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- W2104111566 abstract "The replicative properties of influenza virus hemagglutinin (HA) mutants with altered receptor binding characteristics were analyzed following intranasal inoculation of mice. Among the mutants examined was a virus containing a Y98F substitution at a conserved position in the receptor binding site that leads to a 20-fold reduction in binding. This mutant can replicate as well as wild-type (WT) virus in MDCK cells and in embryonated chicken eggs but is highly attenuated in mice, exhibiting titers in lungs more than 1,000-fold lower than those of the WT. The capacity of the Y98F mutant to induce antibody responses and the structural locations of HA reversion mutations are examined." @default.
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- W2104111566 date "2008-05-15" @default.
- W2104111566 modified "2023-09-25" @default.
- W2104111566 title "Infectivity Studies of Influenza Virus Hemagglutinin Receptor Binding Site Mutants in Mice" @default.
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- W2104111566 doi "https://doi.org/10.1128/jvi.01958-07" @default.
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