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- W2104090970 abstract "The homeobox genes are a large and diverse group of genes, many of which play important roles in the embryonic development of animals. Increasingly, homeobox genes are being compared between genomes in an attempt to understand the evolution of animal development. Despite their importance, the full diversity of human homeobox genes has not previously been described. We have identified all homeobox genes and pseudogenes in the euchromatic regions of the human genome, finding many unannotated, incorrectly annotated, unnamed, misnamed or misclassified genes and pseudogenes. We describe 300 human homeobox loci, which we divide into 235 probable functional genes and 65 probable pseudogenes. These totals include 3 genes with partial homeoboxes and 13 pseudogenes that lack homeoboxes but are clearly derived from homeobox genes. These figures exclude the repetitive DUX1 to DUX5 homeobox sequences of which we identified 35 probable pseudogenes, with many more expected in heterochromatic regions. Nomenclature is established for approximately 40 formerly unnamed loci, reflecting their evolutionary relationships to other loci in human and other species, and nomenclature revisions are proposed for around 30 other loci. We use a classification that recognizes 11 homeobox gene 'classes' subdivided into 102 homeobox gene 'families'. We have conducted a comprehensive survey of homeobox genes and pseudogenes in the human genome, described many new loci, and revised the classification and nomenclature of homeobox genes. The classification scheme may be widely applicable to homeobox genes in other animal genomes and will facilitate comparative genomics of this important gene superclass." @default.
- W2104090970 created "2016-06-24" @default.
- W2104090970 creator A5028356669 @default.
- W2104090970 creator A5028440222 @default.
- W2104090970 creator A5039339170 @default.
- W2104090970 date "2007-10-26" @default.
- W2104090970 modified "2023-10-10" @default.
- W2104090970 title "Classification and nomenclature of all human homeobox genes" @default.
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- W2104090970 doi "https://doi.org/10.1186/1741-7007-5-47" @default.
- W2104090970 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/2211742" @default.
- W2104090970 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/17963489" @default.
- W2104090970 hasPublicationYear "2007" @default.