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- W2104087667 abstract "Overexpression of matrix metalloproteinases (MMPs) facilitates tumor cell invasion. Synthetic MMP inhibitors such as batimastat have been designed to treat cancer. We report that because of batimastat treatment, human breast carcinoma cells metastasized to the liver in nude mice and that an increase of liver metastases of murine T-cell lymphoma cells was observed in syngeneic mice. Batimastat treatment also caused liver-specific overexpression of MMPs-2, -9, and mRNA up-regulation of angiogenesis factors and caspase-1, even in tumor-free animals. Induction of organ-specific side effects need to be taken into account regarding further development and clinical use of synthetic MMP inhibitors." @default.
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- W2104087667 date "2001-02-15" @default.
- W2104087667 modified "2023-09-23" @default.
- W2104087667 title "Hydroxamate-type matrix metalloproteinase inhibitor batimastat promotes liver metastasis." @default.
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