Matches in SemOpenAlex for { <https://semopenalex.org/work/W2103995443> ?p ?o ?g. }
Showing items 1 to 96 of
96
with 100 items per page.
- W2103995443 endingPage "1584" @default.
- W2103995443 startingPage "1579" @default.
- W2103995443 abstract "Desmin, an intermediate filament, has a key role in the integrity of myocytes, and its absence induces cardiomyopathies. Mice lacking desmin (Des-/- group) exhibit microvascular dysfunction leading to smooth muscle hyporeactivity. We investigated the effect of the absence of desmin in mice (Des-/- mice versus Des+/+ mice) on the adaptation of mesenteric arteries to changes in blood flow.With the use of selective ligations of second-order mesenteric arteries, blood flow was either diminished (low flow [LF]) or elevated (high flow [HF]); respective LF to HF values were 136+/-18 to 206+/-29 microL/min for Des+/+ mice and 119+/-14 to 189+/-24 microL/min for Des-/-mice in daughter arteries. Two weeks after ligation, arteries were mounted in an arteriograph, allowing the measurement of diameter under controlled conditions of pressure and flow. In HF arteries, diameter changes in response to increases in pressure were higher in Des-/- mice than in Des+/+ mice. Conversely, in LF arteries, diameter was lower in Des-/- mice. Flow-dependent dilation was higher in HF arteries and lower in LF arteries than in control arteries. This adaptation was lower in Des-/- mice than in Des+/+ mice (11.6+/-3.1% versus 25.5+/-4.8% dilation, respectively). Endothelial NO synthase expression increased in HF arteries in both strains.These findings provide a demonstration of the role of the intermediate filament desmin in microvascular remodeling. This dysfunction might take place in desmin-related myopathies." @default.
- W2103995443 created "2016-06-24" @default.
- W2103995443 creator A5026377797 @default.
- W2103995443 creator A5039871385 @default.
- W2103995443 creator A5052226015 @default.
- W2103995443 creator A5074641158 @default.
- W2103995443 creator A5074893139 @default.
- W2103995443 date "2002-10-01" @default.
- W2103995443 modified "2023-10-11" @default.
- W2103995443 title "Excessive Microvascular Adaptation to Changes in Blood Flow in Mice Lacking Gene Encoding for Desmin" @default.
- W2103995443 cites W1569974693 @default.
- W2103995443 cites W1967008467 @default.
- W2103995443 cites W2007699535 @default.
- W2103995443 cites W2011299866 @default.
- W2103995443 cites W2023846794 @default.
- W2103995443 cites W2035771990 @default.
- W2103995443 cites W2045075125 @default.
- W2103995443 cites W2087227391 @default.
- W2103995443 cites W2087905663 @default.
- W2103995443 cites W2101722224 @default.
- W2103995443 cites W2102470080 @default.
- W2103995443 cites W2130851152 @default.
- W2103995443 cites W2157059052 @default.
- W2103995443 cites W2341372857 @default.
- W2103995443 cites W4242137284 @default.
- W2103995443 cites W4376595365 @default.
- W2103995443 doi "https://doi.org/10.1161/01.atv.0000032652.24932.1a" @default.
- W2103995443 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/12377733" @default.
- W2103995443 hasPublicationYear "2002" @default.
- W2103995443 type Work @default.
- W2103995443 sameAs 2103995443 @default.
- W2103995443 citedByCount "39" @default.
- W2103995443 countsByYear W21039954432012 @default.
- W2103995443 countsByYear W21039954432013 @default.
- W2103995443 countsByYear W21039954432014 @default.
- W2103995443 countsByYear W21039954432015 @default.
- W2103995443 countsByYear W21039954432016 @default.
- W2103995443 countsByYear W21039954432019 @default.
- W2103995443 countsByYear W21039954432020 @default.
- W2103995443 countsByYear W21039954432021 @default.
- W2103995443 countsByYear W21039954432022 @default.
- W2103995443 crossrefType "journal-article" @default.
- W2103995443 hasAuthorship W2103995443A5026377797 @default.
- W2103995443 hasAuthorship W2103995443A5039871385 @default.
- W2103995443 hasAuthorship W2103995443A5052226015 @default.
- W2103995443 hasAuthorship W2103995443A5074641158 @default.
- W2103995443 hasAuthorship W2103995443A5074893139 @default.
- W2103995443 hasBestOaLocation W21039954431 @default.
- W2103995443 hasConcept C105702510 @default.
- W2103995443 hasConcept C126322002 @default.
- W2103995443 hasConcept C134018914 @default.
- W2103995443 hasConcept C147447768 @default.
- W2103995443 hasConcept C158846371 @default.
- W2103995443 hasConcept C179437574 @default.
- W2103995443 hasConcept C185592680 @default.
- W2103995443 hasConcept C204232928 @default.
- W2103995443 hasConcept C2776820930 @default.
- W2103995443 hasConcept C2779072444 @default.
- W2103995443 hasConcept C2780771799 @default.
- W2103995443 hasConcept C71924100 @default.
- W2103995443 hasConcept C86803240 @default.
- W2103995443 hasConceptScore W2103995443C105702510 @default.
- W2103995443 hasConceptScore W2103995443C126322002 @default.
- W2103995443 hasConceptScore W2103995443C134018914 @default.
- W2103995443 hasConceptScore W2103995443C147447768 @default.
- W2103995443 hasConceptScore W2103995443C158846371 @default.
- W2103995443 hasConceptScore W2103995443C179437574 @default.
- W2103995443 hasConceptScore W2103995443C185592680 @default.
- W2103995443 hasConceptScore W2103995443C204232928 @default.
- W2103995443 hasConceptScore W2103995443C2776820930 @default.
- W2103995443 hasConceptScore W2103995443C2779072444 @default.
- W2103995443 hasConceptScore W2103995443C2780771799 @default.
- W2103995443 hasConceptScore W2103995443C71924100 @default.
- W2103995443 hasConceptScore W2103995443C86803240 @default.
- W2103995443 hasIssue "10" @default.
- W2103995443 hasLocation W21039954431 @default.
- W2103995443 hasLocation W21039954432 @default.
- W2103995443 hasOpenAccess W2103995443 @default.
- W2103995443 hasPrimaryLocation W21039954431 @default.
- W2103995443 hasRelatedWork W1992542653 @default.
- W2103995443 hasRelatedWork W2021893861 @default.
- W2103995443 hasRelatedWork W2066640119 @default.
- W2103995443 hasRelatedWork W2143972452 @default.
- W2103995443 hasRelatedWork W2369941816 @default.
- W2103995443 hasRelatedWork W2969855425 @default.
- W2103995443 hasRelatedWork W3181079444 @default.
- W2103995443 hasRelatedWork W1906685812 @default.
- W2103995443 hasRelatedWork W1968953447 @default.
- W2103995443 hasRelatedWork W2125009908 @default.
- W2103995443 hasVolume "22" @default.
- W2103995443 isParatext "false" @default.
- W2103995443 isRetracted "false" @default.
- W2103995443 magId "2103995443" @default.
- W2103995443 workType "article" @default.