Matches in SemOpenAlex for { <https://semopenalex.org/work/W2103998436> ?p ?o ?g. }
- W2103998436 abstract "Aerosolization of imipenem/cilastatin was compared with continuous intravenous infusions of the antibiotic for pharmacokinetic/pharmacodynamic analysis. The concentrations of imipenim/cilastatin in bronchoalveolar lavage fluids (BAL) obtained from rats exposed to the aerosolized antibiotic were significantly greater than the concentrations in BAL in the rats that had received intravenous infusions of imipenem/cilastatin. The two methods of antibiotic delivery were compared for their effects on bacterial-induced lung injury in rats that had Pseudomonas aeruginosa instilled into their airspaces. The aerosolization of antibiotic was associated with significantly decreased bacterial-induced lung injury. The high concentrations of antibiotic in the airspaces secondary to aerosolization appears to kill bacteria more quickly and preserve lung epithelial and endothelial integrity better than systemic delivery of the same antibiotic." @default.
- W2103998436 created "2016-06-24" @default.
- W2103998436 creator A5009362855 @default.
- W2103998436 creator A5010756643 @default.
- W2103998436 creator A5019471778 @default.
- W2103998436 creator A5036184304 @default.
- W2103998436 creator A5059872950 @default.
- W2103998436 creator A5061897453 @default.
- W2103998436 creator A5067982688 @default.
- W2103998436 creator A5087825657 @default.
- W2103998436 date "1996-11-01" @default.
- W2103998436 modified "2023-09-28" @default.
- W2103998436 title "Aerosolization of imipenem/cilastatin prevents pseudomonas-induced acute lung injury" @default.
- W2103998436 cites W1962188645 @default.
- W2103998436 cites W1969078762 @default.
- W2103998436 cites W1995459103 @default.
- W2103998436 cites W2009061784 @default.
- W2103998436 cites W2035161395 @default.
- W2103998436 cites W2035828859 @default.
- W2103998436 cites W2043457391 @default.
- W2103998436 cites W2059076600 @default.
- W2103998436 cites W2059821482 @default.
- W2103998436 cites W2068939784 @default.
- W2103998436 cites W2074012063 @default.
- W2103998436 cites W2085033676 @default.
- W2103998436 cites W2228337857 @default.
- W2103998436 cites W2338387209 @default.
- W2103998436 cites W2413515818 @default.
- W2103998436 cites W2419317257 @default.
- W2103998436 cites W2468949329 @default.
- W2103998436 cites W264977850 @default.
- W2103998436 doi "https://doi.org/10.1093/jac/38.5.809" @default.
- W2103998436 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/8961050" @default.
- W2103998436 hasPublicationYear "1996" @default.
- W2103998436 type Work @default.
- W2103998436 sameAs 2103998436 @default.
- W2103998436 citedByCount "8" @default.
- W2103998436 countsByYear W21039984362016 @default.
- W2103998436 crossrefType "journal-article" @default.
- W2103998436 hasAuthorship W2103998436A5009362855 @default.
- W2103998436 hasAuthorship W2103998436A5010756643 @default.
- W2103998436 hasAuthorship W2103998436A5019471778 @default.
- W2103998436 hasAuthorship W2103998436A5036184304 @default.
- W2103998436 hasAuthorship W2103998436A5059872950 @default.
- W2103998436 hasAuthorship W2103998436A5061897453 @default.
- W2103998436 hasAuthorship W2103998436A5067982688 @default.
- W2103998436 hasAuthorship W2103998436A5087825657 @default.
- W2103998436 hasBestOaLocation W21039984361 @default.
- W2103998436 hasConcept C112705442 @default.
- W2103998436 hasConcept C126322002 @default.
- W2103998436 hasConcept C2776954882 @default.
- W2103998436 hasConcept C2777437143 @default.
- W2103998436 hasConcept C2777637488 @default.
- W2103998436 hasConcept C2777714996 @default.
- W2103998436 hasConcept C2777961210 @default.
- W2103998436 hasConcept C2779631663 @default.
- W2103998436 hasConcept C2781255259 @default.
- W2103998436 hasConcept C42219234 @default.
- W2103998436 hasConcept C501593827 @default.
- W2103998436 hasConcept C523546767 @default.
- W2103998436 hasConcept C54355233 @default.
- W2103998436 hasConcept C71924100 @default.
- W2103998436 hasConcept C82085835 @default.
- W2103998436 hasConcept C86803240 @default.
- W2103998436 hasConcept C89423630 @default.
- W2103998436 hasConcept C94665300 @default.
- W2103998436 hasConcept C98274493 @default.
- W2103998436 hasConceptScore W2103998436C112705442 @default.
- W2103998436 hasConceptScore W2103998436C126322002 @default.
- W2103998436 hasConceptScore W2103998436C2776954882 @default.
- W2103998436 hasConceptScore W2103998436C2777437143 @default.
- W2103998436 hasConceptScore W2103998436C2777637488 @default.
- W2103998436 hasConceptScore W2103998436C2777714996 @default.
- W2103998436 hasConceptScore W2103998436C2777961210 @default.
- W2103998436 hasConceptScore W2103998436C2779631663 @default.
- W2103998436 hasConceptScore W2103998436C2781255259 @default.
- W2103998436 hasConceptScore W2103998436C42219234 @default.
- W2103998436 hasConceptScore W2103998436C501593827 @default.
- W2103998436 hasConceptScore W2103998436C523546767 @default.
- W2103998436 hasConceptScore W2103998436C54355233 @default.
- W2103998436 hasConceptScore W2103998436C71924100 @default.
- W2103998436 hasConceptScore W2103998436C82085835 @default.
- W2103998436 hasConceptScore W2103998436C86803240 @default.
- W2103998436 hasConceptScore W2103998436C89423630 @default.
- W2103998436 hasConceptScore W2103998436C94665300 @default.
- W2103998436 hasConceptScore W2103998436C98274493 @default.
- W2103998436 hasLocation W21039984361 @default.
- W2103998436 hasLocation W21039984362 @default.
- W2103998436 hasOpenAccess W2103998436 @default.
- W2103998436 hasPrimaryLocation W21039984361 @default.
- W2103998436 hasRelatedWork W1998245452 @default.
- W2103998436 hasRelatedWork W2005763312 @default.
- W2103998436 hasRelatedWork W2041225384 @default.
- W2103998436 hasRelatedWork W2044676975 @default.
- W2103998436 hasRelatedWork W2103998436 @default.
- W2103998436 hasRelatedWork W2121122608 @default.
- W2103998436 hasRelatedWork W2347009769 @default.
- W2103998436 hasRelatedWork W2354620513 @default.
- W2103998436 hasRelatedWork W2396923746 @default.
- W2103998436 hasRelatedWork W2620194898 @default.