FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2104039523> ?p ?o ?g. }

• W2104039523 endingPage "83" @default.
• W2104039523 startingPage "74" @default.
• W2104039523 abstract "A KPC-producing Klebsiella pneumoniae clone, sequence type (ST) 258, has emerged and spread worldwide. This study aimed to identify putative genes that may contribute to the extraordinary dissemination of the KPC-producing ST258 clone.A suppressive subtractive hybridization (SSH) library was constructed using two KPC-producing strains: an epidemic ST258 and a non-epidemic ST376. The fragments obtained were sequenced, analysed and their presence among 27 additional ST258 isolates and 21 isolates of non-epidemic STs was determined. The functions of the putative proteins were extracted from NCBI databases. Localization to plasmid/chromosome was determined by PCR after transformation and by Southern hybridization. In silico homologues for the subtractive fragments were searched among sequences available in the NCBI database.SSH yielded 42 fragments (50 proteins) specific to the ST258 isolate tested, 30 of them located on various plasmids. The ST258 strains examined could be divided into two groups, one in which all 50 genes were ubiquitous and another group that lost 11 fragments, all located on one of the plasmids. This group of 50 genes was absent among other STs tested. Nineteen genes were unique to ST258 strains and 17 to CC258 (where CC stands for clonal complex). Most of the deduced proteins belonged to two major functional groups: 15 to the cell motility and secretion group, and 14 to the DNA repair and modification group.This study identifies unique genes in ST258 bacteria that may contribute to its epidemiological success as compared with other KPC-producing STs. Conservation of plasmid-encoded genes among ST258 isolates, despite plasmid variation, supports their importance in the success of this clone." @default.
• W2104039523 created "2016-06-24" @default.
• W2104039523 creator A5007118893 @default.
• W2104039523 creator A5023479710 @default.
• W2104039523 creator A5042242482 @default.
• W2104039523 creator A5060861733 @default.
• W2104039523 creator A5064199125 @default.
• W2104039523 creator A5067050784 @default.
• W2104039523 date "2012-10-04" @default.
• W2104039523 modified "2023-09-27" @default.
• W2104039523 title "Unique genes identified in the epidemic extremely drug-resistant KPC-producing Klebsiella pneumoniae sequence type 258" @default.
• W2104039523 cites W1572432080 @default.
• W2104039523 cites W1701246587 @default.
• W2104039523 cites W1983899475 @default.
• W2104039523 cites W1995886460 @default.
• W2104039523 cites W1999582761 @default.
• W2104039523 cites W2003311354 @default.
• W2104039523 cites W2008294421 @default.
• W2104039523 cites W2024082670 @default.
• W2104039523 cites W2025934004 @default.
• W2104039523 cites W2035333716 @default.
• W2104039523 cites W2056633937 @default.
• W2104039523 cites W2056705393 @default.
• W2104039523 cites W2061259593 @default.
• W2104039523 cites W2087524417 @default.
• W2104039523 cites W2087865186 @default.
• W2104039523 cites W2096167173 @default.
• W2104039523 cites W2099384461 @default.
• W2104039523 cites W2100918802 @default.
• W2104039523 cites W2103171109 @default.
• W2104039523 cites W2116656658 @default.
• W2104039523 cites W2135554570 @default.
• W2104039523 cites W2142513910 @default.
• W2104039523 cites W2147869315 @default.
• W2104039523 cites W2153679512 @default.
• W2104039523 cites W2154955845 @default.
• W2104039523 cites W2158541189 @default.
• W2104039523 cites W2168606178 @default.
• W2104039523 cites W2172185686 @default.
• W2104039523 cites W2180739100 @default.
• W2104039523 doi "https://doi.org/10.1093/jac/dks370" @default.
• W2104039523 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/23042812" @default.
• W2104039523 hasPublicationYear "2012" @default.
• W2104039523 type Work @default.
• W2104039523 sameAs 2104039523 @default.
• W2104039523 citedByCount "42" @default.
• W2104039523 countsByYear W21040395232013 @default.
• W2104039523 countsByYear W21040395232014 @default.
• W2104039523 countsByYear W21040395232015 @default.
• W2104039523 countsByYear W21040395232016 @default.
• W2104039523 countsByYear W21040395232017 @default.
• W2104039523 countsByYear W21040395232018 @default.
• W2104039523 countsByYear W21040395232019 @default.
• W2104039523 countsByYear W21040395232020 @default.
• W2104039523 countsByYear W21040395232022 @default.
• W2104039523 countsByYear W21040395232023 @default.
• W2104039523 crossrefType "journal-article" @default.
• W2104039523 hasAuthorship W2104039523A5007118893 @default.
• W2104039523 hasAuthorship W2104039523A5023479710 @default.
• W2104039523 hasAuthorship W2104039523A5042242482 @default.
• W2104039523 hasAuthorship W2104039523A5060861733 @default.
• W2104039523 hasAuthorship W2104039523A5064199125 @default.
• W2104039523 hasAuthorship W2104039523A5067050784 @default.
• W2104039523 hasConcept C104317684 @default.
• W2104039523 hasConcept C167625842 @default.
• W2104039523 hasConcept C189482833 @default.
• W2104039523 hasConcept C196436469 @default.
• W2104039523 hasConcept C22744801 @default.
• W2104039523 hasConcept C2775905019 @default.
• W2104039523 hasConcept C2777058267 @default.
• W2104039523 hasConcept C54355233 @default.
• W2104039523 hasConcept C547475151 @default.
• W2104039523 hasConcept C61053724 @default.
• W2104039523 hasConcept C81089528 @default.
• W2104039523 hasConcept C86803240 @default.
• W2104039523 hasConcept C89423630 @default.
• W2104039523 hasConceptScore W2104039523C104317684 @default.
• W2104039523 hasConceptScore W2104039523C167625842 @default.
• W2104039523 hasConceptScore W2104039523C189482833 @default.
• W2104039523 hasConceptScore W2104039523C196436469 @default.
• W2104039523 hasConceptScore W2104039523C22744801 @default.
• W2104039523 hasConceptScore W2104039523C2775905019 @default.
• W2104039523 hasConceptScore W2104039523C2777058267 @default.
• W2104039523 hasConceptScore W2104039523C54355233 @default.
• W2104039523 hasConceptScore W2104039523C547475151 @default.
• W2104039523 hasConceptScore W2104039523C61053724 @default.
• W2104039523 hasConceptScore W2104039523C81089528 @default.
• W2104039523 hasConceptScore W2104039523C86803240 @default.
• W2104039523 hasConceptScore W2104039523C89423630 @default.
• W2104039523 hasIssue "1" @default.
• W2104039523 hasLocation W21040395231 @default.
• W2104039523 hasLocation W21040395232 @default.
• W2104039523 hasOpenAccess W2104039523 @default.
• W2104039523 hasPrimaryLocation W21040395231 @default.
• W2104039523 hasRelatedWork W1980009488 @default.
• W2104039523 hasRelatedWork W1982073117 @default.
• W2104039523 hasRelatedWork W1985426194 @default.
• W2104039523 hasRelatedWork W2064112457 @default.

• next