Matches in SemOpenAlex for { <https://semopenalex.org/work/W2104036338> ?p ?o ?g. }
- W2104036338 endingPage "362" @default.
- W2104036338 startingPage "356" @default.
- W2104036338 abstract "Autocrine stimulation of the epidermal growth factor receptor (EGF-R), by coexpression of transforming growth factor-alpha (TGF-alpha), causes malignant transformation of some fibroblast cell lines. TGF-alpha and EGF-R are both known to be expressed in colon carcinoma tissue and have been shown coexpressed in colon carcinoma cell lines. TGF-alpha autocrine activation of EGF-R has been suggested as a potential mechanism contributing to abnormal growth control in colon cancer. We now report coexpression of TGF-alpha and EGF-R transcripts in morphologically normal colonic epithelium from five individuals, in colonic adenomas from three individuals, and in a nontumorigenic colon adenoma cell line, VACO-330. Functional studies demonstrate VACO-330 growth is stimulated by exogenous TGF-alpha and is completely abolished by a blocking anti-EGF-R antibody. Autocrine stimulation of EGF-R by TGF-alpha is therefore required for growth of the adenoma cell line. Autocrine stimulation of EGF-R by TGF-alpha does not cause malignant transformation of the colonic epithelial cell. In normal and adenomatous human colon TGF-alpha, via either an autocrine or paracrine mechanism, is likely an important physiologic stimulant of epithelial proliferation." @default.
- W2104036338 created "2016-06-24" @default.
- W2104036338 creator A5026295757 @default.
- W2104036338 creator A5040563974 @default.
- W2104036338 creator A5044162217 @default.
- W2104036338 creator A5045151661 @default.
- W2104036338 creator A5047174580 @default.
- W2104036338 creator A5052550785 @default.
- W2104036338 date "1990-07-01" @default.
- W2104036338 modified "2023-10-12" @default.
- W2104036338 title "Growth stimulation by coexpression of transforming growth factor-alpha and epidermal growth factor-receptor in normal and adenomatous human colon epithelium." @default.
- W2104036338 cites W135877420 @default.
- W2104036338 cites W1570686199 @default.
- W2104036338 cites W1627068912 @default.
- W2104036338 cites W1865083834 @default.
- W2104036338 cites W1963534739 @default.
- W2104036338 cites W1969793246 @default.
- W2104036338 cites W1974715669 @default.
- W2104036338 cites W1976467458 @default.
- W2104036338 cites W1982738011 @default.
- W2104036338 cites W1987108079 @default.
- W2104036338 cites W1993797874 @default.
- W2104036338 cites W1995337883 @default.
- W2104036338 cites W2010178768 @default.
- W2104036338 cites W2013199703 @default.
- W2104036338 cites W2014669590 @default.
- W2104036338 cites W2024721720 @default.
- W2104036338 cites W2025690926 @default.
- W2104036338 cites W2033418512 @default.
- W2104036338 cites W2042174183 @default.
- W2104036338 cites W2042202567 @default.
- W2104036338 cites W2046756969 @default.
- W2104036338 cites W2049613194 @default.
- W2104036338 cites W2054012934 @default.
- W2104036338 cites W2068961038 @default.
- W2104036338 cites W2071697240 @default.
- W2104036338 cites W2075300416 @default.
- W2104036338 cites W2093582829 @default.
- W2104036338 cites W2100048123 @default.
- W2104036338 cites W2136811756 @default.
- W2104036338 cites W2139401320 @default.
- W2104036338 cites W2143012843 @default.
- W2104036338 cites W2144910592 @default.
- W2104036338 cites W2146447599 @default.
- W2104036338 cites W2415032506 @default.
- W2104036338 cites W3022691628 @default.
- W2104036338 doi "https://doi.org/10.1172/jci114709" @default.
- W2104036338 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/296730" @default.
- W2104036338 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/2365825" @default.
- W2104036338 hasPublicationYear "1990" @default.
- W2104036338 type Work @default.
- W2104036338 sameAs 2104036338 @default.
- W2104036338 citedByCount "146" @default.
- W2104036338 countsByYear W21040363382012 @default.
- W2104036338 countsByYear W21040363382014 @default.
- W2104036338 countsByYear W21040363382016 @default.
- W2104036338 countsByYear W21040363382017 @default.
- W2104036338 countsByYear W21040363382018 @default.
- W2104036338 countsByYear W21040363382023 @default.
- W2104036338 crossrefType "journal-article" @default.
- W2104036338 hasAuthorship W2104036338A5026295757 @default.
- W2104036338 hasAuthorship W2104036338A5040563974 @default.
- W2104036338 hasAuthorship W2104036338A5044162217 @default.
- W2104036338 hasAuthorship W2104036338A5045151661 @default.
- W2104036338 hasAuthorship W2104036338A5047174580 @default.
- W2104036338 hasAuthorship W2104036338A5052550785 @default.
- W2104036338 hasBestOaLocation W21040363381 @default.
- W2104036338 hasConcept C118131993 @default.
- W2104036338 hasConcept C125555471 @default.
- W2104036338 hasConcept C126322002 @default.
- W2104036338 hasConcept C128240485 @default.
- W2104036338 hasConcept C134018914 @default.
- W2104036338 hasConcept C170493617 @default.
- W2104036338 hasConcept C2775960820 @default.
- W2104036338 hasConcept C2776362946 @default.
- W2104036338 hasConcept C2779438470 @default.
- W2104036338 hasConcept C502942594 @default.
- W2104036338 hasConcept C71924100 @default.
- W2104036338 hasConcept C7876069 @default.
- W2104036338 hasConcept C86803240 @default.
- W2104036338 hasConceptScore W2104036338C118131993 @default.
- W2104036338 hasConceptScore W2104036338C125555471 @default.
- W2104036338 hasConceptScore W2104036338C126322002 @default.
- W2104036338 hasConceptScore W2104036338C128240485 @default.
- W2104036338 hasConceptScore W2104036338C134018914 @default.
- W2104036338 hasConceptScore W2104036338C170493617 @default.
- W2104036338 hasConceptScore W2104036338C2775960820 @default.
- W2104036338 hasConceptScore W2104036338C2776362946 @default.
- W2104036338 hasConceptScore W2104036338C2779438470 @default.
- W2104036338 hasConceptScore W2104036338C502942594 @default.
- W2104036338 hasConceptScore W2104036338C71924100 @default.
- W2104036338 hasConceptScore W2104036338C7876069 @default.
- W2104036338 hasConceptScore W2104036338C86803240 @default.
- W2104036338 hasIssue "1" @default.
- W2104036338 hasLocation W21040363381 @default.
- W2104036338 hasLocation W21040363382 @default.
- W2104036338 hasLocation W21040363383 @default.
- W2104036338 hasLocation W21040363384 @default.