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- W2104110801 abstract "The responsiveness of mouse spleen cells to phytohemagglutinin (PHA) and lipopolysaccharide(LPS) was depressed during pregnancy, especially in the early and late phase. In order to explain this, various pregnancy-related hormones were tested in terms of their effect on in vitro proliferative activity of lymphocytes when stimulated with either PHA or LPS. It was revealed that progesterone and corticosteroid were the moat effective hormones to suppress in vitro proliferative activity of lymphocytes at the physiological level of concentration. The responsiveness of spleen cells to PHA was more susceptible to progesterone than that to LPS, and female spleen cells were more susceptible to progesterone than male ones. HCG did not show apparent suppressive effect on the responsiveness of spleen cells to the mitogens, but to the contrary showed slight enhancing effect on that. Prolactin and estriol did not show any apparent effect on the mitogenic responsiveness of lymphocytes." @default.
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- W2104110801 date "1979-11-01" @default.
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- W2104110801 title "EFFECT OF PREGNANCY AND ITS RELATED HORMONES ON THEIN VITROPROLIFERATIVE ACTIVITY OF MOUSE SPLEEN CELLS" @default.
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- W2104110801 doi "https://doi.org/10.1111/j.1440-1827.1979.tb00949.x" @default.
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