FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2104142489> ?p ?o ?g. }

• W2104142489 abstract "Cortical GABAergic interneurons (INs) are generated in the medial ganglionic eminence (MGE) and migrate tangentially into cortex. Because most, if not all, migrating MGE-derived INs express the neuregulin (NRG) receptor, ErbB4, we investigated influences of Nrg1 isoforms and Nrg3 on IN migration through ventral telencephalon (vTel) and within cortex.During IN migration, NRG expression domains and distributions of ErbB4-expressing, MGE-derived INs are complementary with minimal overlap, both in vTel and cortex. In wild-type mice, within fields of NRG expression, these INs are focused at positions of low or absent NRG expression. However, in ErbB4-/- HER4(heart) mutant mice in which INs lack ErbB4, these complementary patterns are degraded with considerable overlap evident between IN distribution and NRG expression domains. These findings suggest that NRGs are repellents for migrating ErbB4-expressing INs, a function supported by in vitro and in vivo experiments. First, in collagen co-cultures, MGE-derived cells preferentially migrate away from a source of secreted NRGs. Second, cells migrating from wild-type MGE explants on living forebrain slices from wild-type embryonic mice tend to avoid endogenous NRG expression domains, whereas this avoidance behavior is not exhibited by ErbB4-deficient cells migrating from MGE explants and instead they have a radial pattern with a more uniform distribution. Third, ectopic NRG expression in the IN migration pathway produced by in utero electroporation blocks IN migration and results in cortex distal to the blockade being largely devoid of INs. Finally, fewer INs reach cortex in ErbB4 mutants, indicating that NRG-ErbB4 signaling is required for directing IN migration from the MGE to cortex.Our results show that NRGs act as repellents for migrating ErbB4-expressing, MGE-derived GABAergic INs and that the patterned expression of NRGs funnels INs as they migrate from the MGE to their cortical destinations." @default.
• W2104142489 created "2016-06-24" @default.
• W2104142489 creator A5012926933 @default.
• W2104142489 creator A5019560977 @default.
• W2104142489 creator A5023265754 @default.
• W2104142489 creator A5038529172 @default.
• W2104142489 creator A5076039054 @default.
• W2104142489 date "2012-02-29" @default.
• W2104142489 modified "2023-10-15" @default.
• W2104142489 title "Neuregulin repellent signaling via ErbB4 restricts GABAergic interneurons to migratory paths from ganglionic eminence to cortical destinations" @default.
• W2104142489 cites W1589107271 @default.
• W2104142489 cites W1589246521 @default.
• W2104142489 cites W1591788205 @default.
• W2104142489 cites W1715204582 @default.
• W2104142489 cites W1967445973 @default.
• W2104142489 cites W1971305731 @default.
• W2104142489 cites W1973188134 @default.
• W2104142489 cites W1976616514 @default.
• W2104142489 cites W1977725794 @default.
• W2104142489 cites W1978596328 @default.
• W2104142489 cites W1981379485 @default.
• W2104142489 cites W1993895538 @default.
• W2104142489 cites W1994124220 @default.
• W2104142489 cites W2011326452 @default.
• W2104142489 cites W2016016539 @default.
• W2104142489 cites W2016717347 @default.
• W2104142489 cites W2020237866 @default.
• W2104142489 cites W2023195093 @default.
• W2104142489 cites W2024993320 @default.
• W2104142489 cites W2025342494 @default.
• W2104142489 cites W2025868352 @default.
• W2104142489 cites W2031755128 @default.
• W2104142489 cites W2034887388 @default.
• W2104142489 cites W2038226174 @default.
• W2104142489 cites W2043345702 @default.
• W2104142489 cites W2046826788 @default.
• W2104142489 cites W2047007360 @default.
• W2104142489 cites W2061288254 @default.
• W2104142489 cites W2064313800 @default.
• W2104142489 cites W2066635264 @default.
• W2104142489 cites W2074262563 @default.
• W2104142489 cites W2074945963 @default.
• W2104142489 cites W2075460226 @default.
• W2104142489 cites W2076203336 @default.
• W2104142489 cites W2084114120 @default.
• W2104142489 cites W2103828363 @default.
• W2104142489 cites W2112148529 @default.
• W2104142489 cites W2117860217 @default.
• W2104142489 cites W2131192891 @default.
• W2104142489 cites W2134711325 @default.
• W2104142489 cites W2142269585 @default.
• W2104142489 cites W2150533427 @default.
• W2104142489 cites W2159617943 @default.
• W2104142489 cites W2161641617 @default.
• W2104142489 cites W2161820433 @default.
• W2104142489 cites W2172188544 @default.
• W2104142489 cites W4234358442 @default.
• W2104142489 cites W4295274060 @default.
• W2104142489 doi "https://doi.org/10.1186/1749-8104-7-10" @default.
• W2104142489 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/3353847" @default.
• W2104142489 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/22376909" @default.
• W2104142489 hasPublicationYear "2012" @default.
• W2104142489 type Work @default.
• W2104142489 sameAs 2104142489 @default.
• W2104142489 citedByCount "53" @default.
• W2104142489 countsByYear W21041424892012 @default.
• W2104142489 countsByYear W21041424892013 @default.
• W2104142489 countsByYear W21041424892014 @default.
• W2104142489 countsByYear W21041424892015 @default.
• W2104142489 countsByYear W21041424892016 @default.
• W2104142489 countsByYear W21041424892017 @default.
• W2104142489 countsByYear W21041424892018 @default.
• W2104142489 countsByYear W21041424892019 @default.
• W2104142489 countsByYear W21041424892020 @default.
• W2104142489 countsByYear W21041424892021 @default.
• W2104142489 countsByYear W21041424892022 @default.
• W2104142489 crossrefType "journal-article" @default.
• W2104142489 hasAuthorship W2104142489A5012926933 @default.
• W2104142489 hasAuthorship W2104142489A5019560977 @default.
• W2104142489 hasAuthorship W2104142489A5023265754 @default.
• W2104142489 hasAuthorship W2104142489A5038529172 @default.
• W2104142489 hasAuthorship W2104142489A5076039054 @default.
• W2104142489 hasBestOaLocation W21041424891 @default.
• W2104142489 hasConcept C101544691 @default.
• W2104142489 hasConcept C169760540 @default.
• W2104142489 hasConcept C17077164 @default.
• W2104142489 hasConcept C185323287 @default.
• W2104142489 hasConcept C2777348757 @default.
• W2104142489 hasConcept C2778560701 @default.
• W2104142489 hasConcept C2779177108 @default.
• W2104142489 hasConcept C2779715522 @default.
• W2104142489 hasConcept C2780597806 @default.
• W2104142489 hasConcept C2780943970 @default.
• W2104142489 hasConcept C529278444 @default.
• W2104142489 hasConcept C54355233 @default.
• W2104142489 hasConcept C62478195 @default.
• W2104142489 hasConcept C81885089 @default.
• W2104142489 hasConcept C86803240 @default.
• W2104142489 hasConcept C95444343 @default.
• W2104142489 hasConcept C97037327 @default.

• next