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- W2104083947 endingPage "R299" @default.
- W2104083947 startingPage "R291" @default.
- W2104083947 abstract "The data summarized here suggest the existence of a new central pathway for the hormonal regulation of pain. These data mainly collected in quail, a useful model in neuroendocrinology, demonstrate that numerous neurons in the superficial laminae of the spinal cord express aromatase (estrogen-synthase). Chronic and systemic blockade of this enzyme in quail alters nociception within days, indicating that the slow genomic effects of sex steroids on nociception classically observed in mammals also occur in birds and require aromatization of androgens into estrogens. However, by contrast with these slow effects, acute intrathecal inhibition of aromatase in restricted spinal cord segments reveals that estrogens can also control nociception much faster, within 1 min, presumably through the activation of a nongenomic pathway and in a manner that depends on an immediate response to fast activation/deactivation of local aromatase activity. This emergent central and rapid paracrine mechanism might permit instantaneous and segment-specific changes in pain sensitivity; it draws new interesting perspectives for the study of the estrogenic control of pain, thus far limited to the classical view of slow genomic changes in pain, depending on peripheral estrogens. The expression of aromatase in the spinal cord in other species and in other central nociception-related areas is also briefly discussed." @default.
- W2104083947 created "2016-06-24" @default.
- W2104083947 creator A5047886911 @default.
- W2104083947 date "2006-08-01" @default.
- W2104083947 modified "2023-10-14" @default.
- W2104083947 title "Estrogen synthesis in the spinal dorsal horn: a new central mechanism for the hormonal regulation of pain" @default.
- W2104083947 cites W1564842764 @default.
- W2104083947 cites W1567320500 @default.
- W2104083947 cites W1635709196 @default.
- W2104083947 cites W1874127120 @default.
- W2104083947 cites W1914841629 @default.
- W2104083947 cites W1963831656 @default.
- W2104083947 cites W1964713447 @default.
- W2104083947 cites W1964726163 @default.
- W2104083947 cites W1965716707 @default.
- W2104083947 cites W1970261756 @default.
- W2104083947 cites W1971396498 @default.
- W2104083947 cites W1975909673 @default.
- W2104083947 cites W1976862945 @default.
- W2104083947 cites W1977521541 @default.
- W2104083947 cites W1977871606 @default.
- W2104083947 cites W1983078327 @default.
- W2104083947 cites W1985991717 @default.
- W2104083947 cites W1986938347 @default.
- W2104083947 cites W1991346696 @default.
- W2104083947 cites W1991354484 @default.
- W2104083947 cites W1991803109 @default.
- W2104083947 cites W1994874098 @default.
- W2104083947 cites W1995328767 @default.
- W2104083947 cites W1995418087 @default.
- W2104083947 cites W1995538566 @default.
- W2104083947 cites W1998363045 @default.
- W2104083947 cites W2002417808 @default.
- W2104083947 cites W2004542686 @default.
- W2104083947 cites W2005737804 @default.
- W2104083947 cites W2009747539 @default.
- W2104083947 cites W2011204006 @default.
- W2104083947 cites W2017336787 @default.
- W2104083947 cites W2022743236 @default.
- W2104083947 cites W2023131011 @default.
- W2104083947 cites W2023421608 @default.
- W2104083947 cites W2023702492 @default.
- W2104083947 cites W2024899367 @default.
- W2104083947 cites W2026805882 @default.
- W2104083947 cites W2026982851 @default.
- W2104083947 cites W2029184841 @default.
- W2104083947 cites W2030402917 @default.
- W2104083947 cites W2033580253 @default.
- W2104083947 cites W2037106816 @default.
- W2104083947 cites W2037878404 @default.
- W2104083947 cites W2038300767 @default.
- W2104083947 cites W2041403270 @default.
- W2104083947 cites W2047754415 @default.
- W2104083947 cites W2050581082 @default.
- W2104083947 cites W2051872929 @default.
- W2104083947 cites W2053652280 @default.
- W2104083947 cites W2056925622 @default.
- W2104083947 cites W2056946851 @default.
- W2104083947 cites W2058253354 @default.
- W2104083947 cites W2058335420 @default.
- W2104083947 cites W2060293957 @default.
- W2104083947 cites W2060838533 @default.
- W2104083947 cites W2062866484 @default.
- W2104083947 cites W2067030363 @default.
- W2104083947 cites W2067576846 @default.
- W2104083947 cites W2067648897 @default.
- W2104083947 cites W2067671381 @default.
- W2104083947 cites W2069940102 @default.
- W2104083947 cites W2070991102 @default.
- W2104083947 cites W2073162601 @default.
- W2104083947 cites W2075501422 @default.
- W2104083947 cites W2076405008 @default.
- W2104083947 cites W2078288264 @default.
- W2104083947 cites W2079279025 @default.
- W2104083947 cites W2080987913 @default.
- W2104083947 cites W2082655961 @default.
- W2104083947 cites W2084230118 @default.
- W2104083947 cites W2086926709 @default.
- W2104083947 cites W2087185690 @default.
- W2104083947 cites W2087253950 @default.
- W2104083947 cites W2092171701 @default.
- W2104083947 cites W2093109806 @default.
- W2104083947 cites W2097618455 @default.
- W2104083947 cites W2100955793 @default.
- W2104083947 cites W2101395256 @default.
- W2104083947 cites W2114600077 @default.
- W2104083947 cites W2123258170 @default.
- W2104083947 cites W2130882528 @default.
- W2104083947 cites W2132320691 @default.
- W2104083947 cites W2134852027 @default.
- W2104083947 cites W2137272726 @default.
- W2104083947 cites W2141300941 @default.
- W2104083947 cites W2145865543 @default.
- W2104083947 cites W2152141678 @default.
- W2104083947 cites W2158369385 @default.
- W2104083947 cites W2164545368 @default.
- W2104083947 cites W2166479364 @default.
- W2104083947 cites W2168132586 @default.