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- W2103993062 abstract "Objectives: To document technical and clinical success, and complications associated with use of the WallFlex™ Duodenal Stent (Boston Scientific Corp, Natick, USA) for the palliative management of malignant gastro-duodenal obstruction per standard of practice in a large international multi-centric experience. Stent performance is documented in the largest prospective series conducted to date. Methods: A web-based registry is conducted at 12 endoscopy centers in 10 countries. Follow-up to 9 months is ongoing. An interim analysis is presented. Results: 202 patients (49% male, mean age 70) were enrolled. Most common causes of the stricture were pancreatic cancer (51%), gastric cancer (18%), and duodenal cancer (10%). Stent length was 9 cm (53%), 6 cm (38%), or 12 cm (9%). Technical success was achieved in 96% (193/202). Gastric Outlet Obstruction (GOO) improved from 14% of patients at Baseline tolerating soft solids or low residue/normal diet to 84% at 15 days, 86% at 30 days, 81% at 90 days, and 79% at 180 days. At 90 days post stent placement compared to Baseline, symptoms of post-prandial epigastric tenderness, nausea and vomiting improved in 50%, 55% and 69% of patients respectively and did not worsen in 95% for all three symptoms. The most significant complications to date include stent migration (3%), stent fracture (0.5%), perforation (0.5%), cholangitis (1%), pancreatitis (0.5%), and GOO due to tumor ingrowth (10%), tumor overgrowth (3%) or food impaction (2%). Retreatment occurred in 19 patients (13%); 16/19 received another self-expanding metal stent. To date 59% (119/202) patients died, none due to stent or stenting related complications. Conclusion: Preliminary results from this International Registry related to the WallFlex™ Duodenal Stent, confirm the effectiveness of the endoscopic treatment of GOO with SEMS with acceptable complication profile. Endoscopic re-treatment of malfunctioning (ingrowth/overgrowth) or migrated SEMS is possible." @default.
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- W2103993062 date "2009-04-01" @default.
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- W2103993062 title "Treatment of Malignant Gastro-Duodenal Obstruction Using a Nitinol Self Expanding Metal Stent - An International Prospective Multicenter Experience" @default.
- W2103993062 doi "https://doi.org/10.1016/j.gie.2009.03.653" @default.
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