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• W2104014673 endingPage "1793" @default.
• W2104014673 startingPage "1790" @default.
• W2104014673 abstract "We isolated a group of genes that are rapidly and transiently induced in 3T3 cells by tetradecanoyl phorbol acetate (TPA). These genes are called TIS genes (for TPA-inducible sequences). Epidermal growth factor (EGF), fibroblast growth factor (FGF), and TPA activated TIS gene expression with similar induction kinetics. TPA pretreatment to deplete protein kinase C activity did not abolish the subsequent induction of TIS gene expression by epidermal growth factor or fibroblast growth factor; both peptide mitogens can activate TIS genes through a protein kinase C-independent pathway(s). We also analyzed TIS gene expression in three TPA-nonproliferative variants (3T3-TNR2, 3T3-TNR9, and A31T6E12A). The results indicate that (i) modulation of a TPA-responsive sodium-potassium-chloride transport system is not necessary for TIS gene induction either by TPA or by other mitogens and (ii) TIS gene induction is not sufficient to guarantee a proliferative response to mitogenic stimulation." @default.
• W2104014673 created "2016-06-24" @default.
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• W2104014673 date "1989-04-01" @default.
• W2104014673 modified "2023-10-13" @default.
• W2104014673 title "Induction of tumor promotor-inducible genes in murine 3T3 cell lines and tetradecanoyl phorbol acetate-nonproliferative 3T3 variants can occur through protein kinase C-dependent and -independent pathways." @default.
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• W2104014673 doi "https://doi.org/10.1128/mcb.9.4.1790" @default.
• W2104014673 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/362599" @default.
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