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• W2104061566 abstract "A polymorphism for the phase I drug-metabolizing enzyme, flavin-containing monooxygenase isoform 2 (FMO2), encoding either truncated inactive protein, FMO2X472 (FMO2.2A), or full-length active enzyme, FMO2Q472 (FMO2.1), is known and exhibits significant interethnic differences in allelic frequency. FMO2 is the major or sole FMO isoform expressed in the lung of most mammals, including nonhuman primates. To date, FMO2.1 has been found only in African-American and Hispanic populations, rendering individuals with this allele subject to drug metabolism that is potentially different from that of the general population. Approximately 26% of African-Americans (<i>n</i> = 180) possess the <i>FMO2^*1</i> allele. In preliminary studies, we initially estimated that 5% of Hispanics (<i>n</i> = 40) have the <i>FMO2^*1</i> allele, but access to large cohorts of individuals of defined national origin has allowed us to determine the occurrence among Mexican-American and Puerto Rican-American groups. We used allele-specific genotyping to detect <i>FMO2^*1</i> from 632 Hispanic individuals, including 280 individuals of Mexican origin and 327 individuals of Puerto Rican origin. Statistical analysis indicated that results from Mexican (five sample sources) and Puerto Rican (three sample sources) samples were consistent with the hypothesis of homogeneity within each group from different sources. Data were subsequently pooled across sources to test for evidence of a difference in occurrence of <i>FMO2^*1</i> between ethnic groups. There was strong evidence (<i>p</i> = 0.0066) that <i>FMO2^*1</i> is more common among Puerto Ricans (7%) than among individuals of Mexican descent (2%). The overall occurrence of <i>FMO2^*1</i> among Hispanics of all origins is estimated to be between 2 and 7%." @default.
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• W2104061566 date "2013-05-09" @default.
• W2104061566 modified "2023-10-18" @default.
• W2104061566 title "Heat shock protein 90 (Hsp90) inhibition targets canonical TGF-β signalling to prevent fibrosis" @default.
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• W2104061566 doi "https://doi.org/10.1136/annrheumdis-2012-203095" @default.
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