Matches in SemOpenAlex for { <https://semopenalex.org/work/W2104080379> ?p ?o ?g. }
- W2104080379 endingPage "2668" @default.
- W2104080379 startingPage "2653" @default.
- W2104080379 abstract "The risk of osteoporotic fractures is currently estimated based on an assessment of bone mass as measured by dual-energy X-ray absorptiometry. However, patient-specific finite element (FE) simulations that include information from multiple scales have the potential to allow more accurate prognosis. In the past, FE models of bone were limited either in resolution or to the linearization of the mechanical behaviour. Now, nonlinear, high-resolution simulations including the bone microstructure have been made possible by recent advances in simulation methods, computer infrastructure and imaging, allowing the implementation of multiscale modelling schemes. For example, the mechanical loads generated in the musculoskeletal system define the boundary conditions for organ-level, continuum-based FE models, whose nonlinear material properties are derived from microstructural information. Similarly microstructure models include tissue-level information such as the dynamic behaviour of collagen by modifying the model's constitutive law. This multiscale approach to modelling the mechanics of bone allows a more accurate characterization of bone fracture behaviour. Furthermore, such models could also include the effects of ageing, osteoporosis and drug treatment. Here we present the current state of the art for multiscale modelling and assess its potential to better predict an individual's risk of fracture in a clinical setting." @default.
- W2104080379 created "2016-06-24" @default.
- W2104080379 creator A5032552737 @default.
- W2104080379 creator A5037956106 @default.
- W2104080379 creator A5047424582 @default.
- W2104080379 date "2010-06-13" @default.
- W2104080379 modified "2023-10-10" @default.
- W2104080379 title "Multiscale modelling and nonlinear finite element analysis as clinical tools for the assessment of fracture risk" @default.
- W2104080379 cites W1634360593 @default.
- W2104080379 cites W1965020770 @default.
- W2104080379 cites W1971135869 @default.
- W2104080379 cites W1972190722 @default.
- W2104080379 cites W1974356581 @default.
- W2104080379 cites W1976387068 @default.
- W2104080379 cites W1977337999 @default.
- W2104080379 cites W1979128079 @default.
- W2104080379 cites W1981054600 @default.
- W2104080379 cites W1981821619 @default.
- W2104080379 cites W1984006923 @default.
- W2104080379 cites W1986307454 @default.
- W2104080379 cites W1989783674 @default.
- W2104080379 cites W1990236295 @default.
- W2104080379 cites W1990733884 @default.
- W2104080379 cites W1994669017 @default.
- W2104080379 cites W2000461506 @default.
- W2104080379 cites W2000466578 @default.
- W2104080379 cites W2003092614 @default.
- W2104080379 cites W2006689445 @default.
- W2104080379 cites W2009222457 @default.
- W2104080379 cites W2009364506 @default.
- W2104080379 cites W2009664761 @default.
- W2104080379 cites W2011272591 @default.
- W2104080379 cites W2023115269 @default.
- W2104080379 cites W2023425023 @default.
- W2104080379 cites W2023878636 @default.
- W2104080379 cites W2029097920 @default.
- W2104080379 cites W2035485049 @default.
- W2104080379 cites W2037189818 @default.
- W2104080379 cites W2040873725 @default.
- W2104080379 cites W2041598849 @default.
- W2104080379 cites W2046515561 @default.
- W2104080379 cites W2053278205 @default.
- W2104080379 cites W2053486661 @default.
- W2104080379 cites W2054622923 @default.
- W2104080379 cites W2054689187 @default.
- W2104080379 cites W2059579312 @default.
- W2104080379 cites W2062680483 @default.
- W2104080379 cites W2064040931 @default.
- W2104080379 cites W2066646366 @default.
- W2104080379 cites W2069876858 @default.
- W2104080379 cites W2070914367 @default.
- W2104080379 cites W2072231974 @default.
- W2104080379 cites W2075125648 @default.
- W2104080379 cites W2076349714 @default.
- W2104080379 cites W2079471688 @default.
- W2104080379 cites W2080977367 @default.
- W2104080379 cites W2084189654 @default.
- W2104080379 cites W2088713190 @default.
- W2104080379 cites W2089968363 @default.
- W2104080379 cites W2090510711 @default.
- W2104080379 cites W2092654589 @default.
- W2104080379 cites W2095150495 @default.
- W2104080379 cites W2099359603 @default.
- W2104080379 cites W2101214241 @default.
- W2104080379 cites W2102087333 @default.
- W2104080379 cites W2105510043 @default.
- W2104080379 cites W2105662848 @default.
- W2104080379 cites W2112095335 @default.
- W2104080379 cites W2112488161 @default.
- W2104080379 cites W2113523811 @default.
- W2104080379 cites W2116790651 @default.
- W2104080379 cites W2119774121 @default.
- W2104080379 cites W2126186101 @default.
- W2104080379 cites W2128569032 @default.
- W2104080379 cites W2135372180 @default.
- W2104080379 cites W2135587550 @default.
- W2104080379 cites W2138850160 @default.
- W2104080379 cites W2145352132 @default.
- W2104080379 cites W2147123976 @default.
- W2104080379 cites W2149181963 @default.
- W2104080379 cites W2150578923 @default.
- W2104080379 cites W2153009489 @default.
- W2104080379 cites W2156139503 @default.
- W2104080379 cites W2159591750 @default.
- W2104080379 cites W2159612519 @default.
- W2104080379 cites W2159775719 @default.
- W2104080379 cites W2164057611 @default.
- W2104080379 cites W2171726833 @default.
- W2104080379 cites W2323830513 @default.
- W2104080379 doi "https://doi.org/10.1098/rsta.2010.0041" @default.
- W2104080379 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/20439267" @default.
- W2104080379 hasPublicationYear "2010" @default.
- W2104080379 type Work @default.
- W2104080379 sameAs 2104080379 @default.
- W2104080379 citedByCount "47" @default.
- W2104080379 countsByYear W21040803792012 @default.
- W2104080379 countsByYear W21040803792013 @default.
- W2104080379 countsByYear W21040803792014 @default.