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• W2104078014 abstract "An investigation on the secondary metabolites from the BuOH extract of the fermentation broth of the thermotolerant polyester-degrading actinomycete Actinomadura miaoliensis BCRC 16873 was carried out. One previously undescribed α-pyrone (=pyran-2-one) derivative, designated as miaolienone (1), and a new butanolide, miaolinolide (2), together with 13 known compounds, 3–15, were obtained. Their structures were established on the basis of extensive 1D- and 2D-NMR analyses in combination with HR-MS experiments. In addition, the isolated compounds 1–15 were evaluated for the inhibitory effects of the isolates on the production of tumor necrosis factor (TNF-α) induced by lipopolysaccharide (LPS). Among the isolates, 1 and 2 significantly inhibited TNF-α production in U937 cells in vitro, and the IC50 values were 0.59 and 0.76 μM, respectively. Compounds 3–5 displayed moderate inhibitory activities on LPS-induced TNF-α production." @default.
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• W2104078014 date "2013-02-01" @default.
• W2104078014 modified "2023-10-17" @default.
• W2104078014 title "Chemical Constituents from a Soil-Derived Actinomycete,Actinomadura miaoliensisBCRC 16873, and Their Inhibitory Activities on Lipopolysaccharide-Induced Tumor Necrosis Factor Production" @default.
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• W2104078014 doi "https://doi.org/10.1002/cbdv.201200242" @default.
• W2104078014 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/23418178" @default.
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