FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2104116219> ?p ?o ?g. }

• W2104116219 endingPage "845" @default.
• W2104116219 startingPage "840" @default.
• W2104116219 abstract "In biological systems, the Keap1/Nrf2/antioxidant response element pathway determines the ability of mammalian cells to adapt and survive conditions of oxidative, electrophilic and inflammatory stress by regulating the production of cytoprotective enzymes NAD(P)H:quinone oxidoreductase 1 (NQO1, EC 1.6.99.2) being one of them. Novel biologically active benzenesulfonamides 2, 3, 5–7, penta-2,4-dienamide 4 and chromene-2-carboxamide 8 structurally augmented with an electron-deficient Michael acceptor enone or cyanoenone functionalities were prepared. A new biological activity was conferred to these molecules, that of induction of NQO1. The potency of induction was increased by incorporation of a nitrile group adjacent to the enone and the dinitrophenyl derivative 3 was the most promising inducer. Also, molecular docking of the new compounds in the Nrf2-binding site of Keap1 was performed to assess their ability to inhibit Keap1 which biologically leads to a consequent Nrf2 accumulation and enhanced gene expression of NQO1. Docking results showed considerable interactions between the new molecules and essential binding site amino acids." @default.
• W2104116219 created "2016-06-24" @default.
• W2104116219 creator A5021453491 @default.
• W2104116219 creator A5023781365 @default.
• W2104116219 creator A5027312599 @default.
• W2104116219 creator A5035959895 @default.
• W2104116219 creator A5053120398 @default.
• W2104116219 creator A5089167604 @default.
• W2104116219 date "2014-01-14" @default.
• W2104116219 modified "2023-09-23" @default.
• W2104116219 title "Synthesis, molecular modeling and NAD(P)H:quinone oxidoreductase 1 inducer activity of novel cyanoenone and enone benzenesulfonamides" @default.
• W2104116219 cites W1767659454 @default.
• W2104116219 cites W1785455093 @default.
• W2104116219 cites W1964307147 @default.
• W2104116219 cites W1964324812 @default.
• W2104116219 cites W1966830269 @default.
• W2104116219 cites W1991631628 @default.
• W2104116219 cites W1994458390 @default.
• W2104116219 cites W1995182810 @default.
• W2104116219 cites W2005338120 @default.
• W2104116219 cites W2018918340 @default.
• W2104116219 cites W2022582116 @default.
• W2104116219 cites W2028274066 @default.
• W2104116219 cites W2029377269 @default.
• W2104116219 cites W2037233027 @default.
• W2104116219 cites W2047178318 @default.
• W2104116219 cites W2050574267 @default.
• W2104116219 cites W2059882356 @default.
• W2104116219 cites W2069159655 @default.
• W2104116219 cites W2089585797 @default.
• W2104116219 cites W2097524602 @default.
• W2104116219 cites W2111272340 @default.
• W2104116219 cites W2118954181 @default.
• W2104116219 cites W2135572561 @default.
• W2104116219 cites W2146558971 @default.
• W2104116219 cites W2149567364 @default.
• W2104116219 cites W2153977062 @default.
• W2104116219 cites W2162956728 @default.
• W2104116219 doi "https://doi.org/10.3109/14756366.2013.858146" @default.
• W2104116219 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/24417210" @default.
• W2104116219 hasPublicationYear "2014" @default.
• W2104116219 type Work @default.
• W2104116219 sameAs 2104116219 @default.
• W2104116219 citedByCount "6" @default.
• W2104116219 countsByYear W21041162192016 @default.
• W2104116219 crossrefType "journal-article" @default.
• W2104116219 hasAuthorship W2104116219A5021453491 @default.
• W2104116219 hasAuthorship W2104116219A5023781365 @default.
• W2104116219 hasAuthorship W2104116219A5027312599 @default.
• W2104116219 hasAuthorship W2104116219A5035959895 @default.
• W2104116219 hasAuthorship W2104116219A5053120398 @default.
• W2104116219 hasAuthorship W2104116219A5089167604 @default.
• W2104116219 hasConcept C104317684 @default.
• W2104116219 hasConcept C159110408 @default.
• W2104116219 hasConcept C161790260 @default.
• W2104116219 hasConcept C181199279 @default.
• W2104116219 hasConcept C185592680 @default.
• W2104116219 hasConcept C2776529522 @default.
• W2104116219 hasConcept C2779268744 @default.
• W2104116219 hasConcept C2779746879 @default.
• W2104116219 hasConcept C2780643102 @default.
• W2104116219 hasConcept C41183919 @default.
• W2104116219 hasConcept C41685203 @default.
• W2104116219 hasConcept C50027330 @default.
• W2104116219 hasConcept C55493867 @default.
• W2104116219 hasConcept C71240020 @default.
• W2104116219 hasConcept C71924100 @default.
• W2104116219 hasConcept C75520062 @default.
• W2104116219 hasConcept C86339819 @default.
• W2104116219 hasConceptScore W2104116219C104317684 @default.
• W2104116219 hasConceptScore W2104116219C159110408 @default.
• W2104116219 hasConceptScore W2104116219C161790260 @default.
• W2104116219 hasConceptScore W2104116219C181199279 @default.
• W2104116219 hasConceptScore W2104116219C185592680 @default.
• W2104116219 hasConceptScore W2104116219C2776529522 @default.
• W2104116219 hasConceptScore W2104116219C2779268744 @default.
• W2104116219 hasConceptScore W2104116219C2779746879 @default.
• W2104116219 hasConceptScore W2104116219C2780643102 @default.
• W2104116219 hasConceptScore W2104116219C41183919 @default.
• W2104116219 hasConceptScore W2104116219C41685203 @default.
• W2104116219 hasConceptScore W2104116219C50027330 @default.
• W2104116219 hasConceptScore W2104116219C55493867 @default.
• W2104116219 hasConceptScore W2104116219C71240020 @default.
• W2104116219 hasConceptScore W2104116219C71924100 @default.
• W2104116219 hasConceptScore W2104116219C75520062 @default.
• W2104116219 hasConceptScore W2104116219C86339819 @default.
• W2104116219 hasIssue "6" @default.
• W2104116219 hasLocation W21041162191 @default.
• W2104116219 hasLocation W21041162192 @default.
• W2104116219 hasOpenAccess W2104116219 @default.
• W2104116219 hasPrimaryLocation W21041162191 @default.
• W2104116219 hasRelatedWork W1542448467 @default.
• W2104116219 hasRelatedWork W1656364975 @default.
• W2104116219 hasRelatedWork W1953994264 @default.
• W2104116219 hasRelatedWork W1968130089 @default.
• W2104116219 hasRelatedWork W2074191566 @default.
• W2104116219 hasRelatedWork W2089869974 @default.
• W2104116219 hasRelatedWork W2103801137 @default.

• next