FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2104130003> ?p ?o ?g. }

• W2104130003 endingPage "537" @default.
• W2104130003 startingPage "531" @default.
• W2104130003 abstract "The finding of melanoma cells in the peripheral blood, thus far mainly inferred from the PCR-based demonstration of tyrosinase mRNA, has been associated with metastatic melanoma. Neither the malignant nature nor the prognostic significance of circulating cells could be established. To address this question, we analyzed immunomagnetically isolated circulating melanoma cells for chromosomal aberrations and performed a clinical follow-up study of the enrolled patients.In a prospective study, blood samples were taken from 164 melanoma patients and 50 donors without malignant disease. Circulating melanoma cells were enriched by immunomagnetic cell sorting using a murine monoclonal antibody against the melanoma-associated chondroitin sulfate proteoglycan. To prove the malignant origin of the positive cells and to define their chromosomal aberrations, we analyzed the genomes of 15 individually isolated cells from seven patients by single-cell comparative genomic hybridization (SCOMP).Absolute and relative frequencies of circulating melanoma cells were associated with stage and with the presence or absence of detectable tumor. The detection of two or more cells correlated significantly with a reduced survival of patients with metastatic melanoma. All of the cells that were analyzed by SCOMP displayed multiple chromosomal changes and carried aberrations typical for melanoma.Immunomagnetic enrichment enables isolation and genomic characterization of circulating melanoma cells. The prognostic impact on survival of metastatic patients apparently reflects the aggressiveness of an ongoing tumor spread. Direct genomic analysis of the enriched and isolated cells will help to clarify the molecular-genetic basis of the establishment of generalized melanoma." @default.
• W2104130003 created "2016-06-24" @default.
• W2104130003 creator A5001528551 @default.
• W2104130003 creator A5006272268 @default.
• W2104130003 creator A5032790832 @default.
• W2104130003 creator A5041627641 @default.
• W2104130003 creator A5062859124 @default.
• W2104130003 creator A5065462815 @default.
• W2104130003 creator A5081020577 @default.
• W2104130003 creator A5085166008 @default.
• W2104130003 date "2004-01-15" @default.
• W2104130003 modified "2023-09-23" @default.
• W2104130003 title "Immunomagnetic Enrichment, Genomic Characterization, and Prognostic Impact of Circulating Melanoma Cells" @default.
• W2104130003 cites W1484187172 @default.
• W2104130003 cites W1890097486 @default.
• W2104130003 cites W1949238489 @default.
• W2104130003 cites W1962027022 @default.
• W2104130003 cites W1975679429 @default.
• W2104130003 cites W1979847210 @default.
• W2104130003 cites W1989215251 @default.
• W2104130003 cites W2001883065 @default.
• W2104130003 cites W2005653678 @default.
• W2104130003 cites W2007905457 @default.
• W2104130003 cites W2080273889 @default.
• W2104130003 cites W2086757725 @default.
• W2104130003 cites W2093037100 @default.
• W2104130003 cites W2108122736 @default.
• W2104130003 cites W2138022504 @default.
• W2104130003 cites W2170828133 @default.
• W2104130003 cites W2171662481 @default.
• W2104130003 cites W2221217355 @default.
• W2104130003 cites W70196639 @default.
• W2104130003 doi "https://doi.org/10.1158/1078-0432.ccr-0424-03" @default.
• W2104130003 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/14760074" @default.
• W2104130003 hasPublicationYear "2004" @default.
• W2104130003 type Work @default.
• W2104130003 sameAs 2104130003 @default.
• W2104130003 citedByCount "110" @default.
• W2104130003 countsByYear W21041300032012 @default.
• W2104130003 countsByYear W21041300032013 @default.
• W2104130003 countsByYear W21041300032014 @default.
• W2104130003 countsByYear W21041300032015 @default.
• W2104130003 countsByYear W21041300032016 @default.
• W2104130003 countsByYear W21041300032017 @default.
• W2104130003 countsByYear W21041300032018 @default.
• W2104130003 countsByYear W21041300032019 @default.
• W2104130003 countsByYear W21041300032020 @default.
• W2104130003 countsByYear W21041300032021 @default.
• W2104130003 countsByYear W21041300032022 @default.
• W2104130003 crossrefType "journal-article" @default.
• W2104130003 hasAuthorship W2104130003A5001528551 @default.
• W2104130003 hasAuthorship W2104130003A5006272268 @default.
• W2104130003 hasAuthorship W2104130003A5032790832 @default.
• W2104130003 hasAuthorship W2104130003A5041627641 @default.
• W2104130003 hasAuthorship W2104130003A5062859124 @default.
• W2104130003 hasAuthorship W2104130003A5065462815 @default.
• W2104130003 hasAuthorship W2104130003A5081020577 @default.
• W2104130003 hasAuthorship W2104130003A5085166008 @default.
• W2104130003 hasBestOaLocation W21041300031 @default.
• W2104130003 hasConcept C104317684 @default.
• W2104130003 hasConcept C121608353 @default.
• W2104130003 hasConcept C124942203 @default.
• W2104130003 hasConcept C141231307 @default.
• W2104130003 hasConcept C142724271 @default.
• W2104130003 hasConcept C203014093 @default.
• W2104130003 hasConcept C2777658100 @default.
• W2104130003 hasConcept C2779013556 @default.
• W2104130003 hasConcept C502942594 @default.
• W2104130003 hasConcept C54355233 @default.
• W2104130003 hasConcept C61238886 @default.
• W2104130003 hasConcept C71924100 @default.
• W2104130003 hasConcept C86803240 @default.
• W2104130003 hasConceptScore W2104130003C104317684 @default.
• W2104130003 hasConceptScore W2104130003C121608353 @default.
• W2104130003 hasConceptScore W2104130003C124942203 @default.
• W2104130003 hasConceptScore W2104130003C141231307 @default.
• W2104130003 hasConceptScore W2104130003C142724271 @default.
• W2104130003 hasConceptScore W2104130003C203014093 @default.
• W2104130003 hasConceptScore W2104130003C2777658100 @default.
• W2104130003 hasConceptScore W2104130003C2779013556 @default.
• W2104130003 hasConceptScore W2104130003C502942594 @default.
• W2104130003 hasConceptScore W2104130003C54355233 @default.
• W2104130003 hasConceptScore W2104130003C61238886 @default.
• W2104130003 hasConceptScore W2104130003C71924100 @default.
• W2104130003 hasConceptScore W2104130003C86803240 @default.
• W2104130003 hasIssue "2" @default.
• W2104130003 hasLocation W21041300031 @default.
• W2104130003 hasLocation W21041300032 @default.
• W2104130003 hasOpenAccess W2104130003 @default.
• W2104130003 hasPrimaryLocation W21041300031 @default.
• W2104130003 hasRelatedWork W1509879109 @default.
• W2104130003 hasRelatedWork W2052678194 @default.
• W2104130003 hasRelatedWork W2331606468 @default.
• W2104130003 hasRelatedWork W2393830862 @default.
• W2104130003 hasRelatedWork W2413189820 @default.
• W2104130003 hasRelatedWork W2623003466 @default.
• W2104130003 hasRelatedWork W2747570594 @default.
• W2104130003 hasRelatedWork W2947099994 @default.

• next