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- W2104140143 abstract "Retapamulin is a semisynthetic pleuromutilin compound with in vitroactivity against Gram-positive bacteria, no cross-resistance to other classes of antimicrobial agents in current use and a low potential for development of resistance. A 1% ointment formulation has been developed for clinical use, and a placebo-controlled trial of impetigo in 210 patients produced significantly higher rates of clinical and microbiological success compared with placebo – 85.6 versus 52.1% and 91.2 versus 50.9%, respectively. Additional comparative studies in over 1900 patients showed noninferiority to topical fusidic acid and oral cephalexin and a low frequency of adverse events. In 2007, retapamulin was approved in the USA for topical treatment of impetigo caused by Streptococcus pyogenes and methicillin-susceptible Staphylococcus aureus, and in the EU for topical treatment of impetigo and infected wounds caused by S. pyogenes and S. aureus, with approvals including adults and children over 9 months of age." @default.
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- W2104140143 date "2007-12-01" @default.
- W2104140143 modified "2023-10-16" @default.
- W2104140143 title "Retapamulin: a semisynthetic pleuromutilin compound for topical treatment of skin infections in adults and children" @default.
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- W2104140143 doi "https://doi.org/10.2217/17460913.2.6.591" @default.
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