAs) regulate the response of bacteria to environmental stress in conjunction with the Sm-like RNA binding protein Hfq. DsrA sRNA stimulates translation of the RpoS stress response factor in Escherichia coli by base-pairing with the 5′ leader of the rpoS mRNA and opening a stem–loop that represses translation initiation. We report that rpoS leader sequences upstream of this stem–loop greatly increase the sensitivity of rpoS mRNA to Hfq and DsrA. Native gel mobility shift assays show that Hfq increases the rate of DsrA binding to the full 576 nt rpoS leader as much as 50-fold. By contrast, base-pairing with a 138-nt RNA containing just the repressor stem–loop is accelerated only twofold. Deletion and mutagenesis experiments showed that sensitivity to Hfq requires an upstream AAYAA sequence. Leaders long enough to contain this sequence bind Hfq tightly and form stable ternary complexes with Hfq and DsrA. A model is proposed in which Hfq recruits DsrA to the rpoS mRNA by binding both RNAs, releasing the self-repressing structure in the mRNA. Once base-pairing between DsrA and rpoS mRNA is established, interactions between Hfq and the mRNA may stabilize the RNA complex by removing Hfq from the sRNA." @default.
• W2103990238 created "2016-06-24" @default.
• W2103990238 creator A5004911684 @default.
• W2103990238 creator A5078281937 @default.
• W2103990238 date "2008-07-24" @default.
• W2103990238 modified "2023-10-16" @default.
• W2103990238 title "The <i>rpoS</i> mRNA leader recruits Hfq to facilitate annealing with DsrA sRNA" @default.
• W2103990238 cites W1515655426 @default.
• W2103990238 cites W1571614574 @default.
• W2103990238 cites W1571932130 @default.
• W2103990238 cites W1577561851 @default.
• W2103990238 cites W1590552741 @default.
• W2103990238 cites W1845702142 @default.
• W2103990238 cites W1934866768 @default.
• W2103990238 cites W1939409359 @default.
• W2103990238 cites W1969394919 @default.
• W2103990238 cites W1971739813 @default.
• W2103990238 cites W1972312133 @default.
• W2103990238 cites W1972533328 @default.
• W2103990238 cites W1975228919 @default.
• W2103990238 cites W1978797503 @default.
• W2103990238 cites W1983373334 @default.
• W2103990238 cites W1986385237 @default.
• W2103990238 cites W1997374378 @default.
• W2103990238 cites W1998348634 @default.
• W2103990238 cites W2004945910 @default.
• W2103990238 cites W2013631801 @default.
• W2103990238 cites W2028102516 @default.
• W2103990238 cites W2030976361 @default.
• W2103990238 cites W2031281479 @default.
• W2103990238 cites W2032664212 @default.
• W2103990238 cites W2034857418 @default.
• W2103990238 cites W2053138947 @default.
• W2103990238 cites W2060510537 @default.
• W2103990238 cites W2072422539 @default.
• W2103990238 cites W2072656934 @default.
• W2103990238 cites W2093748687 @default.
• W2103990238 cites W2099940763 @default.
• W2103990238 cites W2102361423 @default.
• W2103990238 cites W2105495135 @default.
• W2103990238 cites W2105503921 @default.
• W2103990238 cites W2108820240 @default.
• W2103990238 cites W2113032385 @default.
• W2103990238 cites W2118400513 @default.
• W2103990238 cites W2120974004 @default.
• W2103990238 cites W2130502159 @default.
• W2103990238 cites W2136659582 @default.
• W2103990238 cites W2142136966 @default.
• W2103990238 cites W2152499578 @default.
• W2103990238 cites W2158408911 @default.
• W2103990238 cites W2159850373 @default.
• W2103990238 cites W2165961683 @default.
• W2103990238 cites W2171084339 @default.
• W2103990238 cites W2616766631 @default.
• W2103990238 doi "https://doi.org/10.1261/rna.1110608" @default.
• W2103990238 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/2525945" @default.
• W2103990238 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/18658123" @default.
• W2103990238 hasPublicationYear "2008" @default.
• W2103990238 type Work @default.
• W2103990238 sameAs 2103990238 @default.
• W2103990238 citedByCount "191" @default.
• W2103990238 countsByYear W21039902382012 @default.
• W2103990238 countsByYear W21039902382013 @default.
• W2103990238 countsByYear W21039902382014 @default.
• W2103990238 countsByYear W21039902382015 @default.
• W2103990238 countsByYear W21039902382016 @default.
• W2103990238 countsByYear W21039902382017 @default.
• W2103990238 countsByYear W21039902382018 @default.
• W2103990238 countsByYear W21039902382019 @default.
• W2103990238 countsByYear W21039902382020 @default.
• W2103990238 countsByYear W21039902382021 @default.
• W2103990238 countsByYear W21039902382022 @default.
• W2103990238 countsByYear W21039902382023 @default.
• W2103990238 crossrefType "journal-article" @default.
• W2103990238 hasAuthorship W2103990238A5004911684 @default.
• W2103990238 hasAuthorship W2103990238A5078281937 @default.
• W2103990238 hasBestOaLocation W21039902381 @default.
• W2103990238 hasConcept C101762097 @default.
• W2103990238 hasConcept C104317684 @default.
• W2103990238 hasConcept C105580179 @default.
• W2103990238 hasConcept C114847915 @default.
• W2103990238 hasConcept C143141573 @default.
• W2103990238 hasConcept C147789679 @default.
• W2103990238 hasConcept C149364088 @default.
• W2103990238 hasConcept C150194340 @default.
• W2103990238 hasConcept C153911025 @default.
• W2103990238 hasConcept C153957851 @default.
• W2103990238 hasConcept C176990463 @default.
• W2103990238 hasConcept C185581394 @default.
• W2103990238 hasConcept C185592680 @default.
• W2103990238 hasConcept C194993378 @default.
• W2103990238 hasConcept C2777712861 @default.
• W2103990238 hasConcept C41282012 @default.
• W2103990238 hasConcept C4718897 @default.
• W2103990238 hasConcept C54355233 @default.
• W2103990238 hasConcept C67705224 @default.
• W2103990238 hasConcept C86803240 @default.
• W2103990238 hasConcept C95444343 @default.

• next