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- W2104096033 abstract "Abstract Multiple myeloma (MM) is the second most common hematological malignancy in adults. It is characterized by clonal proliferation of terminally differentiated B lymphocytes and over-production of monoclonal immunoglobulins. Recurrent genomic aberrations have been identified to contribute to the aggressiveness of this cancer. Despite a wealth of knowledge describing the molecular biology of MM as well as significant advances in therapeutics, this disease remains fatal. The identification of biomarkers, especially through the use of mass spectrometry, however, holds great promise to increasing our understanding of this disease. In particular, novel biomarkers will help in the diagnosis, prognosis and therapeutic stratification of MM. To date, results from mass spectrometry studies of MM have provided valuable information with regards to MM diagnosis and response to therapy. In addition, mass spectrometry was employed to study relevant signaling pathways activated in MM. This review will focus on how mass spectrometry has been applied to increase our understanding of MM." @default.
- W2104096033 created "2016-06-24" @default.
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- W2104096033 date "2010-04-07" @default.
- W2104096033 modified "2023-10-12" @default.
- W2104096033 title "Applying mass spectrometry based proteomic technology to advance the understanding of multiple myeloma" @default.
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- W2104096033 doi "https://doi.org/10.1186/1756-8722-3-13" @default.
- W2104096033 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/2868782" @default.
- W2104096033 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/20374647" @default.
- W2104096033 hasPublicationYear "2010" @default.
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